Publications by authors named "Timothy A Stammers"

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Molecular dynamics simulations and structure-based rational design lead to allosteric HCV NS5B polymerase thumb pocket 2 inhibitor with picomolar cellular replicon potency.
Oliver Hucke, René Coulombe, Pierre Bonneau, Mégan Bertrand-Laperle, Christian Brochu, Timothy A Stammers

J Med Chem· March 2014

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Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay.
Timothy A Stammers, René Coulombe, Martin Duplessis, Gulrez Fazal, Alexandre Gagnon

Bioorg Med Chem Lett· December 2013

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Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: discovery of a quinazolinone chemotype.
Pierre L Beaulieu, René Coulombe, Jianmin Duan, Gulrez Fazal, Cédrickx Godbout, Timothy A Stammers

Bioorg Med Chem Lett· July 2013

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Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors.
Timothy A Stammers, René Coulombe, Jean Rancourt, Bounkham Thavonekham, Gulrez Fazal

Bioorg Med Chem Lett· May 2013

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Indole 5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase with nanomolar potency in cell-based subgenomic replicons (part 2): central amino acid linker and right-hand-side SAR studies.
Pierre L Beaulieu, Catherine Chabot, Jianmin Duan, Michel Garneau, James Gillard, Timothy A Stammers

Bioorg Med Chem Lett· June 2011

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