Publications by authors named "Victor Uebele"

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Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator.
Michael T Rudd, Peter J Manley, Barbara Hanney, Zhaoyang Meng, Youheng Shu, Victor N Uebele

ACS Med Chem Lett· August 2023

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Discovery of 4-arylquinoline-2-carboxamides, highly potent and selective class of mGluR2 negative allosteric modulators: From HTS to activity in animal models.
Youheng Shu, Tracy L Diamond, James C Hershey, Shaei Huang, Brian C Magliaro, Victor N Uebele

Bioorg Med Chem Lett· May 2020

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Assessment of Clinical Activity of PD-1 Checkpoint Inhibitor Combination Therapies Reported in Clinical Trials.
Emmett V Schmidt, Michael J Chisamore, Marya F Chaney, Marie E Maradeo, James Anderson, Victor N Uebele

JAMA Netw Open· February 2020

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Dynamic Compound-Dependent Acoustic Transfer to Investigate Inhibitor Reversibility.
Jennifer Nothstein, Elisabeth MacColl, Paul Zuck, Jason Cassaday, Victor N Uebele

SLAS Technol· October 2017

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High-Throughput Agonist Shift Assay Development for the Analysis of M-Positive Allosteric Modulators.
Michelle F Homsher, Douglas C Beshore, Jason Cassaday, Brian Squadroni, Elizabeth Mohammed, Victor N Uebele

SLAS Discov· September 2017

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Prospective Assessment of Virtual Screening Heuristics Derived Using a Novel Fusion Score.
Dante A Pertusi, Gregory O'Donnell, Michelle F Homsher, Kelli Solly, Amita Patel, Victor N Uebele

SLAS Discov· September 2017

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Development of a Platform to Enable Fully Automated Cross-Titration Experiments.
Jason Cassaday, Michael Finley, Brian Squadroni, Sylvie Jezequel-Sur, Albert Rauch, Victor Uebele

SLAS Technol· April 2017

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Corrigendum to "Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects" [Bioorg. Med. Chem. Lett. 26 (2016) 5724-5728].
Matthew Lombardo, Kate Bender, Clare London, Michael A Plotkin, Melissa Kirkland, Victor N Uebele

Bioorg Med Chem Lett· March 2017

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Iterative Focused Screening with Biological Fingerprints Identifies Selective Asc-1 Inhibitors Distinct from Traditional High Throughput Screening.
Peter S Kutchukian, Lee Warren, Brian C Magliaro, Adam Amoss, Jason A Cassaday, Victor N Uebele

ACS Chem Biol· February 2017

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Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects.
Matthew Lombardo, Kate Bender, Clare London, Michael A Plotkin, Melissa Kirkland, Victor N Uebele

Bioorg Med Chem Lett· December 2016

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Identification and in Vivo Evaluation of Liver X Receptor β-Selective Agonists for the Potential Treatment of Alzheimer's Disease.
Shawn J Stachel, Celina Zerbinatti, Michael T Rudd, Mali Cosden, Sokreine Suon, Victor N Uebele

J Med Chem· April 2016

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Screening of HIV-1 Protease Using a Combination of an Ultra-High-Throughput Fluorescent-Based Assay and RapidFire Mass Spectrometry.
Juncai Meng, Ming-Tain Lai, Vandna Munshi, Jay Grobler, John McCauley, Victor N Uebele

J Biomol Screen· June 2015

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Use of high-throughput mass spectrometry to reduce false positives in protease uHTS screens.
Gregory C Adam, Juncai Meng, Joseph M Rizzo, Adam Amoss, Jeffrey W Lusen, Victor N Uebele

J Biomol Screen· February 2015

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Cross-modulation and molecular interaction at the Cav3.3 protein between the endogenous lipids and the T-type calcium channel antagonist TTA-A2.
Magali Cazade, Cindy E Nuss, Isabelle Bidaud, John J Renger, Victor N Uebele

Mol Pharmacol· February 2014

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Essential thalamic contribution to slow waves of natural sleep.
François David, Joscha T Schmiedt, Hannah L Taylor, Gergely Orban, Giuseppe Di Giovanni, Victor N Uebele

J Neurosci· December 2013

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Calcineurin signaling mediates activity-dependent relocation of the axon initial segment.
Mark D Evans, Rosanna P Sammons, Sabrina Lebron, Adna S Dumitrescu, Thomas B K Watkins, Victor N Uebele

J Neurosci· April 2013

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Hypothalamic neuropeptide S receptor blockade decreases discriminative cue-induced reinstatement of cocaine seeking in the rat.
Marsida Kallupi, Giordano de Guglielmo, Nazzareno Cannella, Hong Wu Li, Girolamo Caló, Victor N Uebele

Psychopharmacology (Berl)· March 2013

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Randomized controlled study of the T-type calcium channel antagonist MK-8998 for the treatment of acute psychosis in patients with schizophrenia.
Michael F Egan, Xin Zhao, Andrew Smith, Matthew D Troyer, Victor N Uebele

Hum Psychopharmacol· March 2013

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State-dependent properties of a new T-type calcium channel blocker enhance Ca(V)3.2 selectivity and support analgesic effects.
Amaury Francois, Nicolas Kerckhove, Mathieu Meleine, Abdelkrim Alloui, Christian Barrere, Victor N Uebele

Pain· February 2013

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Development of a fluorescence polarization binding assay for folate receptor.
Anna Y Kornilova, Bethany Algayer, Michael Breslin, George H Addona, Victor Uebele

Anal Biochem· January 2013

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Biphasic cholinergic synaptic transmission controls action potential activity in thalamic reticular nucleus neurons.
Yan-Gang Sun, Juan D Pita-Almenar, Chia-Shan Wu, John J Renger, Victor N Uebele

J Neurosci· January 2013

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Inhibition of T-type calcium current in rat thalamocortical neurons by isoflurane.
Veit-Simon Eckle, Michael R Digruccio, Victor N Uebele, John J Renger, Slobodan M Todorovic

Neuropharmacology· August 2012

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T-type calcium channels consolidate tonic action potential output of thalamic neurons to neocortex.
Charlotte Deleuze, François David, Sébastien Béhuret, Gérard Sadoc, Hee-Sup Shin, Victor N Uebele

J Neurosci· August 2012

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Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons.
Megan O Jacus, Victor N Uebele, John J Renger, Slobodan M Todorovic

J Neurosci· July 2012

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GABAergic synaptic transmission triggers action potentials in thalamic reticular nucleus neurons.
Yan-Gang Sun, Chia-Shan Wu, John J Renger, Victor N Uebele, Hui-Chen Lu

J Neurosci· June 2012

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