Publications by authors named "Todd B Sells"

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MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors.
Todd B Sells, Ryan Chau, Jeffrey A Ecsedy, Rachel E Gershman, Kara Hoar

ACS Med Chem Lett· June 2015

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Treatment-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924.
Michael A Milhollen, Michael P Thomas, Usha Narayanan, Tary Traore, Jessica Riceberg, Todd B Sells

Cancer Cell· March 2012

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Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905).
Matthew O Duffey, Tricia J Vos, Ruth Adams, Jennifer Alley, Justin Anthony, Todd B Sells

J Med Chem· January 2012

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Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays.
Mark G Manfredi, Jeffrey A Ecsedy, Arijit Chakravarty, Lee Silverman, Mengkun Zhang, Todd B Sells

Clin Cancer Res· December 2011

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Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ.
James E Brownell, Michael D Sintchak, James M Gavin, Hua Liao, Frank J Bruzzese, Todd B Sells

Mol Cell· January 2010

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Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase.
Mark G Manfredi, Jeffrey A Ecsedy, Kristan A Meetze, Suresh K Balani, Olga Burenkova, Todd B Sells

Proc Natl Acad Sci U S A· March 2007

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