Publications by authors named "Timothy Mosbruger"

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Haplotypic resolution of the challenging genomic regions of MHC and KIR using a combination of targeted sequencing and a novel assembly pipeline.
Timothy L Mosbruger, Amalia Dinou, Jamie L Duke, Deborah Ferriola, Yang Li

Nucleic Acids Res· May 2025

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Targeted and complete genomic sequencing of the major histocompatibility complex in haplotypic form of individual heterozygous samples.
Taishan Hu, Timothy L Mosbruger, Nikolaos G Tairis, Amalia Dinou, Pushkala Jayaraman

Genome Res· October 2024

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The Impact of Patterns in Linkage Disequilibrium and Sequencing Quality on the Imprint of Balancing Selection.
Tristan J Hayeck, Yang Li, Timothy L Mosbruger, Jonathan P Bradfield, Adam G Gleason

Genome Biol Evol· February 2024

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Genomic characterization of HLA class I and class II genes in ethnically diverse sub-Saharan African populations: A report on novel HLA alleles.
Ioanna Pagkrati, Jamie L Duke, Eric Mbunwe, Timothy L Mosbruger, Deborah Ferriola

HLA· August 2023

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A combination of HLA-DP α and β chain polymorphisms paired with a SNP in the DPB1 3' UTR region, denoting expression levels, are associated with atopic dermatitis.
David J Margolis, Jamie L Duke, Nandita Mitra, Ronald A Berna, Ole J Hoffstad, Timothy L Mosbruger

Front Genet· January 2023

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Ancestry adjustment improves genome-wide estimates of regional intolerance.
Tristan J Hayeck, Nicholas Stong, Evan Baugh, Ryan Dhindsa, Tychele N Turner, Timothy L Mosbruger

Genetics· May 2022

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Accurate long-read sequencing allows assembly of the duplicated RHD and RHCE genes harboring variants relevant to blood transfusion.
Zhe Zhang, Hyun Hyung An, Sunitha Vege, Taishan Hu, Shiping Zhang, Timothy Mosbruger

Am J Hum Genet· January 2022

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A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages.
Thomas B Huffaker, H Atakan Ekiz, Cindy Barba, Soh-Hyun Lee, Marah C Runtsch, Timothy L Mosbruger

Nat Commun· May 2021

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Complex Linkage Disequilibrium Effects in HLA-DPB1 Expression and Molecular Mismatch Analyses of Transplantation Outcomes.
Mengkai Shieh, Tristan J Hayeck, Anh Dinh, Jamie L Duke, Nilesh Chitnis, Timothy Mosbruger

Transplantation· March 2021

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Spatial constrains and information content of sub-genomic regions of the human genome.
Leonidas P Karakatsanis, Evgenios G Pavlos, George Tsoulouhas, Georgios L Stamokostas, Timothy Mosbruger

iScience· February 2021

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Genomic characterization of MICA gene using multiple next generation sequencing platforms: A validation study.
Yizhou Zou, Jamie L Duke, Deborah Ferriola, Qizhi Luo, Jenna Wasserman, Timothy L Mosbruger

HLA· October 2020

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AnthOligo: automating the design of oligonucleotides for capture/enrichment technologies.
Pushkala Jayaraman, Timothy Mosbruger, Taishan Hu, Nikolaos G Tairis, Chao Wu

Bioinformatics· August 2020

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Utilizing nanopore sequencing technology for the rapid and comprehensive characterization of eleven HLA loci; addressing the need for deceased donor expedited HLA typing.
Timothy L Mosbruger, Amalia Dinou, Jamie L Duke, Deborah Ferriola, Hilary Mehler

Hum Immunol· August 2020

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Resolving MiSeq-Generated Ambiguities in HLA-DPB1 Typing by Using the Oxford Nanopore Technology.
Jamie L Duke, Timothy L Mosbruger, Deborah Ferriola, Nilesh Chitnis, Taishan Hu

J Mol Diagn· September 2019

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Assessing the utilization of high-resolution 2-field HLA typing in solid organ transplantation.
Yanping Huang, Anh Dinh, Steven Heron, Allison Gasiewski, Carolina Kneib, Timothy Mosbruger

Am J Transplant· July 2019

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Next-generation HLA typing of 382 International Histocompatibility Working Group reference B-lymphoblastoid cell lines: Report from the 17th International HLA and Immunogenetics Workshop.
Lisa E Creary, Sandra G Guerra, Winnie Chong, Colin J Brown, Thomas R Turner, Timothy L Mosbruger

Hum Immunol· July 2019

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Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution.
Vahid Khoddami, Archana Yerra, Timothy L Mosbruger, Aaron M Fleming, Cynthia J Burrows

Proc Natl Acad Sci U S A· April 2019

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Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease.
Marah C Runtsch, Morgan C Nelson, Soh-Hyun Lee, Warren Voth, Margaret Alexander, Timothy Mosbruger

PLoS Genet· February 2019

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FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer.
Soledad A Camolotto, Shrivatsav Pattabiraman, Timothy L Mosbruger, Alex Jones, Veronika K Belova

Elife· November 2018

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The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment.
Gurkan Mollaoglu, Alex Jones, Sarah J Wait, Anandaroop Mukhopadhyay, Sangmin Jeong, Timothy L Mosbruger

Immunity· October 2018

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Characterization of 108 Genomic DNA Reference Materials for 11 Human Leukocyte Antigen Loci: A GeT-RM Collaborative Project.
Maria P Bettinotti, Deborah Ferriola, Jamie L Duke, Timothy L Mosbruger, Nikolaos Tairis

J Mol Diagn· September 2018

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Active BRAF-V600E is the key player in generation of a sessile serrated polyp-specific DNA methylation profile.
Somaye Dehghanizadeh, Vahid Khoddami, Timothy L Mosbruger, Sue S Hammoud, Kornelia Edes

PLoS One· June 2018

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Reversible LSD1 inhibition with HCI-2509 induces the p53 gene expression signature and disrupts the MYCN signature in high-risk neuroblastoma cells.
Sumati Gupta, Kelly Doyle, Timothy L Mosbruger, Andrew Butterfield, Alexis Weston

Oncotarget· February 2018

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Identification of transcriptome signature for myocardial reductive stress.
Justin M Quiles, Madhusudhanan Narasimhan, Timothy Mosbruger, Gobinath Shanmugam, David Crossman

Redox Biol· October 2017

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Mutations Are Associated With Primary Ovarian Insufficiency in Women.
Mika Moriwaki, Barry Moore, Timothy Mosbruger, Deborah W Neklason, Mark Yandell

J Endocr Soc· March 2017

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