Publications by authors named "Verena Linhard"

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Structural Role of Conformational Heterogeneity and Juxtamembrane Regions in the Ephrin A1 Interactions With the EphA2 Receptor Ligand-binding Domain.
Konstantin S Mineev, Santosh L Gande, Annika Wenzel, Verena Linhard, Halle Andrews-Clark

J Mol Biol· December 2025

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Structure-Based Rational Design of a Selective Hydrolase Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus-2 Nsp3 Macrodomain.
Robin Krishnathas, Konstantin S Mineev, Nikolaos K Fourkiotis, Franck Touret, Christos Sideras-Bisdekis, Verena Linhard

Chembiochem· November 2025

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NMR resonance assignment of a ligand-binding domain of ephrin receptor A2.
Konstantin S Mineev, Santosh L Gande, Verena Linhard, Sattar Khashkhashi Moghaddam, Harald Schwalbe

Biomol NMR Assign· June 2025

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Targeting the Main Protease (M, nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies.
Nadide Altincekic, Nathalie Jores, Frank Löhr, Christian Richter, Claus Ehrhardt, Verena Linhard

ACS Chem Biol· February 2024

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Modulation of Aβ42 Aggregation Kinetics and Pathway by Low-Molecular-Weight Inhibitors.
Marie-Theres Hutchison, Giovanni Bellomo, Alexey Cherepanov, Elke Stirnal, Boris Fürtig, Verena Linhard

Chembiochem· April 2023

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Optimization of the Lead Compound NVP-BHG712 as a Colorectal Cancer Inhibitor.
Alix Tröster, Michael DiPrima, Nathalie Jores, Denis Kudlinzki, Sridhar Sreeramulu, Verena Linhard

Chemistry· April 2023

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The MECP2-TRD domain interacts with the DNMT3A-ADD domain at the H3-tail binding site.
Stefan Kunert, Verena Linhard, Sara Weirich, Michel Choudalakis, Florian Osswald

Protein Sci· January 2023

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Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug Development.
Hannes Berg, Maria A Wirtz Martin, Nadide Altincekic, Islam Alshamleh, Jasleen Kaur Bains, Verena Linhard

Angew Chem Int Ed Engl· November 2022

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Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators.
Jan Heering, Nathalie Jores, Whitney Kilu, Espen Schallmayer, Evelyn Peelen, Verena Linhard

ACS Chem Biol· November 2022

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Binding Adaptation of GS-441524 Diversifies Macro Domains and Downregulates SARS-CoV-2 de-MARylation Capacity.
Aikaterini C Tsika, Angelo Gallo, Nikolaos K Fourkiotis, Aikaterini I Argyriou, Sridhar Sreeramulu, Verena Linhard

J Mol Biol· August 2022

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Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications.
Nadide Altincekic, Sophie Marianne Korn, Nusrat Shahin Qureshi, Marie Dujardin, Martí Ninot-Pedrosa, Verena Linhard

Front Mol Biosci· May 2021

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Molecular tuning of farnesoid X receptor partial agonism.
Daniel Merk, Sridhar Sreeramulu, Denis Kudlinzki, Krishna Saxena, Verena Linhard

Nat Commun· July 2019

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On the Implication of Water on Fragment-to-Ligand Growth in Kinase Binding Thermodynamics.
Barbara Wienen-Schmidt, Tobias Wulsdorf, Hendrik R A Jonker, Krishna Saxena, Denis Kudlinzki, Verena Linhard

ChemMedChem· September 2018

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NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family.
Alix Tröster, Stephanie Heinzlmeir, Benedict-Tilman Berger, Santosh L Gande, Krishna Saxena, Verena Linhard

ChemMedChem· August 2018

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The domain architecture of PtkA, the first tyrosine kinase from , differs from the conventional kinase architecture.
Anna Niesteruk, Hendrik R A Jonker, Christian Richter, Verena Linhard, Sridhar Sreeramulu

J Biol Chem· July 2018

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Siobhan E Toal, Nina Kubatova, Christian Richter, Verena Linhard, Harald Schwalbe

Chemistry· December 2017

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Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
Stephanie Heinzlmeir, Jonas Lohse, Tobias Treiber, Denis Kudlinzki, Verena Linhard

ChemMedChem· June 2017

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Expression and Purification of EPHA2 Tyrosine Kinase Domain for Crystallographic and NMR Studies.
Santosh L Gande, Krishna Saxena, Sridhar Sreeramulu, Verena Linhard, Denis Kudlinzki

Chembiochem· December 2016

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Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
Stephanie Heinzlmeir, Denis Kudlinzki, Sridhar Sreeramulu, Susan Klaeger, Santosh Lakshmi Gande, Verena Linhard

ACS Chem Biol· December 2016

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High-resolution crystal structure of cAMP-dependent protein kinase from Cricetulus griseus.
Denis Kudlinzki, Verena L Linhard, Krishna Saxena, Sridhar Sreeramulu, Santosh Gande

Acta Crystallogr F Struct Biol Commun· August 2015

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Structure and Biophysical Characterization of the S-Adenosylmethionine-dependent O-Methyltransferase PaMTH1, a Putative Enzyme Accumulating during Senescence of Podospora anserina.
Deep Chatterjee, Denis Kudlinzki, Verena Linhard, Krishna Saxena, Ulrich Schieborr

J Biol Chem· June 2015

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Randomizing the unfolded state of peptides (and proteins) by nearest neighbor interactions between unlike residues.
Siobhan E Toal, Nina Kubatova, Christian Richter, Verena Linhard, Harald Schwalbe

Chemistry· March 2015

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Vinorine synthase from Rauvolfia: the first example of crystallization and preliminary X-ray diffraction analysis of an enzyme of the BAHD superfamily.
Xueyan Ma, Juergen Koepke, Anja Bayer, Verena Linhard, Günter Fritzsch

Biochim Biophys Acta· September 2004

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