Publications by authors named "Michael Tanowitz"

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Single alkyl phosphonate modification of the siRNA backbone in the seed region enhances specificity and therapeutic profile.
Mehran Nikan, Qingfeng Li, Michael Tanowitz, Hongda Li, Sagar Damle

Nucleic Acids Res· July 2025

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Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles.
Michael E Østergaard, Michele Carrer, Brooke A Anderson, Megan Afetian, Mohsen A Bakooshli, Michael Tanowitz

Nucleic Acids Res· April 2025

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Targeted Delivery of Antisense Oligonucleotides Through Angiotensin Type 1 Receptor.
Carol Kuo, Mehran Nikan, Steve T Yeh, Alfred E Chappell, Michael Tanowitz

Nucleic Acid Ther· August 2022

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Evaluation of Phosphorus and Non-Phosphorus Neutral Oligonucleotide Backbones for Enhancing Therapeutic Index of Gapmer Antisense Oligonucleotides.
Guillermo Vasquez, Michael T Migawa, W Brad Wan, Audrey Low, Michael Tanowitz

Nucleic Acid Ther· February 2022

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Overcoming the challenges of tissue delivery for oligonucleotide therapeutics.
Tufan Gökirmak, Mehran Nikan, Svenja Wiechmann, Thazha P Prakash, Michael Tanowitz

Trends Pharmacol Sci· July 2021

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High-resolution visualization and quantification of nucleic acid-based therapeutics in cells and tissues using Nanoscale secondary ion mass spectrometry (NanoSIMS).
Cuiwen He, Michael T Migawa, Kai Chen, Thomas A Weston, Michael Tanowitz

Nucleic Acids Res· January 2021

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Targeted Delivery of Antisense Oligonucleotides Using Neurotensin Peptides.
Mehran Nikan, Michael Tanowitz, Chrissa A Dwyer, Michaela Jackson, Hans J Gaus

J Med Chem· August 2020

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Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins.
Malwina Hyjek-Składanowska, Timothy A Vickers, Agnieszka Napiórkowska, Brooke A Anderson, Michael Tanowitz

J Am Chem Soc· April 2020

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Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates.
Michael E Østergaard, Michaela Jackson, Audrey Low, Alfred E Chappell, Richard G Lee, Michael Tanowitz

Nucleic Acids Res· July 2019

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Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins.
Michael T Migawa, Wen Shen, W Brad Wan, Guillermo Vasquez, Michael E Oestergaard, Michael Tanowitz

Nucleic Acids Res· June 2019

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Selective tissue targeting of synthetic nucleic acid drugs.
Punit P Seth, Michael Tanowitz, C Frank Bennett

J Clin Invest· March 2019

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Receptor-Mediated Uptake of Phosphorothioate Antisense Oligonucleotides in Different Cell Types of the Liver.
Colton M Miller, Michael Tanowitz, Aaron J Donner, Thazha P Prakash, Eric E Swayze

Nucleic Acid Ther· June 2018

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Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes.
Michael Tanowitz, Lisa Hettrick, Alexey Revenko, Garth A Kinberger, Thazha P Prakash

Nucleic Acids Res· December 2017

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Intra-endosomal trafficking mediated by lysobisphosphatidic acid contributes to intracellular release of phosphorothioate-modified antisense oligonucleotides.
Shiyu Wang, Hong Sun, Michael Tanowitz, Xue-Hai Liang, Stanley T Crooke

Nucleic Acids Res· May 2017

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Annexin A2 facilitates endocytic trafficking of antisense oligonucleotides.
Shiyu Wang, Hong Sun, Michael Tanowitz, Xue-Hai Liang, Stanley T Crooke

Nucleic Acids Res· September 2016

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Synthesis and biological evaluation of sialyl-oligonucleotide conjugates targeting leukocyte B trans-membranal receptor CD22 as delivery agents for nucleic acid drugs.
Gabrielle St-Pierre, Sudip Pal, Michael E Østergaard, Tianyuan Zhou, Jinghua Yu, Michael Tanowitz

Bioorg Med Chem· June 2016

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Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
Keith R Hornberger, Dan M Berger, Andrew P Crew, Hanqing Dong, Andrew Kleinberg, Michael Tanowitz

Bioorg Med Chem Lett· August 2013

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Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder.
Holly A Garriock, Michael Tanowitz, Jeffrey B Kraft, Vu C Dang, Eric J Peters

Am J Psychiatry· May 2010

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Alternative splicing determines the post-endocytic sorting fate of G-protein-coupled receptors.
Michael Tanowitz, James N Hislop, Mark von Zastrow

J Biol Chem· December 2008

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A novel endocytic recycling signal distinguishes biological responses of Trk neurotrophin receptors.
Zhe-Yu Chen, Alessandro Ieraci, Michael Tanowitz, Francis S Lee

Mol Biol Cell· December 2005

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Identification of protein interactions by yeast two-hybrid screening and coimmunoprecipitation.
Michael Tanowitz, Mark von Zastrow

Methods Mol Biol· August 2004

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A novel endocytic recycling signal that distinguishes the membrane trafficking of naturally occurring opioid receptors.
Michael Tanowitz, Mark von Zastrow

J Biol Chem· November 2003

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Ubiquitination-independent trafficking of G protein-coupled receptors to lysosomes.
Michael Tanowitz, Mark Von Zastrow

J Biol Chem· December 2002

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