Publications by authors named "Wendy Offen"

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Signal-strapping as a protein-sequence search method for the discovery of metalloproteins.
João Paulo L Franco Cairo, Thamy L R Corrêa, Wendy A Offen, Alison K Nairn, Julia Walton

Nat Commun· October 2025

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Bespoke Activity-Based Probes Reveal that the Endoglycosidase, PslG, Is an Endo-β-glucanase.
Gijs Ruijgrok, Wendy A Offen, Isabelle B Pickles, Deepa Raju, Thanasis Patsos

J Am Chem Soc· March 2025

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Selective labelling of GBA2 in cells with fluorescent β-d-arabinofuranosyl cyclitol aziridines.
Qin Su, Max Louwerse, Rob F Lammers, Elmer Maurits, Max Janssen, Wendy A Offen

Chem Sci· September 2024

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β-l-furano-cyclitol Aziridines Are Covalent Broad-Spectrum Inhibitors and Activity-Based Probes for Retaining β-l-Arabinofuranosidases.
Valentina Borlandelli, Wendy Offen, Olga Moroz, Alba Nin-Hill, Nicholas McGregor

ACS Chem Biol· December 2023

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A Multiplexing Activity-Based Protein-Profiling Platform for Dissection of a Native Bacterial Xyloglucan-Degrading System.
Nicholas G S McGregor, Casper de Boer, Quentin P O Foucart, Thomas Beenakker, Wendy A Offen

ACS Cent Sci· December 2023

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The development of a broad-spectrum retaining β-exo-galactosidase activity-based probe.
Chi-Lin Kuo, Qin Su, Adrianus M C H van den Nieuwendijk, Thomas J M Beenakker, Wendy A Offen

Org Biomol Chem· October 2023

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Synthesis of broad-specificity activity-based probes for -β-mannosidases.
Nicholas G S McGregor, Chi-Lin Kuo, Thomas J M Beenakker, Chun-Sing Wong, Wendy A Offen

Org Biomol Chem· January 2022

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Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents.
Rhianna J Rowland, Yurong Chen, Imogen Breen, Liang Wu, Wendy A Offen

Chemistry· November 2021

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Development of Non-Hydrolysable Oligosaccharide Activity-Based Inactivators for Endoglycanases: A Case Study on α-1,6 Mannanases.
Sybrin P Schröder, Wendy A Offen, Alexandra Males, Yi Jin, Casper de Boer

Chemistry· July 2021

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Profiling Substrate Promiscuity of Wild-Type Sugar Kinases for Multi-fluorinated Monosaccharides.
Tessa Keenan, Fabio Parmeggiani, Julien Malassis, Clement Q Fontenelle, Jean-Baptiste Vendeville, Wendy Offen

Cell Chem Biol· September 2020

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Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and -5a-Substituted Derivatives of 4--Isofagomine.
Patrick Weber, Martin Thonhofer, Summer Averill, Gideon J Davies, Andres Gonzalez Santana, Wendy A Offen

Molecules· September 2020

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Correction: Synthesis and application of a highly branched, mechanism-based 2-deoxy-2-fluoro-oligosaccharide inhibitor of endo-xyloglucanases.
Namrata Jain, Mohamed A Attia, Wendy A Offen, Gideon J Davies, Harry Brumer

Org Biomol Chem· January 2019

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Functional and informatics analysis enables glycosyltransferase activity prediction.
Min Yang, Charlie Fehl, Karen V Lees, Eng-Kiat Lim, Wendy A Offen

Nat Chem Biol· December 2018

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Synthesis and application of a highly branched, mechanism-based 2-deoxy-2-fluoro-oligosaccharide inhibitor of endo-xyloglucanases.
Namrata Jain, Mohamed A Attia, Wendy A Offen, Gideon J Davies, Harry Brumer

Org Biomol Chem· November 2018

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Gluco-1 H-imidazole: A New Class of Azole-Type β-Glucosidase Inhibitor.
Sybrin P Schröder, Liang Wu, Marta Artola, Thomas Hansen, Wendy A Offen

J Am Chem Soc· April 2018

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In vitro and in vivo characterization of three glycoside hydrolase family 5 members reveals potent xyloglucan backbone-cleaving functions.
Mohamed A Attia, Cassandra E Nelson, Wendy A Offen, Namrata Jain, Gideon J Davies

Biotechnol Biofuels· February 2018

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Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines.
Sybrin P Schröder, Jasper W van de Sande, Wouter W Kallemeijn, Chi-Lin Kuo, Marta Artola, Wendy A Offen

Chem Commun (Camb)· November 2017

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1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor.
Marta Artola, Liang Wu, Maria J Ferraz, Chi-Lin Kuo, Lluís Raich, Wendy A Offen

ACS Cent Sci· July 2017

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Structural and functional insight into human O-GlcNAcase.
Christian Roth, Sherry Chan, Wendy A Offen, Glyn R Hemsworth, Lianne I Willems

Nat Chem Biol· June 2017

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Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors.
Thomas J M Beenakker, Dennis P A Wander, Wendy A Offen, Marta Artola, Lluís Raich

J Am Chem Soc· May 2017

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Three-dimensional structures of two heavily N-glycosylated Aspergillus sp. family GH3 β-D-glucosidases.
Jon Agirre, Antonio Ariza, Wendy A Offen, Johan P Turkenburg, Shirley M Roberts

Acta Crystallogr D Struct Biol· February 2016

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Three-dimensional structure of a variant `Termamyl-like' Geobacillus stearothermophilus α-amylase at 1.9 Å resolution.
Wendy A Offen, Anders Viksoe-Nielsen, Torben V Borchert, Keith S Wilson, Gideon J Davies

Acta Crystallogr F Struct Biol Commun· January 2015

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Structure and activity of the Streptomyces coelicolor A3(2) β-N-acetylhexosaminidase provides further insight into GH20 family catalysis and inhibition.
Nhung Nguyen Thi, Wendy A Offen, François Shareck, Gideon J Davies, Nicolas Doucet

Biochemistry· March 2014

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Structural enzymology of Helicobacter pylori methylthioadenosine nucleosidase in the futalosine pathway.
Robbert Q Kim, Wendy A Offen, Gideon J Davies, Keith A Stubbs

Acta Crystallogr D Biol Crystallogr· January 2014

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Structure and activity of Paenibacillus polymyxa xyloglucanase from glycoside hydrolase family 44.
Antonio Ariza, Jens M Eklöf, Oliver Spadiut, Wendy A Offen, Shirley M Roberts

J Biol Chem· September 2011

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