Publications by authors named "Wenchen Pu"

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Discovery of a Novel G9a-Selective Inhibitor for Hepatocellular Carcinoma Treatment.
Xiaoyu Mu, Jiao Li, Rong Wei, Jian-Kang Zhou, Yue Ming, Wenchen Pu

ACS Med Chem Lett· November 2025

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Antibody-based targeted protein degradation for membrane and extracellular proteins: emerging strategies and breakthroughs.
Rong Wei, Wenchen Pu, Yong Peng

Sci China Life Sci· October 2025

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Structure-directing optimization of N-(2,3-dihydrobenzo[b] [1,4]dioxin-6-yl)benzamide derivatives as selective receptor tyrosine kinase-like orphan receptor 1 (ROR1) inhibitors for cancer therapy.
Qingquan Zheng, Hulin Ma, Dongdong Luo, Xingyang Qiu, Yue Ming, Wenchen Pu

Eur J Med Chem· September 2025

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Optimization of 1-Methyl-3-(pyridin-3-yl)-1-indol Derivatives as ROR1 Inhibitors with Improved Activity and Selectivity.
Qingquan Zheng, Xingyang Qiu, Dongdong Luo, Hulin Ma, Yue Ming, Wenchen Pu

J Med Chem· June 2025

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Structure-Guided Optimization and Preclinical Evaluation of 6--Benzylguanine-Based Pin1 Inhibitor for Hepatocellular Carcinoma Treatment.
Wenchen Pu, Xianyan Shen, Xin Fan, Yuanyuan Zheng, Xuesha Liu

J Med Chem· February 2025

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Rational Design, Synthesis, and Biological Evaluation of Novel c-Met Degraders for Lung Cancer Therapy.
Xingyang Qiu, Qingquan Zheng, Dongdong Luo, Yue Ming, Tingting Zhang, Wenchen Pu

J Med Chem· February 2025

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Targeting oncogenic transcriptional factor c-myc by oligonucleotide PROTAC for the treatment of hepatocellular carcinoma.
Min Ai, Hulin Ma, Jianhua He, Fuyan Xu, Yue Ming, Wenchen Pu

Eur J Med Chem· December 2024

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Small-molecule-based targeted therapy in liver cancer.
Yue Ming, Yanqiu Gong, Xuewen Fu, Xinyu Ouyang, Yong Peng, Wenchen Pu

Mol Ther· October 2024

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Penfluridol inhibits melanoma growth and metastasis through enhancing von Hippel‒Lindau tumor suppressor-mediated cancerous inhibitor of protein phosphatase 2A (CIP2A) degradation.
Fuyan Xu, Jiao Li, Min Ai, Tingting Zhang, Yue Ming, Wenchen Pu

MedComm (2020)· October 2024

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Copper-Catalyzed Intramolecular Decarboxylative C(sp2)-Heteroatom Cross-Couplings: Mechanism Insights and Synthetic Applications.
Wenchen Pu, Shunli Wan, Qiang Zhou, Yanqiu Gong, Xuewen Fu

J Org Chem· September 2024

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The tumor-intrinsic role of the mA reader YTHDF2 in regulating immune evasion.
Sai Xiao, Shoubao Ma, Baofa Sun, Wenchen Pu, Songqi Duan

Sci Immunol· May 2024

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Exosomes rewire the cartilage microenvironment in osteoarthritis: from intercellular communication to therapeutic strategies.
Yuangang Wu, Jiao Li, Yi Zeng, Wenchen Pu, Xiaoyu Mu

Int J Oral Sci· August 2022

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Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2.
Xiuxiu Jin, Li Li, Qinlu Peng, Chunmei Gan, Li Gao, Wenchen Pu

iScience· May 2022

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PHLDB2 Mediates Cetuximab Resistance via Interacting With EGFR in Latent Metastasis of Colorectal Cancer.
Maochao Luo, Zhao Huang, Xingyue Yang, Yan Chen, Jingwen Jiang, Wenchen Pu

Cell Mol Gastroenterol Hepatol· April 2022

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Proteolysis-targeting chimeras (PROTACs) in cancer therapy.
Xinyi Li, Wenchen Pu, Qingquan Zheng, Min Ai, Song Chen

Mol Cancer· April 2022

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Three new 3-formyl-2-arylbenzofurans from and their anti-hepatocellular carcinoma effects.
Tian-Qiong Lang, Guo-Yong Luo, Wen-Chen Pu, Zhi-Wei Wang, Jian Wang

Nat Prod Res· March 2022

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Microtubule affinity regulating kinase 4 promoted activation of the NLRP3 inflammasome-mediated pyroptosis in periodontitis.
Lulu Wang, Wenchen Pu, Chun Wang, Lang Lei, Houxuan Li

J Oral Microbiol· December 2021

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Therapeutic targeting of RNA-binding protein by RNA-PROTAC.
Xinyi Li, Wenchen Pu, Song Chen, Yong Peng

Mol Ther· June 2021

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Cysteine-113 covalency inspires the development of Pin1 inhibitor.
Wenchen Pu, Jiao Li, Yong Peng

Signal Transduct Target Ther· October 2020

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MicroRNA Biogenesis is Enhanced by Liposome-Encapsulated Pin1 Inhibitor in Hepatocellular Carcinoma.
Dan Sun, Shuangyan Tan, Yanli Xiong, Wenchen Pu, Jiao Li

Theranostics· August 2020

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PDLIM1 Inhibits Tumor Metastasis Through Activating Hippo Signaling in Hepatocellular Carcinoma.
Zhao Huang, Jian-Kang Zhou, Kui Wang, Haining Chen, Siyuan Qin, Wenchen Pu

Hepatology· May 2020

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Circular RNAs in Cancer: Biogenesis, Function, and Clinical Significance.
Jiao Li, Dan Sun, Wenchen Pu, Jin Wang, Yong Peng

Trends Cancer· April 2020

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Prolyl Isomerase Pin1 in Human Cancer: Function, Mechanism, and Significance.
Wenchen Pu, Yuanyuan Zheng, Yong Peng

Front Cell Dev Biol· March 2020

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An Unbiased Immunoaffinity-Based Strategy for Profiling Covalent Drug Targets In Vivo.
Xinyuan Wang, Xiuxuan Wang, Xinghua Pu, Wenchen Pu, Yuqi Wang

Anal Chem· December 2019

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Discovery of Coumarin as Microtubule Affinity-Regulating Kinase 4 Inhibitor That Sensitize Hepatocellular Carcinoma to Paclitaxel.
Xianyan Shen, Xuesha Liu, Shunli Wan, Xin Fan, Huaiyu He, Wenchen Pu

Front Chem· May 2019

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