Publications by authors named "Timothy Kern"

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Lysyl Oxidase Promotes Actin-Dependent Neutrophil Activation and Cytotoxicity Toward Retinal Endothelial Cells in Diabetes.
Mahesh Agarwal, Sathishkumar Chandrakumar, Irene Santiago Tierno, Emma M Lessieur, Zak R Bollinger, Timothy S Kern

Diabetes· January 2026

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Lysyl oxidase promotes actin-dependent neutrophil activation and cytotoxicity in diabetes: Implications for diabetic retinopathy.
Mahesh Agarwal, Sathishkumar Chandrakumar, Irene Santiago Tierno, Emma M Lessieur, Zak R Bollinger, Timothy S Kern

bioRxiv· May 2025

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Quantification of Diabetes-induced Adherent Leukocytes in Retinal Vasculature.
Emma M Lessieur, Timothy S Kern

J Vis Exp· January 2025

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Clinical Evidence of a Photoreceptor Origin in Diabetic Retinal Disease.
Rithwick Rajagopal, Timothy Kern

Ophthalmol Sci· August 2024

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Critical Role of CD55 in Controlling Wound Healing.
Lorna Kang, Maryo Kohen, Isaac McCarthy, Emma Hammelef, Hae Suk Kim, Timothy Kern

J Immunol· April 2024

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Mechanical Regulation of Retinal Vascular Inflammation and Degeneration in Diabetes.
Sathishkumar Chandrakumar, Irene Santiago Tierno, Mahesh Agarwal, Emma M Lessieur, Yunpeng Du, Timothy S Kern

Diabetes· February 2024

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Subendothelial Matrix Stiffening by Lysyl Oxidase Enhances RAGE-Mediated Retinal Endothelial Activation in Diabetes.
Sathishkumar Chandrakumar, Irene Santiago Tierno, Mahesh Agarwal, Nikolaos Matisioudis, Timothy S Kern

Diabetes· July 2023

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Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition.
Jennings C Luu, Aicha Saadane, Henri Leinonen, Elliot H Choi, Fangyuan Gao, Timothy S Kern

Proc Natl Acad Sci U S A· May 2023

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CCR2-positive monocytes contribute to the pathogenesis of early diabetic retinopathy in mice.
Aicha Saadane, Alexander A Veenstra, Martin S Minns, Jie Tang, Yunpeng Du, Timothy S Kern

Diabetologia· March 2023

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Diabetic rats with high levels of endogenous dopamine do not show retinal vascular pathology.
Rachael S Allen, Cara T Khayat, Andrew J Feola, Alice S Win, Allison R Grubman, Timothy S Kern

Front Neurosci· March 2023

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ICAM-1 on the luminal surface of endothelial cells is induced to a greater extent in mouse retina than in other tissues in diabetes.
Emma M Lessieur, Haitao Liu, Aicha Saadane, Yunpeng Du, Jianying Kiser, Timothy S Kern

Diabetologia· October 2022

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Defibrinogenation Ameliorates Retinal Microgliosis and Inflammation in A CX3CR1-Independent Manner.
Borna Sarker, Sandra M Cardona, Kaira A Church, Difernando Vanegas, Priscila Velazquez, Timothy S Kern

ASN Neuro· October 2022

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Nanomedicine platform for targeting activated neutrophils and neutrophil-platelet complexes using an α-antitrypsin-derived peptide motif.
Michelle A Cruz, Dillon Bohinc, Elizabeth A Andraska, Jurgis Alvikas, Shruti Raghunathan, Timothy S Kern

Nat Nanotechnol· September 2022

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A Randomized Trial of Photobiomodulation Therapy for Center-Involved Diabetic Macular Edema with Good Visual Acuity (Protocol AE).
Judy E Kim, Adam R Glassman, Kristin Josic, Michele Melia, Lloyd P Aiello, Timothy S Kern

Ophthalmol Retina· April 2022

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Regulation of Adrenergic, Serotonin, and Dopamine Receptors to Inhibit Diabetic Retinopathy: Monotherapies versus Combination Therapies.
Timothy S Kern, Yunpeng Du, Jie Tang, Chieh Allen Lee, Haitao Liu

Mol Pharmacol· November 2021

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Photoreceptor Cell Calcium Dysregulation and Calpain Activation Promote Pathogenic Photoreceptor Oxidative Stress and Inflammation in Prodromal Diabetic Retinopathy.
Aicha Saadane, Yunpeng Du, Wallace B Thoreson, Masaru Miyagi, Emma M Lessieur, Timothy S Kern

Am J Pathol· October 2021

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Neutrophil-Derived Proteases Contribute to the Pathogenesis of Early Diabetic Retinopathy.
Emma M Lessieur, Haitao Liu, Aicha Saadane, Yunpeng Du, Jie Tang, Timothy S Kern

Invest Ophthalmol Vis Sci· October 2021

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Negative regulation of FOXP3 expression by c-Rel O-GlcNAcylation.
Tristan J de Jesus, Jeffrey A Tomalka, Joshua T Centore, Franklin D Staback Rodriguez, Ruchira A Agarwal, Timothy S Kern

Glycobiology· August 2021

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Sildenafil-evoked photoreceptor oxidative stress in vivo is unrelated to impaired visual performance in mice.
Bruce A Berkowitz, Robert H Podolsky, Karen Lins Childers, Aicha Saadane, Timothy S Kern

PLoS One· August 2021

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Photoreceptor cells and RPE contribute to the development of diabetic retinopathy.
Deoye Tonade, Timothy S Kern

Prog Retin Eye Res· July 2021

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A cell-penetrating CD40-TRAF2,3 blocking peptide diminishes inflammation and neuronal loss after ischemia/reperfusion.
Jose-Andres C Portillo, Jin-Sang Yu, Samuel Hansen, Timothy S Kern, M Cecilia Subauste

FASEB J· March 2021

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Formulation and efficacy of ECO/pRHO-ABCA4-SV40 nanoparticles for nonviral gene therapy of Stargardt disease in a mouse model.
Da Sun, Wenyu Sun, Song-Qi Gao, Cheng Wei, Amirreza Naderi, Timothy S Kern

J Control Release· February 2021

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Successful induction of diabetes in mice demonstrates no gender difference in development of early diabetic retinopathy.
Aicha Saadane, Emma M Lessieur, Yunpeng Du, Haitao Liu, Timothy S Kern

PLoS One· November 2020

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All-trans-Retinaldehyde Contributes to Retinal Vascular Permeability in Ischemia Reperfusion.
Alyssa Dreffs, Cheng-Mao Lin, Xuwen Liu, Sumathi Shanmugam, Steven F Abcouwer, Timothy S Kern

Invest Ophthalmol Vis Sci· June 2020

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Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/pDNA Nanoparticles for Specific Gene Delivery in the Retinal Pigment Epithelium.
Da Sun, Rebecca M Schur, Avery E Sears, Song-Qi Gao, Wenyu Sun, Timothy Kern

ACS Appl Bio Mater· May 2020

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