Publications by authors named "Vittal Shivva"

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A quantitative systems pharmacology model to inform clinical translation of dynamic PKPD relationships of engineered IL-15.
Louis R Joslyn, Mohammad Jafarnejad, Rajbharan Yadav, Patrick G Holder, Shomyseh Sanjabi, Vittal Shivva

Eur J Pharm Sci· November 2025

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Correction: Cellular Kinetics and Biodistribution of Adoptive T Cell Therapies: from Biological Principles to Effects on Patient Outcomes.
Ran Li, Abigail K Grosskopf, Louis R Joslyn, Eric Gary Stefanich, Vittal Shivva

AAPS J· July 2025

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Pharmacokinetics-Based Design of Subcutaneous Controlled Release Systems for Biologics.
Abigail K Grosskopf, Antonio A Ginart, Phillip Spinosa, Vittal Shivva

CPT Pharmacometrics Syst Pharmacol· April 2025

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Cellular Kinetics and Biodistribution of Adoptive T Cell Therapies: from Biological Principles to Effects on Patient Outcomes.
Ran Li, Abigail K Grosskopf, Louis R Joslyn, Eric Gary Stefanich, Vittal Shivva

AAPS J· March 2025

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Preclinical and translational pharmacology of afucosylated anti-CCR8 antibody for depletion of tumour-infiltrating regulatory T cells.
Gautham Gampa, Phillip Spinosa, Jennifer Getz, Yu Zhong, Wendy Halpern, Vittal Shivva

Br J Pharmacol· July 2024

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Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy.
Rajbharan Yadav, Suzanne Schubbert, Patrick G Holder, Eugene Y Chiang, Nargess Kiabi, Vittal Shivva

Front Pharmacol· June 2024

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Translatability of Stress for Predicting Deamidation and Oxidation Biotransformation on Biotherapeutics.
Phillip Y Chu, Hui Wang, Emily Ross, Nicole Stephens, Hui-Min Zhang, Vittal Shivva

Anal Chem· December 2023

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Complex PK-PD of an engineered IL-15/IL-15Rα-Fc fusion protein in cynomolgus monkeys: QSP modeling of lymphocyte dynamics.
Dan Lu, Rajbharan Yadav, Patrick Holder, Eugene Chiang, Shomyseh Sanjabi, Vittal Shivva

Eur J Pharm Sci· July 2023

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Direct Tie2 Agonists Stabilize Vasculature for the Treatment of Diabetic Macular Edema.
Nicholas J Agard, Gu Zhang, John Ridgeway, Danielle M Dicara, Phillip Y Chu, Vittal Shivva

Transl Vis Sci Technol· October 2022

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Evolution of preclinical characterization and insights into clinical pharmacology of checkpoint inhibitors approved for cancer immunotherapy.
Sreeneeranj Kasichayanula, Sandhya Mandlekar, Vittal Shivva, Maulik Patel, Sandhya Girish

Clin Transl Sci· August 2022

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Novel Anti-LY6G6D/CD3 T-Cell-Dependent Bispecific Antibody for the Treatment of Colorectal Cancer.
Peiyin Wang, Liping L Sun, Robyn Clark, Maria Hristopoulos, Cecilia P C Chiu, Vittal Shivva

Mol Cancer Ther· June 2022

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In Vivo Reoxidation Kinetics of Free Thiols in Multiple Domains of IgG1 Antibodies in Rats.
Michael T Kim, Martin Lechmann, Sharmila Rajan, Vittal Shivva, Aron Lee

J Pharm Sci· May 2021

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Antibody Format and Serum Disposition Govern Ocular Pharmacokinetics of Intravenously Administered Protein Therapeutics.
Vittal Shivva, C Andrew Boswell, Hanine Rafidi, Robert F Kelley, Amrita V Kamath

Front Pharmacol· May 2021

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Improving priors for human monoclonal antibody linear pharmacokinetic parameters by using half-lives from non-human primates.
Vittal Shivva, Martin Fink, Philip J Lowe

J Pharmacokinet Pharmacodyn· April 2021

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An In Silico Knockout Model for Gastrointestinal Absorption Using a Systems Pharmacology Approach - Development and Application for Ketones.
Vittal Shivva, Ian G Tucker, Stephen B Duffull

PLoS One· September 2016

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The Population Pharmacokinetics of D-β-hydroxybutyrate Following Administration of (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate.
Vittal Shivva, Pete J Cox, Kieran Clarke, Richard L Veech, Ian G Tucker

AAPS J· May 2016

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Parameterisation affects identifiability of population models.
Vittal Shivva, Julia Korell, Ian G Tucker, Stephen B Duffull

J Pharmacokinet Pharmacodyn· February 2014

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Species difference in the in vitro and in vivo metabolism of amtolmetin guacil.
Kishore Kumar Hotha, Vijaya Bharathi Dasari, Abdul Naveed Shaik, Muzeeb Syed, Vittal Shivva

Arzneimittelforschung· January 2011

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Highly sensitive method for the determination of omeprazole in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry: application to a clinical pharmacokinetic study.
Shivva Vittal, Ramesh Ganneboina, Buddhadev Layek, Ravi Kumar Trivedi, Kishore Kumar Hotha

Biomed Chromatogr· April 2009

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Chiral bioanalysis of torcetrapib enantiomers in hamster plasma by normal-phase liquid chromatography and detection by atmospheric pressure chemical ionization tandem mass spectrometry.
Ravi Kumar Trivedi, Buddhadev Layek, T Santosh Kumar, Shivva Vittal, Ramesh Ganneboina

J Chromatogr B Analyt Technol Biomed Life Sci· December 2007

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Simultaneous quantitation of rosuvastatin and gemfibrozil in human plasma by high-performance liquid chromatography and its application to a pharmacokinetic study.
Shivva Vittal, Nikhil R Shitut, Thammera Ranjit Kumar, Menon C A Vinu, Ramesh Mullangi

Biomed Chromatogr· November 2006

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