Publications by authors named "Victor Tkachev"

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PTPN2-KO CAR-T Cells Demonstrate Enhanced Effector Function, CNS Infiltration, and Toxicity in a Non-Human Primate CAR-T Model.
Francesca Alvarez Calderon, Ryan A Fleming, Marlana Winschel, Lev Gorfinkel, Rebecca Sutherland, Victor Tkachev

bioRxiv· September 2025

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A single dose of a CD137 antibody-drug conjugate protects rhesus macaque allogeneic HCT recipients against acute GVHD.
Ulrike Gerdemann, Kyle Kimler, Matthew R Warren, Connor McGuckin, Ryan A Fleming, Victor Tkachev

Blood· August 2025

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Enhanced Costimulation Blockade With αCD154, αCD2, and αCD28 to Promote Heart Allograft Tolerance in Nonhuman Primates.
Ryan Chaban, Ikechukwu Ileka, Kohei Kinoshita, Gannon McGrath, Zahra Habibabady, Victor Tkachev

Transplantation· June 2025

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Precision Editing of Cyclophilin A Generates Cyclosporine and Voclosporin Resistant Cellular Therapies.
Holly Wobma, Francesca Alvarez Calderon, Jiayi Dong, Kayleigh Omdahl, Xianliang Rui, Victor Tkachev

bioRxiv· May 2025

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Prospective trial of the Oncobox platform RNA sequencing bioinformatic analysis for personalized prescription of targeted drugs.
Maksim Sorokin, Andrew Garazha, Maria Suntsova, Victor Tkachev, Elena Poddubskaya

Comput Biol Med· March 2025

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Organ-specific microenvironments drive divergent T cell evolution in acute graft-versus-host disease.
Kayleigh Ingersoll Omdahl, Rene S Bermea, Ryan Fleming, Kyle Kimler, James Kaminski, Victor Tkachev

Sci Transl Med· January 2025

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Bioinformatic and clinical experimental assay uncovers resistance and susceptibility mechanisms of human glioblastomas to temozolomide and identifies new combined and individual survival biomarkers outperforming promoter methylation.
Alexander Modestov, Marianna Zolotovskaia, Maria Suntsova, Galina Zakharova, Aleksander Seryakov, Victor Tkachev

Ther Adv Med Oncol· November 2024

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A New Approach of Detecting Fusion Oncogenes by RNA Sequencing Exon Coverage Analysis.
Galina Zakharova, Maria Suntsova, Elizaveta Rabushko, Tharaa Mohammad, Alexey Drobyshev, Victor Tkachev

Cancers (Basel)· November 2024

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Human OX40L-CAR-T target activated antigen-presenting cells and control T cell alloreactivity.
Xianliang Rui, Francesca Alvarez Calderon, Holly Wobma, Ulrike Gerdemann, Alexandre Albanese, Victor Tkachev

Sci Transl Med· October 2024

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Number of human protein interactions correlates with structural, but not regulatory conservation of the respective genes.
Rijalda Mekic, Marianna A Zolotovskaia, Maksim Sorokin, Tharaa Mohammad, Nina Shaban, Victor Tkachev

Front Genet· October 2024

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B-cell-directed CAR T-cell therapy activates CD8+ cytotoxic CARneg bystander T cells in patients and nonhuman primates.
James Kaminski, Ryan A Fleming, Francesca Alvarez-Calderon, Marlana B Winschel, Connor McGuckin, Victor Tkachev

Blood· July 2024

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Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate-conditioned Fanconi anemia mice.
Asim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J Riddle, Victor Tkachev

Blood· May 2024

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Pan-cancer experimental characteristic of human transcriptional patterns connected with telomerase reverse transcriptase () gene expression status.
Aleksey Drobyshev, Alexander Modestov, Maria Suntsova, Elena Poddubskaya, Alexander Seryakov, Victor Tkachev

Front Genet· May 2024

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DNA methylation and chromatin accessibility predict age in the domestic dog.
Kelly Jin, Brianah M McCoy, Elisabeth A Goldman, Viktoria Usova, Victor Tkachev

Aging Cell· April 2024

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Chronic GvHD NIH Consensus Project Biology Task Force: evolving path to personalized treatment of chronic GvHD.
Nataliya P Buxbaum, Gerard Socié, Geoffrey R Hill, Kelli P A MacDonald, Victor Tkachev

Blood Adv· September 2023

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Uniformly shaped harmonization combines human transcriptomic data from different platforms while retaining their biological properties and differential gene expression patterns.
Nicolas Borisov, Victor Tkachev, Alexander Simonov, Maxim Sorokin, Ella Kim

Front Mol Biosci· September 2023

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Large-scale assessment of pros and cons of autopsy-derived or tumor-matched tissues as the norms for gene expression analysis in cancers.
Maksim Sorokin, Anton A Buzdin, Anastasia Guryanova, Victor Efimov, Maria V Suntsova, Victor S Tkachev

Comput Struct Biotechnol J· August 2023

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Algorithmically Reconstructed Molecular Pathways as the New Generation of Prognostic Molecular Biomarkers in Human Solid Cancers.
Marianna Zolotovskaia, Maks Kovalenko, Polina Pugacheva, Victor Tkachev, Alexander Simonov

Proteomes· August 2023

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Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates.
Victor Tkachev, Ashley Vanderbeck, Eric Perkey, Scott N Furlan, Connor McGuckin

Sci Transl Med· June 2023

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Distinct Traits of Structural and Regulatory Evolutional Conservation of Human Genes with Specific Focus on Major Cancer Molecular Pathways.
Galina Zakharova, Alexander Modestov, Polina Pugacheva, Rijalda Mekic, Ekaterina Savina, Victor Tkachev

Cells· May 2023

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Engineering T cells to suppress acute GVHD and leukemia relapse after allogeneic hematopoietic stem cell transplantation.
Feiyan Mo, Norihiro Watanabe, Kayleigh I Omdahl, Phillip M Burkhardt, Xiaoyun Ding, Victor Tkachev

Blood· March 2023

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Pan-cancer antagonistic inhibition pattern of ATM-driven G2/M checkpoint pathway vs other DNA repair pathways.
Marianna A Zolotovskaia, Alexander A Modestov, Maria V Suntsova, Anastasia A Rachkova, Elena V Koroleva, Victor S Tkachev

DNA Repair (Amst)· March 2023

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Next-Generation Grade and Survival Expression Biomarkers of Human Gliomas Based on Algorithmically Reconstructed Molecular Pathways.
Marianna A Zolotovskaia, Max A Kovalenko, Victor S Tkachev, Alexander M Simonov, Maxim I Sorokin

Int J Mol Sci· June 2022

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OncoboxPD: human 51 672 molecular pathways database with tools for activity calculating and visualization.
Marianna A Zolotovskaia, Victor S Tkachev, Anastasia A Guryanova, Alexander M Simonov, Mikhail M Raevskiy

Comput Struct Biotechnol J· May 2022

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Better Agreement of Human Transcriptomic and Proteomic Cancer Expression Data at the Molecular Pathway Activation Level.
Mikhail Raevskiy, Maxim Sorokin, Galina Zakharova, Victor Tkachev, Nicolas Borisov

Int J Mol Sci· February 2022

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