Publications by authors named "Umender Sharma"

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Antimicrobial activity of Mycobacteriophage D29 Lysin B during Mycobacterium ulcerans infection.
Alexandra G Fraga, Gabriela Trigo, Ramya K Murthy, Shamim Akhtar, Madhavi Hebbur, Umender Sharma

PLoS Negl Trop Dis· August 2019

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Phage-derived lysins as potential agents for eradicating biofilms and persisters.
Umender Sharma, Aradhana Vipra, Shankaramurthy Channabasappa

Drug Discov Today· April 2018

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Restoration of sensitivity of a diverse set of drug-resistant Staphylococcus clinical strains by bactericidal protein P128.
Sandhya Nair, Nethravathi Poonacha, Srividya Desai, Deepika Hiremath, Darshan Tuppad, Umender Sharma

J Med Microbiol· March 2018

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Efficient Killing of Planktonic and Biofilm-Embedded Coagulase-Negative Staphylococci by Bactericidal Protein P128.
Nethravathi Poonacha, Sandhya Nair, Srividya Desai, Darshan Tuppad, Deepika Hiremath, Umender Sharma

Antimicrob Agents Chemother· August 2017

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Bacteriophage lysins as antibacterials.
Umender Sharma, Vivek D Paul

Crit Care· May 2017

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Antibiofilm Activity and Synergistic Inhibition of Staphylococcus aureus Biofilms by Bactericidal Protein P128 in Combination with Antibiotics.
Sandhya Nair, Srividya Desai, Nethravathi Poonacha, Aradhana Vipra, Umender Sharma

Antimicrob Agents Chemother· December 2016

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An IPTG Inducible Conditional Expression System for Mycobacteria.
Sudha Ravishankar, Anisha Ambady, Haripriya Ramu, Naina Vinay Mudugal, Ragadeepthi Tunduguru, Umender K Sharma

PLoS One· May 2016

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Genetic and chemical validation identifies Mycobacterium tuberculosis topoisomerase I as an attractive anti-tubercular target.
Sudha Ravishankar, Anisha Ambady, Disha Awasthy, Naina Vinay Mudugal, Sreenivasaiah Menasinakai, Sreevalli Sharma, Umender K Sharma

Tuberculosis (Edinb)· September 2015

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Revisiting the essentiality of glutamate racemase in Mycobacterium tuberculosis.
Sapna Morayya, Disha Awasthy, Reena Yadav, Anisha Ambady, Umender Sharma

Gene· January 2015

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Bacteriophage-derived CHAP domain protein, P128, kills Staphylococcus cells by cleaving interpeptide cross-bridge of peptidoglycan.
Sudarson Sundarrajan, Junjappa Raghupatil, Aradhana Vipra, Nagalakshmi Narasimhaswamy, Sanjeev Saravanan, Umender Sharma

Microbiology (Reading)· October 2014

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Roles of the two type II NADH dehydrogenases in the survival of Mycobacterium tuberculosis in vitro.
Disha Awasthy, Anisha Ambady, Ashwini Narayana, Sapna Morayya, Umender Sharma

Gene· October 2014

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Novel N-linked aminopiperidine-based gyrase inhibitors with improved hERG and in vivo efficacy against Mycobacterium tuberculosis.
Shahul Hameed P, Vikas Patil, Suresh Solapure, Umender Sharma, Prashanti Madhavapeddi, Sreevalli Sharma

J Med Chem· June 2014

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Evaluation of CoA biosynthesis proteins of Mycobacterium tuberculosis as potential drug targets.
Anisha Ambady, Disha Awasthy, Reena Yadav, Santhoshi Basuthkar, Kothandaraman Seshadri, Umender Sharma

Tuberculosis (Edinb)· November 2012

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Efflux pumps of Mycobacterium tuberculosis play a significant role in antituberculosis activity of potential drug candidates.
Meenakshi Balganesh, Neela Dinesh, Sreevalli Sharma, Sanjana Kuruppath, Anju V Nair, Umender Sharma

Antimicrob Agents Chemother· May 2012

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Alanine racemase mutants of Mycobacterium tuberculosis require D-alanine for growth and are defective for survival in macrophages and mice.
Disha Awasthy, Sowmya Bharath, Venkita Subbulakshmi, Umender Sharma

Microbiology (Reading)· February 2012

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Current possibilities and unresolved issues of drug target validation in Mycobacterium tuberculosis.
Umender Sharma

Expert Opin Drug Discov· November 2011

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Rv1218c, an ABC transporter of Mycobacterium tuberculosis with implications in drug discovery.
Meenakshi Balganesh, Sanjana Kuruppath, Nimi Marcel, Sreevalli Sharma, Anju Nair, Umender Sharma

Antimicrob Agents Chemother· December 2010

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Transcriptional switching in Escherichia coli during stress and starvation by modulation of sigma activity.
Umender K Sharma, Dipankar Chatterji

FEMS Microbiol Rev· September 2010

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Essentiality and functional analysis of type I and type III pantothenate kinases of Mycobacterium tuberculosis.
Disha Awasthy, Anisha Ambady, Jyothi Bhat, Gulebahar Sheikh, Sudha Ravishankar, Umender Sharma

Microbiology (Reading)· September 2010

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Inactivation of the ilvB1 gene in Mycobacterium tuberculosis leads to branched-chain amino acid auxotrophy and attenuation of virulence in mice.
Disha Awasthy, Sheshagiri Gaonkar, R K Shandil, Reena Yadav, Sowmya Bharath, Umender Sharma

Microbiology (Reading)· September 2009

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Differential mechanisms of binding of anti-sigma factors Escherichia coli Rsd and bacteriophage T4 AsiA to E. coli RNA polymerase lead to diverse physiological consequences.
Umender K Sharma, Dipankar Chatterji

J Bacteriol· May 2008

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High-throughput screening of RNA polymerase inhibitors using a fluorescent UTP analog.
Jyothi Bhat, Rajendra Rane, Suresh M Solapure, Dhiman Sarkar, Umender Sharma

J Biomol Screen· December 2006

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Both regions 4.1 and 4.2 of E. coli sigma(70) are together required for binding to bacteriophage T4 AsiA in vivo.
Umender K Sharma, Dipankar Chatterji

Gene· July 2006

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Mutational analysis of bacteriophage T4 AsiA: involvement of N- and C-terminal regions in binding to sigma(70) of Escherichia coli in vivo.
Umender K Sharma, P V K Praveen, T S Balganesh

Gene· July 2002

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