Publications by authors named "Ryan Chau"

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Discovery and Optimization of N-Heteroaryl Indazole LRRK2 Inhibitors.
Kaitlyn M Logan, Will Kaplan, Vladimir Simov, Hua Zhou, Derun Li, Ryan Chau

J Med Chem· September 2024

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Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.
David A Candito, Vladimir Simov, Anmol Gulati, Solomon Kattar, Ryan W Chau

J Med Chem· December 2022

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Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors.
Mitchell H Keylor, Anmol Gulati, Solomon D Kattar, Rebecca E Johnson, Ryan W Chau

J Med Chem· January 2022

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Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.
Steven P Langston, Stephen Grossman, Dylan England, Roushan Afroze, Neil Bence, Ryan Chau

J Med Chem· March 2021

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Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor.
Xingyue He, Jessica Riceberg, Teresa Soucy, Erik Koenig, James Minissale, Ryan Chau

Nat Chem Biol· November 2017

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MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors.
Todd B Sells, Ryan Chau, Jeffrey A Ecsedy, Rachel E Gershman, Kara Hoar

ACS Med Chem Lett· June 2015

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Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905).
Matthew O Duffey, Tricia J Vos, Ruth Adams, Jennifer Alley, Justin Anthony, Ryan Chau

J Med Chem· January 2012

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Design and optimization of potent and orally bioavailable tetrahydronaphthalene Raf inhibitors.
Alexandra E Gould, Ruth Adams, Sharmila Adhikari, Kathleen Aertgeerts, Roushan Afroze, Ryan Chau

J Med Chem· March 2011

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Discovery and optimization of pyrazoline compounds as B-Raf inhibitors.
Matthew O Duffey, Ruth Adams, Christopher Blackburn, Ryan W Chau, Susan Chen

Bioorg Med Chem Lett· August 2010

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Localization of the full-thickness cartilage lesions in medial and lateral unicompartmental knee osteoarthritis.
Aashish Gulati, Ryan Chau, David J Beard, Andrew J Price, Harinderjit S Gill

J Orthop Res· October 2009

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Effects of pre- and periconceptional undernutrition on arterial function in adult female sheep are vascular bed dependent.
Christopher Torrens, Tristram H Snelling, Ryan Chau, Meena Shanmuganathan, Jane K Cleal

Exp Physiol· September 2009

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Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood.
Jane K Cleal, Kirsten R Poore, Julian P Boullin, Omar Khan, Ryan Chau

Proc Natl Acad Sci U S A· May 2007

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The approach of fused fissures with fissureless technique decreases the incidence of persistent air leak after lobectomy.
Abel Gómez-Caro, Maria Jose Roca Calvo, Juan Torres Lanzas, Ryan Chau, Pedro Cascales

Eur J Cardiothorac Surg· February 2007

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Identification and structure-activity relationships of a new series of Melanocortin-4 receptor antagonists.
Tricia J Vos, Suresh Balani, Christopher Blackburn, Ryan W Chau, M Diana Danca

Bioorg Med Chem Lett· April 2006

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Fetal origins of coronary heart disease-implications for cardiothoracic surgery?
Omar A Khan, Ryan Chau, Caroline Bertram, Mark A Hanson, Sunil K Ohri

Eur J Cardiothorac Surg· June 2005

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