Publications by authors named "Timothy A Vickers"

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Insights into innate immune activation via PS-ASO-protein-TLR9 interactions.
Adam J Pollak, Luyi Zhao, Timothy A Vickers, Ian J Huggins, Xue-Hai Liang

Nucleic Acids Res· August 2022

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NAT10 and DDX21 Proteins Interact with RNase H1 and Affect the Performance of Phosphorothioate Oligonucleotides.
Lingdi Zhang, Karla D Bernardo, Timothy A Vickers, Jun Tian, Xue-Hai Liang

Nucleic Acid Ther· August 2022

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Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.
Brooke A Anderson, Graeme C Freestone, Audrey Low, Cheryl L De-Hoyos, William J Drury Iii, Timothy A Vickers

Nucleic Acids Res· September 2021

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Binding of phosphorothioate oligonucleotides with RNase H1 can cause conformational changes in the protein and alter the interactions of RNase H1 with other proteins.
Lingdi Zhang, Timothy A Vickers, Hong Sun, Xue-Hai Liang, Stanley T Crooke

Nucleic Acids Res· March 2021

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The Interaction of Phosphorothioate-Containing RNA Targeted Drugs with Proteins Is a Critical Determinant of the Therapeutic Effects of These Agents.
Stanley T Crooke, Punit P Seth, Timothy A Vickers, Xue-Hai Liang

J Am Chem Soc· September 2020

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Phosphorothioate modified oligonucleotide-protein interactions.
Stanley T Crooke, Timothy A Vickers, Xue-Hai Liang

Nucleic Acids Res· June 2020

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Interaction of ASOs with PC4 Is Highly Influenced by the Cellular Environment and ASO Chemistry.
Timothy A Vickers, Michael T Migawa, Punit P Seth, Stanley T Crooke

J Am Chem Soc· May 2020

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Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins.
Malwina Hyjek-Składanowska, Timothy A Vickers, Agnieszka Napiórkowska, Brooke A Anderson, Michael Tanowitz

J Am Chem Soc· April 2020

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Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes.
Xue-Hai Liang, Hong Sun, Chih-Wei Hsu, Joshua G Nichols, Timothy A Vickers

Nucleic Acids Res· February 2020

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Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1.
Timothy A Vickers, Meghdad Rahdar, Thazha P Prakash, Stanley T Crooke

Nucleic Acids Res· November 2019

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mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway.
Xue-Hai Liang, Joshua G Nichols, Chih-Wei Hsu, Timothy A Vickers, Stanley T Crooke

Nucleic Acids Res· July 2019

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Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index.
Wen Shen, Cheryl L De Hoyos, Michael T Migawa, Timothy A Vickers, Hong Sun

Nat Biotechnol· June 2019

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COPII vesicles can affect the activity of antisense oligonucleotides by facilitating the release of oligonucleotides from endocytic pathways.
Xue-Hai Liang, Hong Sun, Joshua G Nichols, Nickolas Allen, Shiyu Wang, Timothy A Vickers

Nucleic Acids Res· November 2018

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Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides.
Shiyu Wang, Nickolas Allen, Timothy A Vickers, Alexey S Revenko, Hong Sun

Nucleic Acids Res· April 2018

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Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins.
Wen Shen, Cheryl L De Hoyos, Hong Sun, Timothy A Vickers, Xue-Hai Liang

Nucleic Acids Res· March 2018

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Development of a Quantitative BRET Affinity Assay for Nucleic Acid-Protein Interactions.
Timothy A Vickers, Stanley T Crooke

PLoS One· August 2017

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Cellular uptake and trafficking of antisense oligonucleotides.
Stanley T Crooke, Shiyu Wang, Timothy A Vickers, Wen Shen, Xue-Hai Liang

Nat Biotechnol· March 2017

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Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames.
Xue-Hai Liang, Wen Shen, Hong Sun, Michael T Migawa, Timothy A Vickers

Nat Biotechnol· August 2016

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Modulation of LMNA splicing as a strategy to treat prelamin A diseases.
John M Lee, Chika Nobumori, Yiping Tu, Catherine Choi, Shao H Yang, Timothy A Vickers

J Clin Invest· April 2016

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Targeting of repeated sequences unique to a gene results in significant increases in antisense oligonucleotide potency.
Timothy A Vickers, Susan M Freier, Huynh-Hoa Bui, Andrew Watt, Stanley T Crooke

PLoS One· December 2015

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Defining the factors that contribute to on-target specificity of antisense oligonucleotides.
Walt F Lima, Timothy A Vickers, Josh Nichols, Cheryl Li, Stanley T Crooke

PLoS One· November 2015

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The rates of the major steps in the molecular mechanism of RNase H1-dependent antisense oligonucleotide induced degradation of RNA.
Timothy A Vickers, Stanley T Crooke

Nucleic Acids Res· October 2015

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Antisense oligonucleotides capable of promoting specific target mRNA reduction via competing RNase H1-dependent and independent mechanisms.
Timothy A Vickers, Stanley T Crooke

PLoS One· June 2015

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siRNAs targeted to certain polyadenylation sites promote specific, RISC-independent degradation of messenger RNAs.
Timothy A Vickers, Stanley T Crooke

Nucleic Acids Res· July 2012

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U1 adaptors result in reduction of multiple pre-mRNA species principally by sequestering U1snRNP.
Timothy A Vickers, Mahyar Sabripour, Stanley T Crooke

Nucleic Acids Res· May 2011

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