Publications by authors named "Varman Samuel"

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Cideb knockdown in mice increases mitochondrial fat oxidation and reverses hepatic steatosis and insulin resistance by the plasma membrane sn-1,2-DAGs-PKCε-insulin receptor kinase pathway.
Jie Zheng, Rafael C Gaspar, Ikki Sakuma, Brandon T Hubbard, Dongyan Zhang, Varman T Samuel

Diabetologia· December 2025

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Hepatic ferredoxin reductase modulates mitochondrial function and iron homeostasis in metabolic dysfunction-associated steatotic liver disease.
Tomoaki Tanaka, Ikki Sakuma, Rafael Gaspar, Panu Luukkonen, Brandon Hubbard, Varman Samuel

Res Sq· August 2025

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Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis.
Ikki Sakuma, Rafael C Gaspar, Ali R Nasiri, Sylvie Dufour, Mario Kahn, Varman T Samuel

Proc Natl Acad Sci U S A· May 2025

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Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis.
Ikki Sakuma, Rafael C Gaspar, Ali R Nasiri, Sylvie Dufour, Mario Kahn, Varman T Samuel

bioRxiv· March 2025

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High-fat-diet-induced hepatic insulin resistance attenuates murine lipogenesis.
Leigh Goedeke, Jordan W Strober, Rebecca Suh, Lauren M Paolella, Xiruo Li, Varman T Samuel

iScience· November 2024

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Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCε-insulin receptor phosphorylation pathway.
Weiwei Xu, Dongyan Zhang, Yumin Ma, Rafael C Gaspar, Mario Kahn, Varman T Samuel

Cell Rep· October 2024

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Author Correction: Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner.
Utpal B Pajvani, Carrie J Shawber, Varman T Samuel, Andreas L Birkenfeld, Gerald I Shulman

Nat Med· February 2024

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Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition.
Ikki Sakuma, Rafael C Gaspar, Panu K Luukkonen, Mario Kahn, Dongyan Zhang, Varman T Samuel

Proc Natl Acad Sci U S A· December 2023

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Deletion of gene causes early growth retardation and insulin resistance in mice.
Hui-Young Lee, Hye Rim Jang, Hui Li, Varman T Samuel, Karrie D Dudek

Proc Natl Acad Sci U S A· December 2022

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Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol/PKCε/insulin receptor Thr1160 phosphorylation.
Kun Lyu, Dongyan Zhang, Joongyu Song, Xiruo Li, Rachel J Perry, Varman T Samuel

JCI Insight· February 2021

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Membrane-bound -1,2-diacylglycerols explain the dissociation of hepatic insulin resistance from hepatic steatosis in MTTP knockout mice.
Abudukadier Abulizi, Daniel F Vatner, Zhang Ye, Yongliang Wang, Joao-Paulo Camporez, Varman T Samuel

J Lipid Res· December 2020

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A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance.
Kun Lyu, Ye Zhang, Dongyan Zhang, Mario Kahn, Kasper W Ter Horst, Varman T Samuel

Cell Metab· October 2020

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Metabolic control analysis of hepatic glycogen synthesis in vivo.
Yuichi Nozaki, Max C Petersen, Dongyan Zhang, Daniel F Vatner, Rachel J Perry, Varman T Samuel

Proc Natl Acad Sci U S A· April 2020

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Considering the Links Between Nonalcoholic Fatty Liver Disease and Insulin Resistance: Revisiting the Role of Protein Kinase C ε.
Varman T Samuel, Max C Petersen, Brandon M Gassaway, Daniel F Vatner, Jesse Rinehart

Hepatology· December 2019

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Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production.
Brandon M Gassaway, Rebecca L Cardone, Anil K Padyana, Max C Petersen, Evan T Judd, Varman T Samuel

Cell Rep· December 2019

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Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Ceramides.
Varman T Samuel, Gerald I Shulman

N Engl J Med· November 2019

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Adipose glucocorticoid action influences whole-body metabolism modulation of hepatic insulin action.
Abudukadier Abulizi, João-Paulo Camporez, Michael J Jurczak, Kasper F Høyer, Dongyan Zhang, Varman T Samuel

FASEB J· July 2019

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Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-hydroxysteroid dehydrogenase type 1 transgenic mice.
Abudukadier Abulizi, João-Paulo Camporez, Dongyan Zhang, Varman T Samuel, Gerald I Shulman

Metabolism· April 2019

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PEPCK1 Antisense Oligonucleotide Prevents Adiposity and Impairs Hepatic Glycogen Synthesis in High-Fat Male Fed Rats.
Sara A Beddow, Arijeet K Gattu, Daniel F Vatner, Lauren Paolella, Abdulelah Alqarzaee, Varman T Samuel

Endocrinology· January 2019

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PKCε contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling.
Brandon M Gassaway, Max C Petersen, Yulia V Surovtseva, Karl W Barber, Joshua B Sheetz, Varman T Samuel

Proc Natl Acad Sci U S A· September 2018

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Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents.
Daniel F Vatner, Leigh Goedeke, Joao-Paulo G Camporez, Kun Lyu, Ali R Nasiri, Varman T Samuel

Diabetologia· June 2018

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Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases.
Varman T Samuel, Gerald I Shulman

Cell Metab· January 2018

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Mitochondrial-Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation.
Hui-Young Lee, Jae Sung Lee, Tiago Alves, Warren Ladiges, Peter S Rabinovitch, Varman T Samuel

Diabetes· August 2017

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Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans.
Kasper W Ter Horst, Pim W Gilijamse, Ruth I Versteeg, Mariette T Ackermans, Aart J Nederveen, Varman T Samuel

Cell Rep· June 2017

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Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance.
Max C Petersen, Anila K Madiraju, Brandon M Gassaway, Michael Marcel, Ali R Nasiri, Varman T Samuel

J Clin Invest· November 2016

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