Publications by authors named "Tom Dunkley"

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Secreted retrovirus-like GAG-domain-containing protein PEG10 is regulated by UBE3A and is involved in Angelman syndrome pathophysiology.
Nikhil J Pandya, Congwei Wang, Veronica Costa, Paul Lopatta, Sonja Meier, Tom Dunkley

Cell Rep Med· August 2021

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MSstatsTMT: Statistical Detection of Differentially Abundant Proteins in Experiments with Isobaric Labeling and Multiple Mixtures.
Ting Huang, Meena Choi, Manuel Tzouros, Sabrina Golling, Nikhil Janak Pandya, Tom Dunkley

Mol Cell Proteomics· October 2020

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MassIVE.quant: a community resource of quantitative mass spectrometry-based proteomics datasets.
Meena Choi, Jeremy Carver, Cristina Chiva, Manuel Tzouros, Ting Huang, Tom Dunkley

Nat Methods· October 2020

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Selection of Features with Consistent Profiles Improves Relative Protein Quantification in Mass Spectrometry Experiments.
Tsung-Heng Tsai, Meena Choi, Balazs Banfai, Yansheng Liu, Brendan X MacLean, Tom Dunkley

Mol Cell Proteomics· June 2020

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N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration.
Chia-Yi Chen, Esther Melo, Peter Jakob, Arno Friedlein, Brigitta Elsässer, Tom Dunkley

Matrix Biol· September 2018

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HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model.
Esther Melo, Philipp Oertle, Carolyn Trepp, Hélène Meistermann, Thomas Burgoyne, Tom Dunkley

EBioMedicine· January 2018

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HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication.
Alvaro Cortes Cabrera, Esther Melo, Doris Roth, Andreas Topp, Frederic Delobel, Tom Dunkley

Sci Rep· November 2017

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mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis.
Veronica Costa, Stefan Aigner, Mirko Vukcevic, Evelyn Sauter, Katharina Behr, Tom Dunkley

Cell Rep· April 2016

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Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome.
Anne L Ashford, Tom P J Dunkley, Mark Cockerill, Rachel A Rowlinson, Lisa M Baak

Cell Mol Life Sci· February 2016

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Characterization of a human pluripotent stem cell-derived model of neuronal development using multiplexed targeted proteomics.
Tom Dunkley, Veronica Costa, Arno Friedlein, Sebastian Lugert, Stefan Aigner

Proteomics Clin Appl· August 2015

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Quantitative ADME proteomics - CYP and UGT enzymes in the Beagle dog liver and intestine.
Aki T Heikkinen, Arno Friedlein, Mariette Matondo, Oliver J D Hatley, Aleksanteri Petsalo, Tom Dunkley

Pharm Res· January 2015

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Targeted profiling of polar intracellular metabolites using ion-pair-high performance liquid chromatography and -ultra high performance liquid chromatography coupled to tandem mass spectrometry: applications to serum, urine and tissue extracts.
Filippos Michopoulos, Nicky Whalley, Georgios Theodoridis, Ian D Wilson, Tom P J Dunkley

J Chromatogr A· July 2014

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AZD3514: a small molecule that modulates androgen receptor signaling and function in vitro and in vivo.
Sarah A Loddick, Sarah J Ross, Andrew G Thomason, David M Robinson, Graeme E Walker, Tom P J Dunkley

Mol Cancer Ther· September 2013

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Putative glycosyltransferases and other plant Golgi apparatus proteins are revealed by LOPIT proteomics.
Nino Nikolovski, Denis Rubtsov, Marcelo P Segura, Godfrey P Miles, Tim J Stevens, Tom P J Dunkley

Plant Physiol· October 2012

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Improved sub-cellular resolution via simultaneous analysis of organelle proteomics data across varied experimental conditions.
Matthew W B Trotter, Pawel G Sadowski, Tom P J Dunkley, Arnoud J Groen, Kathryn S Lilley

Proteomics· December 2010

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Determination of genuine residents of plant endomembrane organelles using isotope tagging and multivariate statistics.
Kathryn S Lilley, Tom P J Dunkley

Methods Mol Biol· August 2008

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Growth control of the eukaryote cell: a systems biology study in yeast.
Juan I Castrillo, Leo A Zeef, David C Hoyle, Nianshu Zhang, Andrew Hayes, Tom Pj Dunkley

J Biol· February 2008

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Quantitative proteomic approach to study subcellular localization of membrane proteins.
Pawel G Sadowski, Tom P J Dunkley, Ian P Shadforth, Paul Dupree, Conrad Bessant

Nat Protoc· October 2007

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Mapping the Arabidopsis organelle proteome.
Tom P J Dunkley, Svenja Hester, Ian P Shadforth, John Runions, Thilo Weimar

Proc Natl Acad Sci U S A· April 2006

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Confident protein identification using the average peptide score method coupled with search-specific, ab initio thresholds.
Ian Shadforth, Tom Dunkley, Kathryn Lilley, Daniel Crowther, Conrad Bessant

Rapid Commun Mass Spectrom· March 2006

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i-Tracker: for quantitative proteomics using iTRAQ.
Ian P Shadforth, Tom P J Dunkley, Kathryn S Lilley, Conrad Bessant

BMC Genomics· October 2005

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A systematic approach to modeling, capturing, and disseminating proteomics experimental data.
Chris F Taylor, Norman W Paton, Kevin L Garwood, Paul D Kirby, David A Stead, Tom Dunkley

Nat Biotechnol· March 2003

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