Publications by authors named "Timothy C Chambers"

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The response of phyllodes tumor of the breast to anticancer therapy: An and study.
Alicja Urbaniak, Fariba Jousheghany, Youzhong Yuan, Sergio Piña-Oviedo, Adam Huczyński, Magdalena Delgado, Thomas Kieber-Emmons, Behjatolah Monzavi-Karbassi, Timothy C Chambers

Oncol Lett· November 2019

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Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models.
Alicja Urbaniak, Billie Heflin, Eric R Siegel, Drew Seale, Megan R Reed, Timothy C Chambers

ACS Pharmacol Transl Sci· November 2025

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Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG.
Meenakshi Upreti, Astgik Petrosyan, Matthew E Thornton, Anahit Hovsepyan, G Esteban Fernandez, Timothy C Chambers

Oncogene· October 2025

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Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model.
Alicja Urbaniak, Billie Heflin, Eric Siegel, Megan R Reed, James S Nix, Timothy C Chambers

bioRxiv· July 2025

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Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer.
Alicja Urbaniak, Megan R Reed, Billie Heflin, John Gaydos, Sergio Piña-Oviedo, Timothy C Chambers

Biomed Pharmacother· September 2022

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Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways.
Magdalena Delgado, Randall R Rainwater, Billie Heflin, Alicja Urbaniak, Kaitlynn Butler, Timothy C Chambers

J Biol Chem· June 2022

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Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models.
Alicja Urbaniak, Megan R Reed, Daniel Fil, Anika Moorjani, Sarah Heflin, Timothy C Chambers

Biomed Pharmacother· September 2021

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Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle.
Magdalena Delgado, Charity L Washam, Alicja Urbaniak, Billie Heflin, Aaron J Storey, Timothy C Chambers

ACS Omega· September 2021

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Synthesis, anticancer activity and molecular docking studies of N-deacetylthiocolchicine and 4-iodo-N-deacetylthiocolchicine derivatives.
Greta Klejborowska, Alicja Urbaniak, Ewa Maj, Joanna Wietrzyk, Mahshad Moshari, Timothy C Chambers

Bioorg Med Chem· February 2021

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Limitations of an ex vivo breast cancer model for studying the mechanism of action of the anticancer drug paclitaxel.
Alicja Urbaniak, Sergio Piña-Oviedo, Youzhong Yuan, Adam Huczyński, Timothy C Chambers

Eur J Pharmacol· January 2021

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Carbamate derivatives of colchicine show potent activity towards primary acute lymphoblastic leukemia and primary breast cancer cells-in vitro and ex vivo study.
Alicja Urbaniak, Fariba Jousheghany, Sergio Piña-Oviedo, Youzhong Yuan, Urszula Majcher-Uchańska, Timothy C Chambers

J Biochem Mol Toxicol· June 2020

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Synthesis, biological evaluation and molecular docking studies of new amides of 4-chlorothiocolchicine as anticancer agents.
Greta Klejborowska, Alicja Urbaniak, Ewa Maj, Jordane Preto, Mahshad Moshari, Timothy C Chambers

Bioorg Chem· April 2020

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Synthesis and Anticancer Activity of Tertiary Amides of Salinomycin and Their C20-oxo Analogues.
Dominika Czerwonka, Alicja Urbaniak, Szymon Sobczak, Sergio Piña-Oviedo, Timothy C Chambers

ChemMedChem· January 2020

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Synthesis, biological evaluation and molecular docking studies of new amides of 4-bromothiocolchicine as anticancer agents.
Greta Klejborowska, Alicja Urbaniak, Jordane Preto, Ewa Maj, Mahshad Moshari, Timothy C Chambers

Bioorg Med Chem· December 2019

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Microtubules play an essential role in the survival of primary acute lymphoblastic leukemia cells advancing through G1 phase.
Magdalena Delgado, Timothy C Chambers

Cell Cycle· November 2019

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Contrasting effects of microtubule destabilizers versus stabilizers on induction of death in G1 phase of the cell cycle.
Magdalena Delgado, Alicja Urbaniak, Timothy C Chambers

Biochem Pharmacol· April 2019

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Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes.
Urszula Majcher, Alicja Urbaniak, Ewa Maj, Mahshad Moshari, Magdalena Delgado, Timothy C Chambers

Bioorg Chem· December 2018

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Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo.
Michał Antoszczak, Alicja Urbaniak, Magdalena Delgado, Ewa Maj, Björn Borgström, Timothy C Chambers

Eur J Med Chem· August 2018

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Salinomycin derivatives exhibit activity against primary acute lymphoblastic leukemia (ALL) cells in vitro.
Alicja Urbaniak, Magdalena Delgado, Michał Antoszczak, Adam Huczyński, Timothy C Chambers

Biomed Pharmacother· March 2018

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Preparation of Primary Acute Lymphoblastic Leukemia Cells in Different Cell Cycle Phases by Centrifugal Elutriation.
Magdalena Delgado, Anisha Kothari, Walter N Hittelman, Timothy C Chambers

J Vis Exp· November 2017

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Small peptide substrates and high resolution peptide gels for the analysis of site-specific protein phosphorylation and dephosphorylation.
Laura Johnson Battle, Timothy C Chambers

J Biol Methods· August 2017

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Activity of resveratrol triesters against primary acute lymphoblastic leukemia cells.
Alicja Urbaniak, Magdalena Delgado, Karol Kacprzak, Timothy C Chambers

Bioorg Med Chem Lett· June 2017

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Intracellular Oxygen Concentration Determined By Mitochondrial Respiration Regulates Production of Reactive Oxygen Species.
Ara Kim Wiese, Sara Prior, Timothy C Chambers, Masahiro Higuchi

Integr Cancer Biol Res· January 2017

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Mitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified.
Rong Chu, Sarah E Alford, Katherine Hart, Anisha Kothari, Samuel G Mackintosh, Timothy C Chambers

Oncotarget· November 2016

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Cell Cycle-Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells.
Anisha Kothari, Walter N Hittelman, Timothy C Chambers

Cancer Res· June 2016

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