Publications by authors named "Patrick Holder"

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A quantitative systems pharmacology model to inform clinical translation of dynamic PKPD relationships of engineered IL-15.
Louis R Joslyn, Mohammad Jafarnejad, Rajbharan Yadav, Patrick G Holder, Shomyseh Sanjabi

Eur J Pharm Sci· November 2025

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IL-15/IL-15Rα-Fc-Fusion Protein XmAb24306 Potentiates Activity of CD3 Bispecific Antibodies through Enhancing T-Cell Expansion.
Ji Li, Robyn Clark, Dionysos Slaga, Kendra Avery, Ke Liu, Patrick G Holder

Mol Cancer Ther· September 2024

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Bioproduction Platform to Generate Functionalized Disulfide-Constrained Peptide Analogues.
Sunhee Hwang, Aaron T Balana, Bryan Martin, Michael Clarkson, Paola Di Lello, Patrick Holder

ACS Bio Med Chem Au· August 2024

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Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy.
Rajbharan Yadav, Suzanne Schubbert, Patrick G Holder, Eugene Y Chiang, Nargess Kiabi

Front Pharmacol· June 2024

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Adapting Ferritin, a Naturally Occurring Protein Cage, to Modulate Intrinsic Agonism of OX40.
Whitney Shatz-Binder, Caleigh M Azumaya, Brandon Leonard, Ivan Vuong, Jawahar Sudhamsu, Patrick G Holder

Bioconjug Chem· May 2024

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Efbalropendekin Alfa enhances human natural killer cell cytotoxicity against tumor cell lines .
Hesham M Shehata, Pranay Dogra, Sarah Gierke, Patrick Holder, Shomyseh Sanjabi

Front Immunol· March 2024

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Translatability of Stress for Predicting Deamidation and Oxidation Biotransformation on Biotherapeutics.
Phillip Y Chu, Hui Wang, Emily Ross, Nicole Stephens, Hui-Min Zhang, Patrick G Holder

Anal Chem· December 2023

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Complex PK-PD of an engineered IL-15/IL-15Rα-Fc fusion protein in cynomolgus monkeys: QSP modeling of lymphocyte dynamics.
Dan Lu, Rajbharan Yadav, Patrick Holder, Eugene Chiang, Shomyseh Sanjabi

Eur J Pharm Sci· July 2023

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Comprehensive UHPLC- and CE-based methods for engineered Cas9 characterization.
Julien Camperi, Gary Console, Laura Zheng, Nicole Stephens, Mary Montti, Patrick Holder

Talanta· January 2023

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Generation of a Porcine Antibody Fab Fragment Using Protein Engineering to Facilitate the Evaluation of Ocular Sustained Delivery Technology.
Robert F Kelley, Devin B Tesar, Yue Wang, Nicholas J Agard, Patrick G Holder

Mol Pharm· May 2022

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Engineering interferons and interleukins for cancer immunotherapy.
Patrick G Holder, Shion A Lim, Christine S Huang, Preeti Sharma, Yavuz S Dagdas

Adv Drug Deliv Rev· March 2022

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DNA-Model-Based Design and Execution of Some Fused Benzodiazepine Hybrid Payloads for Antibody-Drug Conjugate Modality.
Prasanna Sivaprakasam, Ivar McDonald, Christiana Iwuagwu, Naidu S Chowdari, Kevin M Peese, Patrick Holder

ACS Med Chem Lett· March 2021

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High-Throughput Platform to Identify Antibody Conjugation Sites from Antibody-Drug Conjugate Libraries.
Sayumi Yamazoe, Jason M Hogan, Sean M West, Xiaodi A Deng, Srikanth Kotapati, Patrick Holder

Bioconjug Chem· April 2020

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Solving the kidney shortage via the creation of kidney donation co-operatives.
K C Eames, Patrick Holder, Eduardo Zambrano

J Health Econ· July 2017

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Generating aldehyde-tagged antibodies with high titers and high formylglycine yields by supplementing culture media with copper(II).
Dona York, Jeanne Baker, Patrick G Holder, Lesley C Jones, Penelope M Drake

BMC Biotechnol· February 2016

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Direct Interfacial Y Oxidation in α by a Photoβ Subunit of Class Ia Ribonucleotide Reductase.
David Y Song, Arturo A Pizano, Patrick G Holder, JoAnne Stubbe, Daniel G Nocera

Chem Sci· August 2015

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Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion.
Patrick G Holder, Lesley C Jones, Penelope M Drake, Robyn M Barfield, Stefanie Bañas

J Biol Chem· June 2015

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Generating site-specifically modified proteins via a versatile and stable nucleophilic carbon ligation.
Romas Kudirka, Robyn M Barfield, Jesse McFarland, Aaron E Albers, Gregory W de Hart, Patrick G Holder

Chem Biol· February 2015

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Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes.
Penelope M Drake, Aaron E Albers, Jeanne Baker, Stefanie Banas, Robyn M Barfield, Patrick Holder

Bioconjug Chem· July 2014

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Modulation of Y356 photooxidation in E. coli class Ia ribonucleotide reductase by Y731 across the α2:β2 interface.
Arturo A Pizano, Lisa Olshansky, Patrick G Holder, Joanne Stubbe, Daniel G Nocera

J Am Chem Soc· September 2013

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Deciphering radical transport in the large subunit of class I ribonucleotide reductase.
Patrick G Holder, Arturo A Pizano, Bryce L Anderson, Joanne Stubbe, Daniel G Nocera

J Am Chem Soc· January 2012

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Photo-ribonucleotide reductase β2 by selective cysteine labeling with a radical phototrigger.
Arturo A Pizano, Daniel A Lutterman, Patrick G Holder, Thomas S Teets, JoAnne Stubbe

Proc Natl Acad Sci U S A· January 2012

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Dramatic thermal stability of virus-polymer conjugates in hydrophobic solvents.
Patrick G Holder, Daniel T Finley, Nicholas Stephanopoulos, Ross Walton, Douglas S Clark

Langmuir· November 2010

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Dual-surface-modified bacteriophage MS2 as an ideal scaffold for a viral capsid-based drug delivery system.
Ernest W Kovacs, Jacob M Hooker, Dante W Romanini, Patrick G Holder, Katherine E Berry

Bioconjug Chem· October 2007

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Integration of a self-assembling protein scaffold with water-soluble single-walled carbon nanotubes.
Patrick G Holder, Matthew B Francis

Angew Chem Int Ed Engl· September 2007

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