Publications by authors named "Wendy Shoop"

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Transient muscle expression of mitoARCUS in mice leads to a sustained reduction in pathogenic mtDNA content and improves muscle function.
Sandra R Bacman, Wendy Shoop, C Spencer Henley-Beasley, Rhese Thompson, Jose Domingo Barrera-Paez

Mol Ther· December 2025

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Efficient elimination of MELAS-associated m.3243G mutant mitochondrial DNA by an engineered mitoARCUS nuclease.
Wendy K Shoop, Janel Lape, Megan Trum, Alea Powell, Emma Sevigny

Nat Metab· December 2023

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Precise and simultaneous quantification of mitochondrial DNA heteroplasmy and copy number by digital PCR.
Wendy K Shoop, Cassandra L Gorsuch, Sandra R Bacman, Carlos T Moraes

J Biol Chem· November 2022

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Treating Transthyretin Amyloidosis via Adeno-Associated Virus Vector Delivery of Meganucleases.
Jenny A Greig, Camilo Breton, Scott N Ashley, Kelly M Martins, Cassandra Gorsuch, Wendy Shoop

Hum Gene Ther· November 2022

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Targeting the hepatitis B cccDNA with a sequence-specific ARCUS nuclease to eliminate hepatitis B virus in vivo.
Cassandra L Gorsuch, Paige Nemec, Mei Yu, Simin Xu, Dong Han, Wendy Shoop

Mol Ther· September 2022

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Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo.
Ugne Zekonyte, Sandra R Bacman, Jeff Smith, Wendy Shoop, Claudia V Pereira

Nat Commun· May 2021

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