Publications by authors named "Timothy Caldwell"

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CO-STIMULATORY BLOCKADE PREVENTS INTRAGRAFT ACCRUAL OF CLASS-SWITCHED, ACTIVATED B CELLS DESPITE FAILING TO PREVENT T-CELL MEDIATED REJECTION.
J Timothy Caldwell, Tiffany Shi, Ashley R Burg, Ashley Koby, Krishna M Roskin

bioRxiv· October 2025

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Barriers to Use of Experimental Analysis in Applied Behavior Analysis Clinical Practice.
Timothy D Caldwell, Kimberly A Schreck, Adriannah N Spisak, Jeremy I Katz

Behav Anal Pract· September 2025

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Single-cell transcriptomic analysis of renal allograft rejection reveals insights into intragraft TCR clonality.
Tiffany Shi, Ashley R Burg, J Timothy Caldwell, Krishna M Roskin, Cyd M Castro-Rojas

J Clin Invest· July 2023

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Relationship between piperacillin concentrations, clinical factors and piperacillin/tazobactam-associated acute kidney injury.
Sonya Tang Girdwood, Denise Hasson, J Timothy Caldwell, Cara Slagle, Shun Dong

J Antimicrob Chemother· February 2023

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Single cell transcriptomic analysis of renal allograft rejection reveals novel insights into intragraft TCR clonality.
Tiffany Shi, Ashley R Burg, J Timothy Caldwell, Krishna Roskin, Cyd M Castro-Rojas

bioRxiv· February 2023

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Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT).
Timothy M Caldwell, Yu Mi Ahn, Stacie L Bulfer, Cynthia B Leary, Molly M Hood

Bioorg Med Chem Lett· October 2022

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Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors.
Timothy M Caldwell, Michael D Kaufman, Scott C Wise, Yu Mi Ahn, Molly M Hood

Bioorg Med Chem Lett· October 2022

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Vimseltinib: A Precision CSF1R Therapy for Tenosynovial Giant Cell Tumors and Diseases Promoted by Macrophages.
Bryan D Smith, Michael D Kaufman, Scott C Wise, Yu Mi Ahn, Timothy M Caldwell

Mol Cancer Ther· November 2021

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Smoke from regional wildfires alters lake ecology.
Facundo Scordo, Sudeep Chandra, Erin Suenaga, Suzanne J Kelson, Joshua Culpepper, Timothy J Caldwell

Sci Rep· May 2021

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Ecosystem response to earlier ice break-up date: Climate-driven changes to water temperature, lake-habitat-specific production, and trout habitat and resource use.
Timothy J Caldwell, Sudeep Chandra, Karly Feher, James B Simmons, Zeb Hogan

Glob Chang Biol· October 2020

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Prospective clinical testing and experimental validation of the Pediatric Sepsis Biomarker Risk Model.
Hector R Wong, J Timothy Caldwell, Natalie Z Cvijanovich, Scott L Weiss, Julie C Fitzgerald

Sci Transl Med· November 2019

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Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants.
Bryan D Smith, Michael D Kaufman, Wei-Ping Lu, Anu Gupta, Cynthia B Leary, Timothy M Caldwell

Cancer Cell· May 2019

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Reducing Electrolyte Testing in Hospitalized Children by Using Quality Improvement Methods.
Michael J Tchou, Sonya Tang Girdwood, Benjamin Wormser, Meifawn Poole, Stephanie Davis-Rodriguez, J Timothy Caldwell

Pediatrics· May 2018

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Gene Signature of High White Blood Cell Count in B-Precursor Acute Lymphoblastic Leukemia.
Holly Edwards, Mara Rubenstein, Alan A Dombkowski, J Timothy Caldwell, Roland Chu

PLoS One· July 2017

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Binding of Released Bim to Mcl-1 is a Mechanism of Intrinsic Resistance to ABT-199 which can be Overcome by Combination with Daunorubicin or Cytarabine in AML Cells.
Xiaojia Niu, Jianyun Zhao, Jun Ma, Chengzhi Xie, Holly Edwards, J Timothy Caldwell

Clin Cancer Res· September 2016

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Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2.
Bryan D Smith, Michael D Kaufman, Cynthia B Leary, Benjamin A Turner, Scott C Wise, Timothy M Caldwell

Mol Cancer Ther· September 2015

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Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.
James R Henry, Michael D Kaufman, Sheng-Bin Peng, Yu Mi Ahn, Timothy M Caldwell

J Med Chem· May 2015

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Obatoclax potentiates the cytotoxic effect of cytarabine on acute myeloid leukemia cells by enhancing DNA damage.
Chengzhi Xie, Holly Edwards, J Timothy Caldwell, Guan Wang, Jeffrey W Taub

Mol Oncol· February 2015

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Synergistic antitumor interactions between MK-1775 and panobinostat in preclinical models of pancreatic cancer.
Guan Wang, Xiaojia Niu, Wenbo Zhang, J Timothy Caldwell, Holly Edwards

Cancer Lett· January 2015

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Prognosis and management of acute myeloid leukemia in patients with Down syndrome.
J Timothy Caldwell, Yubin Ge, Jeffrey W Taub

Expert Rev Hematol· December 2014

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Targeting the wee1 kinase for treatment of pediatric Down syndrome acute myeloid leukemia.
J Timothy Caldwell, Holly Edwards, Steven A Buck, Yubin Ge, Jeffrey W Taub

Pediatr Blood Cancer· October 2014

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Panobinostat enhances cytarabine and daunorubicin sensitivities in AML cells through suppressing the expression of BRCA1, CHK1, and Rad51.
Chengzhi Xie, Christina Drenberg, Holly Edwards, J Timothy Caldwell, Wei Chen

PLoS One· August 2014

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CHK1 plays a critical role in the anti-leukemic activity of the wee1 inhibitor MK-1775 in acute myeloid leukemia cells.
Wenxiu Qi, Chengzhi Xie, Chunhuai Li, J Timothy Caldwell, Holly Edwards

J Hematol Oncol· August 2014

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Panobinostat synergistically enhances the cytotoxic effects of cisplatin, doxorubicin or etoposide on high-risk neuroblastoma cells.
Guan Wang, Holly Edwards, J Timothy Caldwell, Steven A Buck, William Y Qing

PLoS One· June 2014

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Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.
Kevin J Hodgetts, Charles A Blum, Timothy Caldwell, Rajagopal Bakthavatchalam, Xiaozhang Zheng

Bioorg Med Chem Lett· August 2010

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