Publications by authors named "Timothy A Whitehead"

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Unusually broad-spectrum small-molecule sensing using a single protein scaffold.
Hao Tian, Jesús Beltrán, Wesley George, Chase Lenert-Mondou, Norman Seder, Timothy A Whitehead

Proc Natl Acad Sci U S A· December 2025

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Computational redesign of a thermostable T7 RNA polymerase.
Zachary T Baumer, Timothy A Whitehead

bioRxiv· November 2025

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PYR1 Biosensor-Driven Genome-Wide CRISPR Screens for Improved Monoterpene Production in .
Nicholas R Robertson, Chase Lenert-Mondou, Alison C Leonard, Aida Tafrishi, Stephanie Carrera, Timothy A Whitehead

ACS Synth Biol· August 2025

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Computational design of dynamic biosensors for emerging synthetic opioids.
Alison C Leonard, Chase Lenert-Mondou, Rachel Chayer, Samuel Swift, Zachary T Baumer, Timothy A Whitehead

bioRxiv· May 2025

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Retrospective SARS-CoV-2 human antibody development trajectories are largely sparse and permissive.
Monica B Kirby, Brian M Petersen, Jonathan G Faris, Siobhan P Kells, Kayla G Sprenger, Timothy A Whitehead

Proc Natl Acad Sci U S A· January 2025

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Engineered Stop and Go T7 RNA Polymerases.
Zachary T Baumer, Matilda S Newton, Lina Löfstrand, Genesis Nicole Carpio Paucar, Natalie G Farny, Timothy A Whitehead

ACS Synth Biol· December 2024

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Rationalizing Diverse Binding Mechanisms to the Same Protein Fold: Insights for Ligand Recognition and Biosensor Design.
Alison C Leonard, Anika J Friedman, Rachel Chayer, Brian M Petersen, Janty Woojuh, Timothy A Whitehead

ACS Chem Biol· August 2024

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GMMA Can Stabilize Proteins Across Different Functional Constraints.
Nicolas Daffern, Kristoffer E Johansson, Zachary T Baumer, Nicholas R Robertson, Janty Woojuh, Timothy A Whitehead

J Mol Biol· June 2024

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An integrated technology for quantitative wide mutational scanning of human antibody Fab libraries.
Brian M Petersen, Monica B Kirby, Karson M Chrispens, Olivia M Irvin, Isabell K Strawn, Timothy A Whitehead

Nat Commun· May 2024

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Deep screening of antibody-antigen affinities.
Timothy A Whitehead

Nat Biomed Eng· March 2024

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Enhanced T cell receptor specificity through framework engineering.
Aaron M Rosenberg, Cory M Ayres, Angélica V Medina-Cucurella, Timothy A Whitehead, Brian M Baker

Front Immunol· March 2024

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Rationalizing diverse binding mechanisms to the same protein fold: insights for ligand recognition and biosensor design.
Alison C Leonard, Anika J Friedman, Rachel Chayer, Brian M Petersen, Joel Kaar, Timothy A Whitehead

bioRxiv· March 2024

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Standardizing cassette-based deep mutagenesis by Golden Gate assembly.
Nicolas Daffern, Irene M Francino-Urdaniz, Zachary T Baumer, Timothy A Whitehead

Biotechnol Bioeng· January 2024

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An orthogonalized PYR1-based CID module with reprogrammable ligand-binding specificity.
Sang-Youl Park, Jingde Qiu, Shuang Wei, Francis C Peterson, Jesús Beltrán, Timothy A Whitehead

Nat Chem Biol· January 2024

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An integrated technology for quantitative wide mutational scanning of human antibody Fab libraries.
Brian M Petersen, Monica B Kirby, Karson M Chrispens, Olivia M Irvin, Isabell K Strawn, Timothy A Whitehead

bioRxiv· January 2024

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A method for generating user-defined circular single-stranded DNA from plasmid DNA using Golden Gate intramolecular ligation.
Isabell K Strawn, Paul J Steiner, Matilda S Newton, Zachary T Baumer, Timothy A Whitehead

Biotechnol Bioeng· October 2023

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High-Performance Cannabinoid Sensor Empowered by Plant Hormone Receptors and Antifouling Magnetic Nanorods.
Zongbo Li, Yuyang Shen, Jesús Beltrán, Hao Tian, Matthew Bedewitz, Timothy A Whitehead

ACS Sens· October 2023

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A Closed Form Model for Molecular Ratchet-Type Chemically Induced Dimerization Modules.
Paul J Steiner, Samuel D Swift, Matthew Bedewitz, Ian Wheeldon, Sean R Cutler, Timothy A Whitehead

Biochemistry· January 2023

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Rapid biosensor development using plant hormone receptors as reprogrammable scaffolds.
Jesús Beltrán, Paul J Steiner, Matthew Bedewitz, Shuang Wei, Francis C Peterson, Timothy A Whitehead

Nat Biotechnol· December 2022

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Design and engineering of genetically encoded protein biosensors for small molecules.
Alison C Leonard, Timothy A Whitehead

Curr Opin Biotechnol· December 2022

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Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways.
Fangzhu Zhao, Celina Keating, Gabriel Ozorowski, Namir Shaabani, Irene M Francino-Urdaniz, Timothy A Whitehead

iScience· September 2022

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Facile Assembly of Combinatorial Mutagenesis Libraries Using Nicking Mutagenesis.
Monica B Kirby, Timothy A Whitehead

Methods Mol Biol· June 2022

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Stabilization of the SARS-CoV-2 receptor binding domain by protein core redesign and deep mutational scanning.
Alison C Leonard, Jonathan J Weinstein, Paul J Steiner, Annette H Erbse, Sarel J Fleishman, Timothy A Whitehead

Protein Eng Des Sel· February 2022

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An overview of methods for the structural and functional mapping of epitopes recognized by anti-SARS-CoV-2 antibodies.
Irene M Francino-Urdaniz, Timothy A Whitehead

RSC Chem Biol· December 2021

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Stabilization of the SARS-CoV-2 Receptor Binding Domain by Protein Core Redesign and Deep Mutational Scanning.
Alison C Leonard, Jonathan J Weinstein, Paul J Steiner, Annette H Erbse, Sarel J Fleishman, Timothy A Whitehead

bioRxiv· November 2021

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