Publications by authors named "Christian Brochu"

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Discovery of BI 207524, an indole diamide NS5B thumb pocket 1 inhibitor with improved potency for the potential treatment of chronic hepatitis C virus infection.
Pierre L Beaulieu, Paul C Anderson, Richard Bethell, Michael Bös, Yves Bousquet, Christian Brochu

J Med Chem· December 2014

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Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.
Lee D Fader, Eric Malenfant, Mathieu Parisien, Rebekah Carson, François Bilodeau, Christian Brochu

ACS Med Chem Lett· April 2014

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Molecular dynamics simulations and structure-based rational design lead to allosteric HCV NS5B polymerase thumb pocket 2 inhibitor with picomolar cellular replicon potency.
Oliver Hucke, René Coulombe, Pierre Bonneau, Mégan Bertrand-Laperle, Christian Brochu

J Med Chem· March 2014

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Conformation-based restrictions and scaffold replacements in the design of hepatitis C virus polymerase inhibitors: discovery of deleobuvir (BI 207127).
Steven R LaPlante, Michael Bös, Christian Brochu, Catherine Chabot, René Coulombe

J Med Chem· March 2014

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NF-κB-dependent role for cold-inducible RNA binding protein in regulating interleukin 1β.
Christian Brochu, Miguel A Cabrita, Brian D Melanson, Jeffrey D Hamill, Rosanna Lau

PLoS One· August 2013

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Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus.
Anne Décor, Chantal Grand-Maître, Oliver Hucke, Jeff O'Meara, Cyrille Kuhn, Christian Brochu

Bioorg Med Chem Lett· July 2013

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A novel cis-acting element from the 3'UTR of DNA damage-binding protein 2 mRNA links transcriptional and post-transcriptional regulation of gene expression.
Brian D Melanson, Miguel A Cabrita, Reetesh Bose, Jeffrey D Hamill, Elysia Pan, Christian Brochu

Nucleic Acids Res· June 2013

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Importance of ligand bioactive conformation in the discovery of potent indole-diamide inhibitors of the hepatitis C virus NS5B.
Steven R LaPlante, James R Gillard, Araz Jakalian, Norman Aubry, René Coulombe, Christian Brochu

J Am Chem Soc· November 2010

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N-Acetamideindolecarboxylic acid allosteric 'finger-loop' inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies.
Pierre L Beaulieu, Eric Jolicoeur, James Gillard, Christian Brochu, René Coulombe

Bioorg Med Chem Lett· February 2010

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Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffolds.
Pierre L Beaulieu, James Gillard, Darren Bykowski, Christian Brochu, Nathalie Dansereau

Bioorg Med Chem Lett· October 2006

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The heat shock protein HSP70 and heat shock cognate protein HSC70 contribute to antimony tolerance in the protozoan parasite leishmania.
Christian Brochu, Anass Haimeur, Marc Ouellette

Cell Stress Chaperones· April 2005

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Potent inhibitors of the hepatitis C virus NS3 protease: design and synthesis of macrocyclic substrate-based beta-strand mimics.
Nathalie Goudreau, Christian Brochu, Dale R Cameron, Jean-Simon Duceppe, Anne-Marie Faucher

J Org Chem· September 2004

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Synthesis of BILN 2061, an HCV NS3 protease inhibitor with proven antiviral effect in humans.
Anne-Marie Faucher, Murray D Bailey, Pierre L Beaulieu, Christian Brochu, Jean-Simon Duceppe

Org Lett· August 2004

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Structure-activity study on a novel series of macrocyclic inhibitors of the hepatitis C virus NS3 protease leading to the discovery of BILN 2061.
Montse Llinàs-Brunet, Murray D Bailey, Gordon Bolger, Christian Brochu, Anne-Marie Faucher

J Med Chem· March 2004

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Discovery of small-molecule inhibitors of the ATPase activity of human papillomavirus E1 helicase.
Anne-Marie Faucher, Peter W White, Christian Brochu, Chantal Grand-Maître, Jean Rancourt

J Med Chem· January 2004

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Antimony uptake systems in the protozoan parasite Leishmania and accumulation differences in antimony-resistant parasites.
Christian Brochu, Jingyu Wang, Gaétan Roy, Nadine Messier, Xiao-Yan Wang

Antimicrob Agents Chemother· October 2003

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Modulation of gene expression in Leishmania drug resistant mutants as determined by targeted DNA microarrays.
Chantal Guimond, Nathalie Trudel, Christian Brochu, Nathalie Marquis, Amal El Fadili

Nucleic Acids Res· October 2003

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Thiol-induced reduction of antimony(V) into antimony(III): a comparative study with trypanothione, cysteinyl-glycine, cysteine and glutathione.
Claúdio dos Santos Ferreira, Patricia Silveira Martins, Cynthia Demicheli, Christian Brochu, Marc Ouellette

Biometals· September 2003

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