Publications by authors named "Tingkai Chen"

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Seasonal dynamics of C-labeled methanotrophic communities in constructed wetlands of different ages in Taiwan.
Ting-Kai Chen, Yo-Jin Shiau

J Environ Manage· November 2025

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Methane Oxidation Potential and Niche Differentiation of Aerobic Methanotrophs in Coastal Mangrove Forest Soils along a 370 Km Long Coastline in Taiwan.
Yo-Jin Shiau, Ting-Kai Chen, Zhongjun Jia, Chiao-Wen Lin, Chih-Yu Chiu

Environ Sci Technol· August 2025

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Effects of Soil Properties and Seasonal Variations on Microbial Communities in Constructed Wetlands.
Ting-Kai Chen, Yo-Jin Shiau

Microb Ecol· June 2025

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Inhibition of Son of Sevenless Homologue 1 (SOS1): Promising therapeutic treatment for KRAS-mutant cancers.
Tingkai Chen, Xu Tang, Zhenqi Wang, Feng Feng, Chunlei Xu, Yao Chen

Eur J Med Chem· December 2023

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The structural modification and biological evaluation of tetrahydrothienopyridine derivatives as selective BChE inhibitors.
Tingkai Chen, Shenghu Sang, Yuqing Wei, Yujie Ge, Jisheng Jin, Yao Chen

Bioorg Med Chem Lett· September 2023

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The Development and Design Strategy of Leucine-Rich Repeat Kinase 2 Inhibitors: Promising Therapeutic Agents for Parkinson's Disease.
Xu Tang, Shuaishuai Xing, Mingkang Ma, Ziwei Xu, Qianwen Guan, Yuting Chen, Tingkai Chen, Yao Chen

J Med Chem· February 2023

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-Benzyl Benzamide Derivatives as Selective Sub-Nanomolar Butyrylcholinesterase Inhibitors for Possible Treatment in Advanced Alzheimer's Disease.
Chenxi Du, Lei Wang, Qianwen Guan, Hongyu Yang, Tingkai Chen, Ying Chen, Yao Chen

J Med Chem· August 2022

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The Design and Optimization of Monomeric Multitarget Peptides for the Treatment of Multifactorial Diseases.
Tingkai Chen, Tianyu Sun, Yaoyao Bian, Yuqiong Pei, Feng Feng, Chenxi Du, Ying Chen, Yao Chen

J Med Chem· March 2022

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One-stage CNN detector-based benthonic organisms detection with limited training dataset.
Tingkai Chen, Ning Wang, Rongfeng Wang, Hong Zhao, Guichen Zhang

Neural Netw· December 2021

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Discovery of potent glycogen synthase kinase 3/cholinesterase inhibitors with neuroprotection as potential therapeutic agent for Alzheimer's disease.
Xueyang Jiang, Yang Wang, Chang Liu, Caiyi Xing, Yingming Wang, Tingkai Chen, Yao Chen

Bioorg Med Chem· January 2021

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Design, synthesis, and evaluation of benzylpiperidine-linked 1,3-dimethylbenzimidazolinones as cholinesterase inhibitors against Alzheimer's disease.
Jun Mo, Tingkai Chen, Hongyu Yang, Yan Guo, Qi Li, Yao Chen

J Enzyme Inhib Med Chem· December 2020

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Design, Synthesis, and Evaluation of Acetylcholinesterase and Butyrylcholinesterase Dual-Target Inhibitors against Alzheimer's Diseases.
Yan Guo, Hongyu Yang, Zhongwei Huang, Sen Tian, Qihang Li, Chenxi Du, Tingkai Chen

Molecules· January 2020

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Design, synthesis, biological evaluation, and molecular modeling studies of quinoline-ferulic acid hybrids as cholinesterase inhibitors.
Jun Mo, Hongyu Yang, Tingkai Chen, Qihang Li, Hongzhi Lin, Yao Chen

Bioorg Chem· December 2019

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Small molecule modulators targeting protein kinase CK1 and CK2.
Yuting Qiao, Tingkai Chen, Hongyu Yang, Yao Chen, Hongzhi Lin

Eur J Med Chem· November 2019

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Discovery, molecular dynamic simulation and biological evaluation of structurally diverse cholinesterase inhibitors with new scaffold through shape-based pharmacophore virtual screening.
Hongyu Yang, Chenxi Du, Qihang Li, Tingkai Chen, Xin Lu, Yao Chen

Bioorg Chem· November 2019

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CDK8 as a therapeutic target for cancers and recent developments in discovery of CDK8 inhibitors.
Meiyang Xi, Tingkai Chen, Chunlei Wu, Xiaozhong Gao, Yonghua Wu

Eur J Med Chem· February 2019

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Peptide-based and small synthetic molecule inhibitors on PD-1/PD-L1 pathway: A new choice for immunotherapy?
Tingkai Chen, Qi Li, Zongliang Liu, Yao Chen, Feng Feng

Eur J Med Chem· January 2019

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Dual GSK-3β/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer's Disease Drug Discovery.
Xue-Yang Jiang, Ting-Kai Chen, Jun-Ting Zhou, Si-Yu He, Hong-Yu Yang, Yao Chen

ACS Med Chem Lett· March 2018

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