Publications by authors named "Victor J Hruby"

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Design, Structure-Activity Relationships, and Computational Modeling Studies of a Series of α-Helix Biased, Ultra-Short Glucagon-like Peptide-1 Receptor Agonists.
Jonathon R Sawyer, Joseph A Audie, Jon Swanson, David Diller, Solimar Santiago, Victor J Hruby

Molecules· December 2024

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Ψ and χ Angle Constrains at the C-Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His-d-Phe-Arg-Trp-NH Lead to Potent and Selective Agonists at hMC1R and hMC4R.
Yang Zhou, Saghar Mowlazadeh Haghighi, Jonathon R Sawyer, Victor J Hruby, Minying Cai

J Med Chem· May 2023

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MC4R biased signalling and the conformational basis of biological function selections.
Zekun Liu, Victor J Hruby

J Cell Mol Med· August 2022

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CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists.
Stefano Tomassi, Marilisa Pia Dimmito, Minying Cai, Antonia D'Aniello, Alessandra Del Bene, Victor J Hruby

J Med Chem· March 2022

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C-terminal modified Enkephalin-like tetrapeptides with enhanced affinities at the kappa opioid receptor and monoamine transporters.
Mehr-Un-Nisa, Munawar A Munawar, David Rankin, Victor J Hruby, Frank Porreca

Bioorg Med Chem· December 2021

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Aged Brains Express Less Melanocortin Receptors, Which Correlates with Age-Related Decline of Cognitive Functions.
Yang Zhou, Monica K Chawla, Jose L Rios-Monterrosa, Lingzhi Wang, Marc A Zempare, Victor J Hruby

Molecules· October 2021

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Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism.
Yeon Sun Lee, Michael Remesic, Cyf Ramos-Colon, Zhijun Wu, Justin LaVigne, Victor J Hruby

Biomedicines· May 2021

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Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma.
Mikhail Kondrashov, Samuel P S Svensson, Peter Ström, Andreas Westermark, Hanna Jacobson-Ingemyr, Victor J Hruby

Bioconjug Chem· March 2021

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Development of Ligand-Drug Conjugates Targeting Melanoma through the Overexpressed Melanocortin 1 Receptor.
Yang Zhou, Saghar Mowlazadeh Haghighi, Zekun Liu, Lingzhi Wang, Victor J Hruby

ACS Pharmacol Transl Sci· October 2020

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Melanocortin 3 receptor activation with [D-Trp8]-γ-MSH suppresses inflammation in apolipoprotein E deficient mice.
James J Kadiri, Keshav Thapa, Katja Kaipio, Minying Cai, Victor J Hruby

Eur J Pharmacol· August 2020

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Toward a Universal μ-Agonist Template for Template-Based Alignment Modeling of Opioid Ligands.
Zhijun Wu, Victor J Hruby

ACS Omega· October 2019

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Development of -Acetylated Dipalmitoyl--Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists.
Yang Zhou, Abid H Banday, Victor J Hruby, Minying Cai

Molecules· September 2019

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Multivalent peptide and peptidomimetic ligands for the treatment of pain without toxicities and addiction.
Victor J Hruby

Peptides· June 2019

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Correction to Design of MC1R Selective γ-MSH Analogues with Canonical Amino Acids Leads to Potency and Pigmentation.
Yang Zhou, Saghar Mowlazadeh Haghighi, Ioanna Zoi, Jonathon R Sawyer, Victor J Hruby

J Med Chem· October 2018

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Synthesis and Evaluation of a Novel Bivalent Selective Antagonist for the Mu-Delta Opioid Receptor Heterodimer that Reduces Morphine Withdrawal in Mice.
Keith M Olson, Attila Keresztes, Jenna K Tashiro, Lisa V Daconta, Victor J Hruby

J Med Chem· July 2018

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Development of Macrocyclic Peptidomimetics Containing Constrained α,α-Dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors.
Francesco Merlino, Yang Zhou, Minying Cai, Alfonso Carotenuto, Ali M Yousif, Victor J Hruby

J Med Chem· May 2018

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Replacement of Arg with Nle and modified D-Phe in the core sequence of MSHs, Ac-His-D-Phe-Arg-Trp-NH, leads to hMC1R selectivity and pigmentation.
Saghar Mowlazadeh Haghighi, Yang Zhou, Jixun Dai, Jonathon R Sawyer, Victor J Hruby

Eur J Med Chem· May 2018

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Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.
Thomas Durek, Philipp M Cromm, Andrew M White, Christina I Schroeder, Quentin Kaas, Victor J Hruby

J Med Chem· April 2018

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Protection against β-amyloid neurotoxicity by a non-toxic endogenous N-terminal β-amyloid fragment and its active hexapeptide core sequence.
Kelly H Forest, Naghum Alfulaij, Komal Arora, Ruth Taketa, Tessi Sherrin, Victor J Hruby

J Neurochem· January 2018

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Design of MC1R Selective γ-MSH Analogues with Canonical Amino Acids Leads to Potency and Pigmentation.
Yang Zhou, Saghar Mowlazadeh Haghighi, Ioanna Zoi, Jonathon R Sawyer, Victor J Hruby

J Med Chem· November 2017

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Structural Insights into Selective Ligand-Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists.
Minying Cai, Udaya Kiran Marelli, Blake Mertz, Johannes G Beck, Florian Opperer, Victor J Hruby

Biochemistry· August 2017

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Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages.
Petteri Rinne, Martina Rami, Salla Nuutinen, Donato Santovito, Emiel P C van der Vorst, Victor J Hruby

Circulation· July 2017

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Recent Advances in the Realm of Allosteric Modulators for Opioid Receptors for Future Therapeutics.
Michael Remesic, Victor J Hruby, Frank Porreca, Yeon Sun Lee

ACS Chem Neurosci· June 2017

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Fluorescent-labeled bioconjugates of the opioid peptides biphalin and DPDPE incorporating fluorescein-maleimide linkers.
Azzurra Stefanucci, Wei Lei, Victor J Hruby, Giorgia Macedonio, Grazia Luisi

Future Med Chem· June 2017

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Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain.
Ruben S Vardanyan, James P Cain, Saghar Mowlazadeh Haghighi, Vlad K Kumirov, Mary I McIntosh, Victor J Hruby

J Heterocycl Chem· March 2017

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