Publications by authors named "Travis Lear"

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NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β-TrCP1/FBXO5 Axis.
Yao Tong, Travis B Lear, Ferhan Tuncer, John J Villandre, Áine N Boudreau

Adv Sci (Weinh)· September 2025

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Inhibition of virally induced TFEB proteasomal degradation as a host-centric therapeutic approach for coronaviral infection.
Travis B Lear, Mads B Larsen, Bo Lin, Benjamin R Treat, Qing Cao

Sci Adv· June 2025

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E3 ubiquitin ligase ZBTB25 suppresses beta coronavirus infection through ubiquitination of the main viral protease MPro.
Travis B Lear, Áine N Boudreau, Karina C Lockwood, Elise Chu, Daniel P Camarco

J Biol Chem· December 2023

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KIAA0317 regulates SOCS1 stability to ameliorate colonic inflammation.
Karina C Lockwood, Travis B Lear, Shristi Rajbhandari, Alison C McKelvey, Sarah R Dunn

FEBS J· August 2023

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Fibronectin-EDA accumulates via reduced ubiquitination downstream of Toll-like receptor 9 activation in SSc-ILD fibroblasts.
Ferhan Tuncer, Melissa Bulik, John Villandre, Travis Lear, Yanwen Chen

Am J Physiol Lung Cell Mol Physiol· October 2022

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Senolytic vaccination: a new mandate for cardiovascular health?
Travis B Lear, Toren Finkel

J Cardiovasc Aging· April 2022

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A Repurposed Drug Screen for Compounds Regulating Aquaporin 5 Stability in Lung Epithelial Cells.
John Villandre, Virginia White, Travis B Lear, Yanwen Chen, Ferhan Tuncer

Front Pharmacol· January 2022

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A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry.
Yanwen Chen, Travis B Lear, John W Evankovich, Mads B Larsen, Bo Lin

Nat Commun· June 2021

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Modulation of lysosomal function as a therapeutic approach for coronaviral infections.
Yuan Liu, Travis Lear, Mads Larsen, Bo Lin, Qing Cao

Res Sq· April 2021

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A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance.
Yuan Liu, Michael J Jurczak, Travis B Lear, Bo Lin, Mads B Larsen

Nat Chem Biol· March 2021

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A high throughput screen for TMPRSS2 expression identifies FDA-approved and clinically advanced compounds that can limit SARS-CoV-2 entry.
Yanwen Chen, Travis B Lear, John W Evankovich, Mads B Larsen, Bo Lin

Res Sq· August 2020

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Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1.
Yuan Liu, Travis B Lear, Manish Verma, Kent Zq Wang, P Anthony Otero

JCI Insight· June 2020

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A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis.
Yanwen Chen, John W Evankovich, Travis B Lear, Ferhan Tuncer, Jason R Kennerdell

Redox Biol· May 2020

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Kelch-like protein 42 is a profibrotic ubiquitin E3 ligase involved in systemic sclerosis.
Travis B Lear, Karina C Lockwood, Mads Larsen, Ferhan Tuncer, Jason R Kennerdell

J Biol Chem· March 2020

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Toll-like Receptor 8 Stability Is Regulated by Ring Finger 216 in Response to Circulating MicroRNAs.
John Evankovich, Travis Lear, Courtney Baldwin, Yanwen Chen, Virginia White

Am J Respir Cell Mol Biol· February 2020

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The RNFT2/IL-3Rα axis regulates IL-3 signaling and innate immunity.
Yao Tong, Travis B Lear, John Evankovich, Yanwen Chen, James D Londino

JCI Insight· February 2020

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The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing.
Travis B Lear, Karina C Lockwood, Yurong Ouyang, John W Evankovich, Mads B Larsen

J Biol Chem· November 2019

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KIAA0317 regulates pulmonary inflammation through SOCS2 degradation.
Travis B Lear, Alison C McKelvey, John W Evankovich, Shristi Rajbhandari, Tiffany A Coon

JCI Insight· October 2019

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RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling.
Travis Lear, Sarah R Dunn, Alison C McKelvey, Aazrin Mir, John Evankovich

Am J Physiol Cell Physiol· November 2017

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Post-translational modification of the interferon-gamma receptor alters its stability and signaling.
James D Londino, Dexter L Gulick, Travis B Lear, Tomeka L Suber, Nathaniel M Weathington

Biochem J· October 2017

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Receptor for advanced glycation end products is targeted by FBXO10 for ubiquitination and degradation.
John Evankovich, Travis Lear, Alison Mckelvey, Sarah Dunn, James Londino

FASEB J· September 2017

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Therapeutic targets in fibrotic pathways.
Travis Lear, Bill B Chen

Cytokine· December 2016

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RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity.
Alison C McKelvey, Travis B Lear, Sarah R Dunn, John Evankovich, James D Londino

Elife· November 2016

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Crystal structure and interaction studies of the human FBxo3 ApaG domain.
Troy C Krzysiak, Bill B Chen, Travis Lear, Rama K Mallampalli, Angela M Gronenborn

FEBS J· June 2016

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Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4.
Travis Lear, Alison C McKelvey, Shristi Rajbhandari, Sarah R Dunn, Tiffany A Coon

J Exp Med· May 2016

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