Publications by authors named "Venkatesh Pilla-Reddy"

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Postmarketing Assessment of Antibody-Drug Conjugates: Proof-of-Concept Using Model-Based Meta-Analysis and a Clinical Utility Index Approach.
Innocent Gerald Asiimwe, Nour Chtiba, Samer Mouksassi, Goonaseelan Colin Pillai, Raimund M Peter

CPT Pharmacometrics Syst Pharmacol· November 2025

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Achieving human brain exposure with the oral ataxia-telangiectasia mutated kinase inhibitor AZD1390, a substrate of aldehyde oxidase.
Nicola Colclough, Alexandra L Orton, Scott Martin, Martin Wild, Venkatesh Pilla Reddy

Drug Metab Dispos· August 2025

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ICH M12 Drug Interaction Studies: Summary of the Efforts to Achieve Global Convergence.
Kellie Reynolds, Xinning Yang, Sheila Annie Peters, Vikram Sinha, Helen Heymann

Clin Pharmacol Ther· July 2025

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Building Confidence in Physiologically Based Pharmacokinetic Modeling of CYP3A Induction Mediated by Rifampin: An Industry Perspective.
Micaela B Reddy, Tamara D Cabalu, Loeckie de Zwart, Diane Ramsden, Martin E Dowty

Clin Pharmacol Ther· February 2025

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Physiologically Based Pharmacokinetic modelling of drugs in pregnancy: A mini-review on availability and limitations.
Monika Berezowska, Pradeep Sharma, Venkatesh Pilla Reddy, Paola Coppola

Fundam Clin Pharmacol· June 2024

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Safety, tolerability, and pharmacokinetics of half-life extended SARS-CoV-2-neutralizing monoclonal antibodies AZD7442 (tixagevimab/cilgavimab) in healthy Japanese adults.
Hiroshi Okada, Kensuke Ishikawa, Yohji Itoh, Yoshinori Noda, Takashi Eto

J Infect Chemother· November 2023

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Outpatient Treatment with AZD7442 (Tixagevimab/Cilgavimab) Prevented COVID-19 Hospitalizations over 6 Months and Reduced Symptom Progression in the TACKLE Randomized Trial.
F D Richard Hobbs, Hugh Montgomery, Francisco Padilla, Jesus Abraham Simón-Campos, Kenneth Kim

Infect Dis Ther· September 2023

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Interlaboratory Variability in the Madin-Darby Canine Kidney Cell Proteome.
Matthew D Harwood, Katharina Zettl, Manuel Weinheimer, Venkatesh Pilla-Reddy, Hong Shen

Mol Pharm· July 2023

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Safety, Tolerability and Pharmacokinetics of Half-Life Extended Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Monoclonal Antibodies AZD7442 (Tixagevimab-Cilgavimab) in Healthy Adults.
Pablo Forte-Soto, Muna Albayaty, Dennis Brooks, Rosalinda H Arends, John Tillinghast

J Infect Dis· May 2023

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Application of Modelling and Simulation Approaches to Predict Pharmacokinetics of Therapeutic Monoclonal Antibodies in Pediatric Population.
Andrew Lim, Pradeep Sharma, Oleg Stepanov, Venkatesh Pilla Reddy

Pharmaceutics· May 2023

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Evaluating the performance of machine-learning regression models for pharmacokinetic drug-drug interactions.
Jaidip Gill, Marie Moullet, Anton Martinsson, Filip Miljković, Beth Williamson

CPT Pharmacometrics Syst Pharmacol· January 2023

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Comparative Pharmacokinetics of Tixagevimab/Cilgavimab (AZD7442) Administered Intravenously Versus Intramuscularly in Symptomatic SARS-CoV-2 Infection.
Rachel A Bender Ignacio, David A Wohl, Rosalin Arends, Venkatesh Pilla Reddy, Ying Mu

Clin Pharmacol Ther· December 2022

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Comparing the applications of machine learning, PBPK, and population pharmacokinetic models in pharmacokinetic drug-drug interaction prediction.
Jaidip Gill, Marie Moullet, Anton Martinsson, Filip Miljković, Beth Williamson

CPT Pharmacometrics Syst Pharmacol· December 2022

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Current Practices, Gap Analysis, and Proposed Workflows for PBPK Modeling of Cytochrome P450 Induction: An Industry Perspective.
Niresh Hariparsad, Diane Ramsden, Kunal Taskar, Justine Badée, Karthik Venkatakrishnan

Clin Pharmacol Ther· October 2022

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Development of and insights from systems pharmacology models of antibody-drug conjugates.
Inez Lam, Venkatesh Pilla Reddy, Kathryn Ball, Rosalinda H Arends, Feilim Mac Gabhann

CPT Pharmacometrics Syst Pharmacol· August 2022

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Harnessing Clinical Trial and Real-World Data Towards an Understanding of Sex Effects on Drug Pharmacokinetics, Pharmacodynamics and Efficacy.
Joyce Oi Yan Chan, Marie Moullet, Beth Williamson, Rosalinda H Arends, Venkatesh Pilla Reddy

Front Pharmacol· June 2022

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The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans.
Yueh-Ming Loo, Patrick M McTamney, Rosalinda H Arends, Michael E Abram, Anastasia A Aksyuk

Sci Transl Med· March 2022

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Unraveling pleiotropic effects of rifampicin by using physiologically based pharmacokinetic modeling: Assessing the induction magnitude of P-glycoprotein-cytochrome P450 3A4 dual substrates.
Xian Pan, Shinji Yamazaki, Sibylle Neuhoff, Mian Zhang, Venkatesh Pilla Reddy

CPT Pharmacometrics Syst Pharmacol· December 2021

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Food constituent- and herb-drug interactions in oncology: Influence of quantitative modelling on Drug labelling.
Venkatesh Pilla Reddy, Heeseung Jo, Sibylle Neuhoff

Br J Clin Pharmacol· October 2021

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Mechanistic physiology-based pharmacokinetic modeling to elucidate vincristine-induced peripheral neuropathy following treatment with novel kinase inhibitors.
Venkatesh Pilla Reddy, Adrian J Fretland, Diansong Zhou, Shringi Sharma, Buyun Chen

Cancer Chemother Pharmacol· September 2021

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Optimization of an Imidazo[1,2-]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with Efficacy.
William McCoull, Scott Boyd, Martin R Brown, Muireann Coen, Olga Collingwood

J Med Chem· September 2021

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ALT neuroblastoma chemoresistance due to telomere dysfunction-induced ATM activation is reversible with ATM inhibitor AZD0156.
Balakrishna Koneru, Ahsan Farooqi, Thinh H Nguyen, Wan Hsi Chen, Ashly Hindle

Sci Transl Med· August 2021

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Tumour-on-chip microfluidic platform for assessment of drug pharmacokinetics and treatment response.
Tudor Petreus, Elaine Cadogan, Gareth Hughes, Aaron Smith, Venkatesh Pilla Reddy

Commun Biol· August 2021

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Blood retinal barrier and ocular pharmacokinetics: Considerations for the development of oncology drugs.
Beth Williamson, Venkatesh Pilla Reddy

Biopharm Drug Dispos· April 2021

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Special issue on applications of modeling and simulation in pharmaceutical drug development.
Venkatesh Pilla Reddy

Biopharm Drug Dispos· April 2021

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