Publications by authors named "Wayne Blosser"

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RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies.
Benjamin J Solomon, Lavinia Tan, Jessica J Lin, Stephen Q Wong, Sebastian Hollizeck, Wayne Blosser

J Thorac Oncol· April 2020

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A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib.
Wayne D Blosser, Jack A Dempsey, Ann M McNulty, Xi Rao, Philip J Ebert

Oncotarget· January 2020

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Anti-VEGFR2 therapy delays growth of preclinical pediatric tumor models and enhances anti-tumor activity of chemotherapy.
Caitlin D Lowery, Wayne Blosser, Michele Dowless, Matthew Renschler, Lisa V Perez

Oncotarget· September 2019

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Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models.
Caitlin D Lowery, Michele Dowless, Matthew Renschler, Wayne Blosser, Alle B VanWye

Clin Cancer Res· April 2019

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Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the Tumor Suppressor Gene.
Xueqian Gong, Jian Du, Stephen H Parsons, Farhana F Merzoug, Yue Webster, Wayne Blosser

Cancer Discov· February 2019

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Abemaciclib Is Active in Preclinical Models of Ewing Sarcoma via Multipronged Regulation of Cell Cycle, DNA Methylation, and Interferon Pathway Signaling.
Michele Dowless, Caitlin D Lowery, Terry Shackleford, Matthew Renschler, Jennifer Stephens, Wayne Blosser

Clin Cancer Res· December 2018

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Olaratumab Exerts Antitumor Activity in Preclinical Models of Pediatric Bone and Soft Tissue Tumors through Inhibition of Platelet-Derived Growth Factor Receptor α.
Caitlin D Lowery, Wayne Blosser, Michele Dowless, Shelby Knoche, Jennifer Stephens

Clin Cancer Res· February 2018

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The Checkpoint Kinase 1 Inhibitor Prexasertib Induces Regression of Preclinical Models of Human Neuroblastoma.
Caitlin D Lowery, Alle B VanWye, Michele Dowless, Wayne Blosser, Beverly L Falcon

Clin Cancer Res· August 2017

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LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer.
Eliza Vakana, Susan Pratt, Wayne Blosser, Michele Dowless, Nicholas Simpson

Oncotarget· February 2017

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A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology.
Courtney M Tate, Jacquelyn Mc Entire, Roberto Pallini, Eliza Vakana, Lisa Wyss, Wayne Blosser

PLoS One· April 2016

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LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms.
Constance King, H Bruce Diaz, Samuel McNeely, Darlene Barnard, Jack Dempsey, Wayne Blosser

Mol Cancer Ther· September 2015

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A method to assess target gene involvement in angiogenesis in vitro and in vivo using lentiviral vectors expressing shRNA.
Wayne Blosser, Eliza Vakana, Lisa V Wyss, Michelle L Swearingen, Julie Stewart

PLoS One· June 2015

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Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor.
Constance King, Henry Diaz, Darlene Barnard, David Barda, David Clawson, Wayne Blosser

Invest New Drugs· April 2014

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LY2228820 dimesylate, a selective inhibitor of p38 mitogen-activated protein kinase, reduces angiogenic endothelial cord formation in vitro and in vivo.
Courtney M Tate, Wayne Blosser, Lisa Wyss, Glenn Evans, Qi Xue

J Biol Chem· March 2013

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Knockdown of ubiquitin ligases in glioblastoma cancer stem cells leads to cell death and differentiation.
Jonathan Low, Wayne Blosser, Michele Dowless, Lucia Ricci-Vitiani, Roberto Pallini

J Biomol Screen· February 2012

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Tasisulam sodium, an antitumor agent that inhibits mitotic progression and induces vascular normalization.
Timothy Meier, Mark Uhlik, Sudhakar Chintharlapalli, Michele Dowless, Robert Van Horn, Wayne Blosser

Mol Cancer Ther· November 2011

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A robust high-content imaging approach for probing the mechanism of action and phenotypic outcomes of cell-cycle modulators.
Jeffrey J Sutherland, Jonathan Low, Wayne Blosser, Michele Dowless, Thomas A Engler

Mol Cancer Ther· February 2011

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Phenotypic fingerprinting of small molecule cell cycle kinase inhibitors for drug discovery.
Jonathan Low, Arunava Chakravartty, Wayne Blosser, Michele Dowless, Christopher Chalfant

Curr Chem Genomics· March 2009

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High-content imaging characterization of cell cycle therapeutics through in vitro and in vivo subpopulation analysis.
Jonathan Low, Shuguang Huang, Wayne Blosser, Michele Dowless, John Burch

Mol Cancer Ther· August 2008

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High-content imaging analysis of the knockdown effects of validated siRNAs and antisense oligonucleotides.
Jonathan Low, Shuguang Huang, Michele Dowless, Wayne Blosser, Thomas Vincent

J Biomol Screen· September 2007

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