Publications by authors named "Timothy Pontz"

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Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases.
Lakshmaiah Gingipalli, Michael H Block, Larry Bao, Emma Cooke, Les A Dakin, Timothy W Pontz

Bioorg Med Chem Lett· May 2018

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Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2.
Matias Casás-Selves, Andrew X Zhang, James E Dowling, Stefan Hallén, Aarti Kawatkar, Timothy Pontz

ChemMedChem· June 2017

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Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo.
James E Dowling, Marat Alimzhanov, Larry Bao, Claudio Chuaqui, Christopher R Denz, Timothy Pontz

ACS Med Chem Lett· March 2016

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Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology.
Jeffrey W Johannes, Lynsie Almeida, Bernard Barlaam, P Ann Boriack-Sjodin, Robert Casella, Timothy Pontz

ACS Med Chem Lett· March 2015

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Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo.
James E Dowling, Marat Alimzhanov, Larry Bao, Michael H Block, Claudio Chuaqui, Timothy W Pontz

ACS Med Chem Lett· August 2013

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Discovery and optimization of a novel series of potent mutant B-Raf(V600E) selective kinase inhibitors.
Melissa M Vasbinder, Brian Aquila, Martin Augustin, Huawei Chen, Tony Cheung, Timothy Pontz

J Med Chem· March 2013

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Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization.
James E Dowling, Claudio Chuaqui, Timothy W Pontz, Paul D Lyne, Nicholas A Larsen

ACS Med Chem Lett· April 2012

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Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent.
Maria-Elena Theoclitou, Brian Aquila, Michael H Block, Patrick J Brassil, Lillian Castriotta, Timothy Pontz

J Med Chem· October 2011

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Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity.
Paul D Lyne, Brian Aquila, Donald J Cook, Les A Dakin, Jay Ezhuthachan, Timothy Pontz

Bioorg Med Chem Lett· February 2009

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Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI).
Juswinder Singh, Claudio E Chuaqui, P Ann Boriack-Sjodin, Wen Cherng Lee, Timothy Pontz

Bioorg Med Chem Lett· December 2003

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