Publications by authors named "Weei-Chin Lin"

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Mutant p53 variants differentially impact replication initiation and activate cGAS-STING to affect immune checkpoint inhibition.
Kang Liu, Lidija A Wilhelms Garan, Fang-Tsyr Lin, Weei-Chin Lin

Commun Biol· November 2025

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A novel prediction model of the risk of pancreatic cancer among diabetes patients using multiple clinical data and machine learning.
Shih-Min Chen, Phan Thanh Phuc, Phung-Anh Nguyen, Whitney Burton, Shwu-Jiuan Lin, Weei-Chin Lin

Cancer Med· October 2023

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DNA2 Nuclease Inhibition Confers Synthetic Lethality in Cancers with Mutant p53 and Synergizes with PARP Inhibitors.
Helena Folly-Kossi, Joshua D Graves, Lidija A Wilhelms Garan, Fang-Tsyr Lin, Weei-Chin Lin

Cancer Res Commun· October 2023

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A small-molecule inhibitor of TopBP1 exerts anti-MYC activity and synergy with PARP inhibitors.
Fang-Tsyr Lin, Kang Liu, Lidija A Wilhelms Garan, Helena Folly-Kossi, Yongcheng Song, Shwu-Jiuan Lin, Weei-Chin Lin

Proc Natl Acad Sci U S A· October 2023

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Super-enhanced MARCO variant drives triple-negative breast cancer progression.
Weei-Chin Lin, Fang-Tsyr Lin

Proc Natl Acad Sci U S A· December 2022

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14-3-3τ drives estrogen receptor loss via ERα36 induction and GATA3 inhibition in breast cancer.
Lidija A Wilhelms Garan, Yang Xiao, Weei-Chin Lin

Proc Natl Acad Sci U S A· October 2022

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Associations of Warfarin Use with Risks of Ischemic Cerebrovascular Events and Major Bleeding in Patients with Hyperthyroidism-Related Atrial Fibrillation.
Sian-De Liu, Shwu-Jiuan Lin, Chin-Ying Ray, Fang-Tsyr Lin, Weei-Chin Lin

Biomedicines· October 2022

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Effectiveness and Safety of Immunosuppressants and Biological Therapy for Chronic Spontaneous Urticaria: A Network Meta-Analysis.
Wen-Kuang Lin, Shwu-Jiuan Lin, Woan-Ruoh Lee, Chia-Chieh Lin, Weei-Chin Lin

Biomedicines· September 2022

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RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis.
Shiuh-Rong Ho, Yu-Cheng Lee, Michael M Ittmann, Fang-Tsyr Lin, Keith Syson Chan, Weei-Chin Lin

Cancer Lett· November 2021

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Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancer.
Kang Liu, Joshua D Graves, Fang-Tsyr Lin, Weei-Chin Lin

J Biol Chem· August 2021

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Correction: Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancer.
Kang Liu, Joshua D Graves, Fang-Tsyr Lin, Weei-Chin Lin

J Biol Chem· July 2021

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ACTL6A promotes repair of cisplatin-induced DNA damage, a new mechanism of platinum resistance in cancer.
Yang Xiao, Fang-Tsyr Lin, Weei-Chin Lin

Proc Natl Acad Sci U S A· January 2021

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Central nervous system intravascular lymphoma leading to rapidly progressive dementia.
Christie G Turin, Kevin Ting, Anthony Bradshaw, S Richard Dunham, Karen Nunez-Wallace, Weei-Chin Lin

Proc (Bayl Univ Med Cent)· January 2021

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E2F1 sumoylation as a protective cellular mechanism in oxidative stress response.
Joshua D Graves, Yu-Ju Lee, Kang Liu, Gang Li, Fang-Tsyr Lin, Weei-Chin Lin

Proc Natl Acad Sci U S A· June 2020

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Cell Cycle-Dependent Switch of TopBP1 Functions by Cdk2 and Akt.
Kang Liu, Joshua D Graves, Yu-Ju Lee, Fang-Tsyr Lin, Weei-Chin Lin

Mol Cell Biol· March 2020

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CGRRF1, a growth suppressor, regulates EGFR ubiquitination in breast cancer.
Yu-Ju Lee, Shiuh-Rong Ho, Joshua D Graves, Yang Xiao, Shixia Huang, Weei-Chin Lin

Breast Cancer Res· December 2019

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RNF144A sustains EGFR signaling to promote EGF-dependent cell proliferation.
Shiuh-Rong Ho, Weei-Chin Lin

J Biol Chem· October 2018

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Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.
Kang Liu, Fang-Tsyr Lin, Joshua D Graves, Yu-Ju Lee, Weei-Chin Lin

Proc Natl Acad Sci U S A· May 2017

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TRIP6 antagonizes the recruitment of A20 and CYLD to TRAF6 to promote the LPA2 receptor-mediated TRAF6 activation.
Fang-Tsyr Lin, Vivian Y Lin, Victor Tg Lin, Weei-Chin Lin

Cell Discov· March 2016

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Regulation of E2 promoter binding factor 1 (E2F1) transcriptional activity through a deubiquitinating enzyme, UCH37.
Christina S Mahanic, Varija Budhavarapu, Joshua D Graves, Gang Li, Weei-Chin Lin

J Biol Chem· October 2015

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Regulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane Domain.
Shiuh-Rong Ho, Yu-Ju Lee, Weei-Chin Lin

J Biol Chem· September 2015

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Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy.
Pinki Chowdhury, Gregory E Lin, Kang Liu, Yongcheng Song, Fang-Tsyr Lin, Weei-Chin Lin

Nat Commun· November 2014

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14-3-3τ promotes breast cancer invasion and metastasis by inhibiting RhoGDIα.
Yang Xiao, Vivian Y Lin, Shi Ke, Gregory E Lin, Fang-Tsyr Lin, Weei-Chin Lin

Mol Cell Biol· July 2014

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RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage.
Shiuh-Rong Ho, Christina S Mahanic, Yu-Ju Lee, Weei-Chin Lin

Proc Natl Acad Sci U S A· July 2014

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Akt switches TopBP1 function from checkpoint activation to transcriptional regulation through phosphoserine binding-mediated oligomerization.
Kang Liu, Joshua D Graves, Jessica D Scott, Rongbao Li, Weei-Chin Lin

Mol Cell Biol· December 2013

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