Publications by authors named "Timothy A Lewis"

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Author Correction: Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.
Nobutaka Kato, Eamon Comer, Tomoyo Sakata-Kato, Arvind Sharma, Manmohan Sharma, Timothy A Lewis

Nature· December 2025

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Sevabertinib, a Reversible HER2 Inhibitor with Activity in Lung Cancer.
Franziska Siegel, Stephan Siegel, Kristýna Kotýnková, Gizem Karsli Uzunbas, Daniel Korr, Timothy A Lewis

Cancer Discov· October 2025

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Discovery of BAY 2666605, a Molecular Glue for PDE3A and SLFN12.
Timothy A Lewis, Manuel Ellermann, Charlotte Kopitz, Martin Lange, Luc de Waal

ACS Med Chem Lett· October 2024

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Velcrin molecular glues induce apoptosis in glioblastomas with high and expression.
Elisa Aquilanti, Silvia Goldoni, Andrew Baker, Kristyna Kotynkova, Sawyer Andersen, Timothy A Lewis

Neurooncol Adv· July 2024

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Molecular Engineering of Stabilized Silicon-Rosindolizine Shortwave Infrared Fluorophores.
William E Meador, Timothy A Lewis, Abdul K Shaik, Kalpani Hirunika Wijesinghe, Boqian Yang

J Org Chem· March 2024

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Switch-on near infrared emission in albumin behind dark fabric: toward application in forensic latent bloodstain detection.
Matthew A Saucier, Nicholas A Kruse, Timothy A Lewis, Nathan I Hammer, Jared H Delcamp

RSC Adv· March 2024

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Systematic identification of biomarker-driven drug combinations to overcome resistance.
Matthew G Rees, Lisa Brenan, Mariana do Carmo, Patrick Duggan, Besnik Bajrami, Timothy A Lewis

Nat Chem Biol· June 2022

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Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
Colin W Garvie, Xiaoyun Wu, Malvina Papanastasiou, Sooncheol Lee, James Fuller, Timothy A Lewis

Nat Commun· July 2021

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Correction: Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12.
Xiaoyun Wu, Gavin R Schnitzler, Galen F Gao, Brett Diamond, Andrew R Baker, Timothy A Lewis

J Biol Chem· November 2020

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Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12.
Xiaoyun Wu, Gavin R Schnitzler, Galen F Gao, Brett Diamond, Andrew R Baker, Timothy A Lewis

J Biol Chem· March 2020

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Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing.
Timothy A Lewis, Luc de Waal, Xiaoyun Wu, Willmen Youngsaye, Antje Wengner

ACS Med Chem Lett· November 2019

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Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription.
Nicholas B Struntz, Andrew Chen, Anja Deutzmann, Robert M Wilson, Eric Stefan, Timothy A Lewis

Cell Chem Biol· May 2019

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Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway.
Mark A Nakasone, Timothy A Lewis, Olivier Walker, Anita Thakur, Wissam Mansour

Structure· December 2017

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Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells.
Cecilia Lopez-Sambrooks, Shiteshu Shrimal, Carol Khodier, Daniel P Flaherty, Natalie Rinis, Timothy A Lewis

Nat Chem Biol· December 2016

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Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia.
Timothy A Lewis, David B Sykes, Jason M Law, Benito Muñoz, Joane K Rustiguel

ACS Med Chem Lett· December 2016

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Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.
Nobutaka Kato, Eamon Comer, Tomoyo Sakata-Kato, Arvind Sharma, Manmohan Sharma, Timothy A Lewis

Nature· October 2016

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Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.
David B Sykes, Youmna S Kfoury, François E Mercier, Mathias J Wawer, Jason M Law, Timothy A Lewis

Cell· September 2016

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Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile.
Zarko V Boskovic, Melissa M Kemp, Allyson M Freedy, Vasanthi S Viswanathan, Marius S Pop, Timothy A Lewis

ACS Chem Biol· July 2016

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Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.
Luc de Waal, Timothy A Lewis, Matthew G Rees, Aviad Tsherniak, Xiaoyun Wu

Nat Chem Biol· February 2016

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Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation.
Zhengjian Zhang, Zarko Boskovic, Mahmud M Hussain, Wenxin Hu, Carla Inouye, Timothy A Lewis

Elife· August 2015

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Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport.
Chris Dockendorff, Patrick W Faloon, Miao Yu, Willmen Youngsaye, Marsha Penman, Timothy A Lewis

ACS Med Chem Lett· April 2015

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Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2).
Hilaire Playa, Timothy A Lewis, Amal Ting, Byung-Chul Suh, Benito Muñoz

Bioorg Med Chem Lett· December 2014

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