Publications by authors named "Tomas Simunek"

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Daunorubicin and its hydroxy metabolite in cardiomyocytes: insights into cellular kinetics, toxicity, DNA damage, and dexrazoxane-induced cardioprotection.
Lenka Applová, Paulína Dudášová-Hatoková, Jan Kubeš, Nela Váňová, Veronika Keresteš

Arch Toxicol· September 2025

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Topobexin targets the Topoisomerase II ATPase domain for beta isoform-selective inhibition and anthracycline cardioprotection.
Jan Kubeš, Galina Karabanovich, Anh T Q Cong, Iuliia Melnikova, Olga Lenčová

Nat Commun· May 2025

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Exploring the effects of topoisomerase II inhibitor XK469 on anthracycline cardiotoxicity and DNA damage.
Veronika Keresteš, Jan Kubeš, Lenka Applová, Petra Kollárová, Olga Lenčová-Popelová

Toxicol Sci· March 2024

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Hydrophobicity-enhanced ferritin nanoparticles for efficient encapsulation and targeted delivery of hydrophobic drugs to tumor cells.
Alessio Incocciati, Jan Kubeš, Roberta Piacentini, Chiara Cappelletti, Sofia Botta

Protein Sci· December 2023

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Examination of diverse iron-chelating agents for the protection of differentiated PC12 cells against oxidative injury induced by 6-hydroxydopamine and dopamine.
Pavlína Hašková, Lenka Applová, Hana Jansová, Pavel Homola, Katherine J Franz

Sci Rep· June 2022

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Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up.
Zuzana Pokorná, Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Eduard Jirkovský, Jan Kubeš

Clin Sci (Lond)· January 2022

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Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation.
Eduard Jirkovský, Anna Jirkovská, Hana Bavlovič-Piskáčková, Veronika Skalická, Zuzana Pokorná

Circ Heart Fail· November 2021

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Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo.
Petra Kollárová-Brázdová, Olga Lenčová-Popelová, Galina Karabanovich, Júlia Kocúrová-Lengvarská, Jan Kubeš

Clin Sci (Lond)· August 2021

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Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions.
Anna Jirkovská, Galina Karabanovich, Jan Kubeš, Veronika Skalická, Iuliia Melnikova

J Med Chem· April 2021

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Development of water-soluble prodrugs of the bisdioxopiperazine topoisomerase IIβ inhibitor ICRF-193 as potential cardioprotective agents against anthracycline cardiotoxicity.
Hana Bavlovič Piskáčková, Hana Jansová, Jan Kubeš, Galina Karabanovich, Nela Váňová

Sci Rep· February 2021

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Investigation of Structure-Activity Relationships of Dexrazoxane Analogs Reveals Topoisomerase II Interaction as a Prerequisite for Effective Protection against Anthracycline Cardiotoxicity.
Petra Kollárová-Brázdová, Anna Jirkovská, Galina Karabanovich, Zuzana Pokorná, Hana Bavlovič Piskáčková

J Pharmacol Exp Ther· June 2020

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and investigation of cardiotoxicity associated with anticancer proteasome inhibitors and their combination with anthracycline.
Zuzana Pokorna, Eduard Jirkovsky, Marketa Hlavackova, Hana Jansova, Anna Jirkovska, Tomas Simunek

Clin Sci (Lond)· August 2019

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Cardioprotective Potential of Iron Chelators and Prochelators.
Hana Jansová, Tomáś Šimůnek

Curr Med Chem· April 2019

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Novel SPME fibers based on a plastic support for determination of plasma protein binding of thiosemicarbazone metal chelators: a case example of DpC, an anti-cancer drug that entered clinical trials.
Petra Reimerová, Ján Stariat, Hana Bavlovič Piskáčková, Hana Jansová, Jaroslav Roh

Anal Bioanal Chem· April 2019

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UHPLC-MS/MS method for analysis of sobuzoxane, its active form ICRF-154 and metabolite EDTA-diamide and its application to bioactivation study.
Petra Reimerová, Anna Jirkovská, Hana Bavlovič Piskáčková, Galina Karabanovich, Jaroslav Roh

Sci Rep· March 2019

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2,6-Dihydroxybenzaldehyde Analogues of the Iron Chelator Salicylaldehyde Isonicotinoyl Hydrazone: Increased Hydrolytic Stability and Cytoprotective Activity against Oxidative Stress.
Hana Jansová, Jan Kubeš, Petra Reimerová, Petra Štěrbová-Kovaříková, Jaroslav Roh

Chem Res Toxicol· November 2018

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Binding of an amphiphilic phthalocyanine to pre-formed liposomes confers light-triggered cargo release.
Miloslav Macháček, Kevin A Carter, Filip Kostelanský, Dyego Miranda, Amal Seffouh

J Mater Chem B· November 2018

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Structure-Activity Relationships of Nitro-Substituted Aroylhydrazone Iron Chelators with Antioxidant and Antiproliferative Activities.
Kateřina Hrušková, Eliška Potůčková, Lukáš Opálka, Tereza Hergeselová, Pavlína Hašková

Chem Res Toxicol· June 2018

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Pharmacokinetics of the Cardioprotective Drug Dexrazoxane and Its Active Metabolite ADR-925 with Focus on Cardiomyocytes and the Heart.
Eduard Jirkovský, Anna Jirkovská, Jan Bureš, Jaroslav Chládek, Olga Lenčová

J Pharmacol Exp Ther· March 2018

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Investigation of novel dexrazoxane analogue JR-311 shows significant cardioprotective effects through topoisomerase IIbeta but not its iron chelating metabolite.
Jan Bures, Anna Jirkovska, Vit Sestak, Hana Jansova, Galina Karabanovich, Tomas Simunek

Toxicology· December 2017

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Pharmacy Practice and Education in the Czech Republic.
Petr Nachtigal, Tomáš Šimůnek, Jeffrey Atkinson

Pharmacy (Basel)· October 2017

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Are cardioprotective effects of NO-releasing drug molsidomine translatable to chronic anthracycline cardiotoxicity settings?
Olga Lenčová-Popelová, Hana Jansová, Eduard Jirkovský, Jan Bureš, Anna Jirkovská-Vávrová

Toxicology· November 2016

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Tetra(3,4-pyrido)porphyrazines Caught in the Cationic Cage: Toward Nanomolar Active Photosensitizers.
Miloslav Machacek, Jiri Demuth, Pavel Cermak, Magda Vavreckova, Lenka Hruba, Tomas Simunek

J Med Chem· October 2016

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Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications.
Kateřina Hrušková, Eliška Potůčková, Tereza Hergeselová, Lucie Liptáková, Pavlína Hašková

Eur J Med Chem· September 2016

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Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury.
Pavlína Hašková, Hana Jansová, Jan Bureš, Miloslav Macháček, Anna Jirkovská

Toxicology· September 2016

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