Publications by authors named "Timothy Egan"

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Heme processing in the malaria parasite, Plasmodium falciparum: a time-dependent basal-level analysis.
Larnelle F Garnie, Timothy J Egan, Kathryn J Wicht

Commun Biol· November 2025

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A Delphi process to define medical reporting outcomes for urgent surgical pathways.
Thomas Botrel, Paul S Myles, Emmanuel Futier, Delphine Garrigue, Max Bell, Timothy Egan

Anaesth Crit Care Pain Med· August 2025

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Handheld ultrasound versus palpation technique for radial artery cannulation in conscious patients before noncardiac surgery: an open-label randomised controlled study.
Timothy C Egan, Tom E F Abbott, Gareth L Ackland,

Br J Anaesth· April 2025

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Heme Detoxification in the Malaria Parasite : A Time-Dependent Basal-Level Analysis.
Larnelle F Garnie, Timothy J Egan, Kathryn J Wicht

bioRxiv· March 2025

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Synthesis and SAR Studies of Acyl-Thiourea Platinum(II) Complexes Yield Analogs with Dual-Stage Antiplasmodium Activity.
Fatima-Zahra Ishmail, Dina Coertzen, Sizwe Tshabalala, Meta Leshabane, Shante da Rocha, Timothy J Egan

ACS Med Chem Lett· March 2025

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Corrigendum to " antiplasmodium and antitrypanosomal activities, β-haematin formation inhibition, molecular docking and DFT computational studies of quinoline-urea-benzothiazole hybrids" [Heliyon Volume 10, Issue 19, October 2024, Article e38434].
Oluwatoba E Oyeneyin, Rashmika Moodley, Chakes Mashaba, Larnelle F Garnie, Damilola A Omoboyowa, Timothy J Egan

Heliyon· December 2024

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antiplasmodium and antitrypanosomal activities, β-haematin formation inhibition, molecular docking and DFT computational studies of quinoline-urea-benzothiazole hybrids.
Oluwatoba E Oyeneyin, Rashmika Moodley, Chakes Mashaba, Larnelle F Garnie, Damilola A Omoboyowa, Timothy J Egan

Heliyon· October 2024

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Discovery of antiplasmodial pyridine carboxamides and thiocarboxamides.
Alexa Redway, Christina Spry, Ainka Brown, Ursula Wiedemann, Imam Fathoni, Timothy J Egan

Int J Parasitol Drugs Drug Resist· August 2024

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Exploring the modulatory influence on the antimalarial activity of amodiaquine using scaffold hybridisation with ferrocene integration.
Mziyanda Mbaba, Taryn M Golding, Reinner O Omondi, Roxanne Mohunlal, Timothy J Egan

Eur J Med Chem· May 2024

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Can virtual reality enhance the patient experience during awake invasive procedures? A systematic review of randomized controlled trials.
Louis Boyce, Chloe Jordan, Timothy Egan, Rajesh Sivaprakasam

Pain· April 2024

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Blood-stage antimalarial activity, favourable metabolic stability and in vivo toxicity of novel piperazine linked 7-chloroquinoline-triazole conjugates.
Amad Uddin, Sonal Gupta, Rumaisha Shoaib, Babita Aneja, Iram Irfan, Timothy J Egan

Eur J Med Chem· January 2024

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The ratio of M1 to M2 microglia in the striatum determines the severity of L-Dopa-induced dyskinesias.
Peggy Rentsch, Timothy Egan, Andrea Kuriakose, Sandy Stayte, Bryce Vissel

J Neurochem· December 2023

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Pyrido-Dibemequine Metabolites Exhibit Improved Druglike Features, Inhibit Hemozoin Formation in , and Synergize with Clinical Antimalarials.
John Okombo, Malkeet Kumar, Devasha Redhi, Kathryn J Wicht, Lubbe Wiesner, Timothy J Egan

ACS Infect Dis· March 2023

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Robust humoral and cellular recall responses to AZD1222 attenuate breakthrough SARS-CoV-2 infection compared to unvaccinated.
Jill Maaske, Stephanie Sproule, Ann R Falsey, Magdalena E Sobieszczyk, Anne F Luetkemeyer, Timothy Egan

Front Immunol· February 2023

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Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches.
Leah Amod, Roxanne Mohunlal, Nicole Teixeira, Timothy J Egan, Kathryn J Wicht

Sci Rep· February 2023

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Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and Efficacy in a Mouse Malaria Infection Model.
Dickson Mambwe, Constance M Korkor, Amanda Mabhula, Zama Ngqumba, Cleavon Cloete, Timothy J Egan

J Med Chem· December 2022

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Arterial cannulation with ultrasound: clinical trial protocol for a randomised controlled trial comparing handheld ultrasound palpation technique for radial artery cannulation.
Valerie Lan-Pak-Kee, Gareth L Ackland, Timothy C Egan, Tom Ef Abbott, Fatima Elsheikh

BJA Open· December 2022

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Adapting a Dialysis Service for Delivery of Percutaneous Arteriovenous Fistulas.
Geoffrey Lie, Niaz Ahmed, Nimesh Shah, Saigeet Eleti, Stefan Lam, Timothy Egan

Radiographics· October 2022

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Rhenium(I) derivatives of aminoquinoline and imidazolopiperidine-based ligands: Synthesis, in vitro and in silico biological evaluation against Plasmodium falciparum.
Sara Nasiri Sovari, Taryn M Golding, Mziyanda Mbaba, Roxanne Mohunlal, Timothy J Egan

J Inorg Biochem· September 2022

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Structural-activity Relationship of Metallo-aminoquines as Next Generation Antimalarials.
Mohammad Abid, Shailja Singh, Timothy J Egan, Mukesh C Joshi

Curr Top Med Chem· May 2022

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THC shows activity against cultured Plasmodium falciparum.
Ana Carolina C de Sousa, Jill M Combrinck, Keletso Maepa, Timothy J Egan

Bioorg Med Chem Lett· December 2021

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Molecular Mechanism Exploration of Potent Fluorinated PI3K Inhibitors with a Triazine Scaffold: Unveiling the Unusual Synergistic Effect of Pyridine-to-Pyrimidine Ring Interconversion and CF Defluorination.
Abdolkarim Farrokhzadeh, Farideh Badichi Akher, Timothy J Egan

J Phys Chem B· September 2021

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Heme Detoxification in the Malaria Parasite: A Target for Antimalarial Drug Development.
Katherine A de Villiers, Timothy J Egan

Acc Chem Res· June 2021

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A Diverse Range of Hemozoin Inhibiting Scaffolds Act on as Heme Complexes.
Roxanne Openshaw, Keletso Maepa, Stefan J Benjamin, Lauren Wainwright, Jill M Combrinck, Timothy J Egan

ACS Infect Dis· February 2021

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Correction to "Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and Efficacy in the NSG Mouse Model".
André Horatscheck, Ana Andrijevic, Aloysius T Nchinda, Claire Le Manach, Tanya Paquet, Timothy J Egan

J Med Chem· February 2021

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