Publications by authors named "Mehran Nikan"

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Discovery of long-acting APOC3 siRNA for treating patients with hypertriglyceridemia.
Thazha P Prakash, Adam E Mullick, Stan Riney, Jinghua Yu, Mehran Nikan

Nucleic Acids Res· October 2025

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Single alkyl phosphonate modification of the siRNA backbone in the seed region enhances specificity and therapeutic profile.
Mehran Nikan, Qingfeng Li, Michael Tanowitz, Hongda Li, Sagar Damle

Nucleic Acids Res· July 2025

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High-resolution visualisation of antisense oligonucleotide release from polymers in cells.
Jessica J King, Kai Chen, Cameron W Evans, Marck Norret, Ruba Almasri, Mehran Nikan

Chem Sci· August 2024

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Tool to Resolve Distortions in Elemental and Isotopic Imaging.
Chixiang Lu, Gu Chen, Wenxin Song, Kai Chen, Charmaine Hee, Mehran Nikan

J Am Chem Soc· July 2024

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Inhibition of ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs and enhances object location memory.
Claire C Chen, Joseph Han, Carlene A Chinn, Jacob S Rounds, Xiang Li, Mehran Nikan

Elife· February 2024

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Inhibition of CPEB3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memory.
Claire C Chen, Joseph Han, Carlene A Chinn, Jacob S Rounds, Xiang Li, Mehran Nikan

bioRxiv· June 2023

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Targeted Delivery of Antisense Oligonucleotides Through Angiotensin Type 1 Receptor.
Carol Kuo, Mehran Nikan, Steve T Yeh, Alfred E Chappell, Michael Tanowitz

Nucleic Acid Ther· August 2022

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Overcoming the challenges of tissue delivery for oligonucleotide therapeutics.
Tufan Gökirmak, Mehran Nikan, Svenja Wiechmann, Thazha P Prakash, Michael Tanowitz

Trends Pharmacol Sci· July 2021

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Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell.
Laurent Knerr, Thazha P Prakash, Richard Lee, William J Drury Iii, Mehran Nikan

J Am Chem Soc· March 2021

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Targeted Delivery of Antisense Oligonucleotides Using Neurotensin Peptides.
Mehran Nikan, Michael Tanowitz, Chrissa A Dwyer, Michaela Jackson, Hans J Gaus

J Med Chem· August 2020

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Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.
Maire F Osborn, Andrew H Coles, Annabelle Biscans, Reka A Haraszti, Loic Roux, Mehran Nikan

Nucleic Acids Res· February 2019

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-Acyl-2-Thioethyl: A Convenient Base-Labile Protecting Group for the Synthesis of siRNAs Containing 5'-Vinylphosphonate.
Mehran Nikan, Wenyu Li, Garth A Kinberger, Punit P Seth, Eric E Swayze

Molecules· January 2019

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Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier.
Bruno M D C Godinho, Nils Henninger, James Bouley, Julia F Alterman, Reka A Haraszti, Mehran Nikan

Mol Ther· November 2018

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Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles.
Annabelle Biscans, Reka A Haraszti, Dimas Echeverria, Rachael Miller, Marie-Cecile Didiot, Mehran Nikan

Mol Ther· June 2018

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Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo.
Matthew R Hassler, Anton A Turanov, Julia F Alterman, Reka A Haraszti, Andrew H Coles, Mehran Nikan

Nucleic Acids Res· March 2018

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Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay.
Bruno M D C Godinho, James W Gilbert, Reka A Haraszti, Andrew H Coles, Annabelle Biscans, Mehran Nikan

Nucleic Acid Ther· December 2017

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Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain.
Mehran Nikan, Maire F Osborn, Andrew H Coles, Annabelle Biscans, Bruno M D C Godinho

Bioconjug Chem· June 2017

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Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain.
Mehran Nikan, Maire F Osborn, Andrew H Coles, Bruno Mdc Godinho, Lauren M Hall

Mol Ther Nucleic Acids· August 2016

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Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs.
Maire F Osborn, Julia F Alterman, Mehran Nikan, Hong Cao, Marie C Didiot

Nucleic Acids Res· October 2015

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An acetylene-bridged 6,8-purine dimer as a fluorescent switch-on probe for parallel G-quadruplexes.
Mehran Nikan, Marco Di Antonio, Keren Abecassis, Keith McLuckie, Shankar Balasubramanian

Angew Chem Int Ed Engl· January 2013

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Crystal structure of a template-assembled synthetic G-quadruplex.
Mehran Nikan, Brian O Patrick, John C Sherman

Chembiochem· July 2012

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A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro.
Eun-Ang Raiber, Ramon Kranaster, Enid Lam, Mehran Nikan, Shankar Balasubramanian

Nucleic Acids Res· February 2012

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Small-molecule-induced DNA damage identifies alternative DNA structures in human genes.
Raphaël Rodriguez, Kyle M Miller, Josep V Forment, Charles R Bradshaw, Mehran Nikan

Nat Chem Biol· February 2012

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Cation-complexation behavior of template-assembled synthetic G-quartets.
Mehran Nikan, John C Sherman

J Org Chem· August 2009

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Template-assembled synthetic G-quartets (TASQs).
Mehran Nikan, John C Sherman

Angew Chem Int Ed Engl· August 2008

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