Publications by authors named "Tooru Kimura"

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Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine.
Koushi Hidaka, Tooru Kimura, Rajesh Sankaranarayanan, Jun Wang, Keith F McDaniel

J Med Chem· June 2018

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Structure-guided design and synthesis of P1' position 1-phenylcycloalkylamine-derived pentapeptidic BACE1 inhibitors.
Harichandra D Tagad, Yoshio Hamada, Jeffrey-Tri Nguyen, Koushi Hidaka, Takashi Hamada, Tooru Kimura

Bioorg Med Chem· September 2011

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Development of [Ile⁴⁰]HTLV-I protease inhibition assay using novel fluorogenic and chromogenic substrate.
Henri-Obadja Kumada, Jeffrey-Tri Nguyen, Taeko Kakizawa, Koushi Hidaka, Tooru Kimura

J Pept Sci· August 2011

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S-acyl isopeptide method: use of allyl-type protective group for improved preparation of thioester-containing S-acyl isopeptides by Fmoc-based SPPS.
Taku Yoshiya, Yuka Hasegawa, Wakana Kawamura, Hiroyuki Kawashima, Youhei Sohma, Tooru Kimura

Biopolymers· July 2011

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Design and synthesis of several small-size HTLV-I protease inhibitors with different hydrophilicity profiles.
Jeffrey-Tri Nguyen, Keiko Kato, Koushi Hidaka, Henri-Obadja Kumada, Tooru Kimura

Bioorg Med Chem Lett· April 2011

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Maintaining potent HTLV-I protease inhibition without the P3-cap moiety in small tetrapeptidic inhibitors.
Jeffrey-Tri Nguyen, Keiko Kato, Henri-Obadja Kumada, Koushi Hidaka, Tooru Kimura

Bioorg Med Chem Lett· March 2011

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Epimerization-free synthesis of cyclic peptide by use of the O-acyl isopeptide method.
Taku Yoshiya, Hiroyuki Kawashima, Yuka Hasegawa, Kazuhiro Okamoto, Tooru Kimura

J Pept Sci· August 2010

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Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution.
Takuya Miura, Koushi Hidaka, Tsuyoshi Uemura, Keisuke Kashimoto, Yuto Hori, Tooru Kimura

Bioorg Med Chem Lett· August 2010

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Tetrapeptides, as small-sized peptidic inhibitors; synthesis and their inhibitory activity against BACE1.
Taeko Kakizawa, Koushi Hidaka, Daisuke Hamada, Ryoji Yamaguchi, Tsuyoshi Uemura, Tooru Kimura

J Pept Sci· June 2010

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Design of pentapeptidic BACE1 inhibitors with carboxylic acid bioisosteres at P1' and P4 positions.
Harichandra D Tagad, Yoshio Hamada, Jeffrey-Tri Nguyen, Takashi Hamada, Hamdy Abdel-Rahman, Tooru Kimura

Bioorg Med Chem· May 2010

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Small-sized human immunodeficiency virus type-1 protease inhibitors containing allophenylnorstatine to explore the S2' pocket.
Koushi Hidaka, Tooru Kimura, Hamdy M Abdel-Rahman, Jeffrey-Tri Nguyen, Keith F McDaniel

J Med Chem· December 2009

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Synthesis of amyloid beta peptide 1-42 (E22Delta) click peptide: pH-triggered in situ production of its native form.
Hui Wang, Taeko Kakizawa, Atsuhiko Taniguchi, Takaaki Mizuguchi, Tooru Kimura

Bioorg Med Chem· July 2009

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O-acyl isopeptide method: efficient synthesis of isopeptide segment and application to racemization-free segment condensation.
Taku Yoshiya, Hiroyuki Kawashima, Youhei Sohma, Tooru Kimura, Yoshiaki Kiso

Org Biomol Chem· July 2009

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Racemization-free segment condensation based on the O-acyl isopeptide method: toward a chemical protein synthesis on solid support.
Taku Yoshiya, Youhei Sohma, Yoshio Hamada, Tooru Kimura, Yoshio Hayashi

Adv Exp Med Biol· June 2009

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Application of intramolecular migration reaction in peptide chemistry to chemical biology, chemical pharmaceutics and medicinal chemistry.
Yoshio Hayashi, Yuri Yamazaki, Mariusz Skwarczynski, Youhei Sohma, Atsuhiko Taniguchi, Tooru Kimura

Adv Exp Med Biol· June 2009

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Inhibitory effect of a dimerization-arm-mimetic peptide on EGF receptor activation.
Takaaki Mizuguchi, Hiromasa Uchimura, Taeko Kakizawa, Tooru Kimura, Shigeyuki Yokoyama

Bioorg Med Chem Lett· June 2009

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"Click peptide": pH-triggered in situ production and aggregation of monomer Abeta1-42.
Atsuhiko Taniguchi, Youhei Sohma, Yuta Hirayama, Hidehito Mukai, Tooru Kimura

Chembiochem· March 2009

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Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography.
Motoyasu Adachi, Takashi Ohhara, Kazuo Kurihara, Taro Tamada, Eijiro Honjo, Kaname Kimura, Tooru Kimura

Proc Natl Acad Sci U S A· March 2009

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Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin.
Koushi Hidaka, Tooru Kimura, Adam J Ruben, Tsuyoshi Uemura, Mami Kamiya

Bioorg Med Chem· December 2008

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Controlled production of amyloid beta peptide from a photo-triggered, water-soluble precursor "click peptide".
Atsuhiko Taniguchi, Mariusz Skwarczynski, Youhei Sohma, Takuma Okada, Keisuke Ikeda, Tooru Kimura

Chembiochem· December 2008

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Isopeptide method: development of S-acyl isopeptide method for the synthesis of difficult sequence-containing peptides.
Taku Yoshiya, Nui Ito, Tooru Kimura, Yoshiaki Kiso

J Pept Sci· November 2008

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Crystallization and preliminary neutron diffraction studies of HIV-1 protease cocrystallized with inhibitor KNI-272.
Hiroyoshi Matsumura, Motoyasu Adachi, Shigeru Sugiyama, Shino Okada, Megumi Yamakami, Tooru Kimura

Acta Crystallogr Sect F Struct Biol Cryst Commun· November 2008

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Design of potent aspartic protease inhibitors to treat various diseases.
Jeffrey-Tri Nguyen, Yoshio Hamada, Tooru Kimura, Yoshiaki Kiso

Arch Pharm (Weinheim)· September 2008

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Locking the two ends of tetrapeptidic HTLV-I protease inhibitors inside the enzyme.
Meihui Zhang, Jeffrey-Tri Nguyen, Henri-Obadja Kumada, Tooru Kimura, Maosheng Cheng

Bioorg Med Chem· July 2008

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Development of novel water-soluble photocleavable protective group and its application for design of photoresponsive paclitaxel prodrugs.
Mayo Noguchi, Mariusz Skwarczynski, Halan Prakash, Shun Hirota, Tooru Kimura

Bioorg Med Chem· May 2008

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