Publications by authors named "Wenwei You"

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Structure-Guided Discovery of Novel -(Substituted Thiazol-2-yl)--(4-Substituted phenyl)pyrimidine-2,4-Diamines as Potent CDK2 and CDK9 Dual Inhibitors with High Oral Bioavailability.
Bei Zhang, Yanhong Li, Yukang Lin, Ting Wang, Lin Chen, Wenwei You

J Med Chem· January 2025

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Design, synthesis, and biological evaluation of N-(pyridin-3-yl)pyrimidin-4-amine analogues as novel cyclin-dependent kinase 2 inhibitors for cancer therapy.
Wen-Bin Zeng, Tang-Yang Ji, Yan-Ting Zhang, Yu-Feng Ma, Rou Li, Wen-Wei You

Bioorg Chem· February 2024

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Synthesis and biological evaluation of novel 5-substituted/unsubstituted triazolothiadiazines as tubulin depolymerizing and vascular disrupting agents with promising antitumor activity.
Xian-Sen Huo, Ji Tang-Yang, Wen-Bin Zeng, Xie-Er Jian, Xuan-Xuan Ma, You Wen-Wei

Drug Dev Res· August 2023

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Discovery of novel 6-p-tolyl-3-(3,4,5-trimethoxybenzyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivative as a potent tubulin inhibitor with promising in vivo antitumor activity.
Tangyang Ji, Xieer Jian, Lin Chen, Wenbin Zeng, Xiansen Huo, Wenwei You

Eur J Med Chem· August 2023

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Rational design, synthesis and biological evaluation of novel 2-(substituted amino)-[1,2,4]triazolo[1,5-a]pyrimidines as novel tubulin polymerization inhibitors.
Lin Chen, Tang-Yang Ji, Xian-Sen Huo, Zhi-Yu Zeng, Wei-Xuan Ye, Wen-Wei You

Eur J Med Chem· December 2022

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Efficient synthesis and evaluation of novel 6-arylamino-[1,2,4]triazolo[4,3-a]pyridine derivatives as antiproliferative agents.
Man-Yu Lin, Tang-Yang Ji, Miao Zheng, Yan-Yan Chen, Shi-Yi Xu, Wen-Wei You

Bioorg Med Chem Lett· November 2022

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Concise synthesis and preliminary biological evaluation of new triazolylthioacetone derivatives bearing pyridine, pyrazine, and 3,4,5-trimethoxybenzyl fragment.
Lin Chen, Bei Zhang, Yan-Hong Li, Xian-Sen Huo, Wen-Wei You

Bioorg Med Chem Lett· June 2022

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Development of pteridin-7(8H)-one analogues as highly potent cyclin-dependent kinase 4/6 inhibitors: Synthesis, structure-activity relationship, and biological activity.
Qiu Li, Lin Chen, Yu-Feng Ma, Xie-Er Jian, Jia-Hao Ji, Wen-Wei You

Bioorg Chem· November 2021

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Design, synthesis and antiproliferative activity of novel 2,4-diamino-5-methyleneaminopyrimidine derivatives as potential anticancer agents.
Qiu Li, Lin Chen, Xie-Er Jian, Dong-Xin Lv, Wen-Wei You

Bioorg Med Chem Lett· September 2021

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Discovery of highly potent tubulin polymerization inhibitors: Design, synthesis, and structure-activity relationships of novel 2,7-diaryl-[1,2,4]triazolo[1,5-a]pyrimidines.
Xian-Sen Huo, Xie-Er Jian, Jie Ou-Yang, Lin Chen, Fang Yang, Wen-Wei You

Eur J Med Chem· August 2021

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Synthesis, biological evaluation, and structure-activity relationships of new tubulin polymerization inhibitors based on 5-amino-1,2,4-triazole scaffold.
Fang Yang, Lin Chen, Jin-Mei Lai, Xie-Er Jian, Dong-Xin Lv, Wen-Wei You

Bioorg Med Chem Lett· April 2021

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Synthesis and antiproliferative evaluation of novel 8-cyclopentyl-7,8-dihydropteridin-6(5H)-one derivatives as potential anticancer agents.
Qiu Li, Xie-Er Jian, Yu-Feng Ma, Lin Chen, Xian-Sen Huo, Wen-Wei You

Bioorg Med Chem Lett· January 2021

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Development of triazolothiadiazine derivatives as highly potent tubulin polymerization inhibitors: Structure-activity relationship, in vitro and in vivo study.
Weifeng Ma, Peng Chen, Xiansen Huo, Yufeng Ma, Yanhong Li, Wenwei You

Eur J Med Chem· December 2020

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Synthesis, and biological evaluation of 3,6-diaryl-[1,2,4]triazolo[4,3-a]pyridine analogues as new potent tubulin polymerization inhibitors.
Fang Yang, Xie-Er Jian, Peng-Cheng Diao, Xian-Sen Huo, Wen-Wei You

Eur J Med Chem· October 2020

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Synthesis and biological evaluation of benzofuran-based 3,4,5-trimethoxybenzamide derivatives as novel tubulin polymerization inhibitors.
Qiu Li, Xie-Er Jian, Zhi-Ru Chen, Lin Chen, Xian-Sen Huo, Wen-Wei You

Bioorg Chem· September 2020

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Synthesis and biological evaluation of novel pyrazolo[3,4-b]pyridines as cis-restricted combretastatin A-4 analogues.
Xie-Er Jian, Fang Yang, Cui-Shan Jiang, Wen-Wei You, Pei-Liang Zhao

Bioorg Med Chem Lett· April 2020

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Novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives as potent antitubulin agents: Design, multicomponent synthesis and antiproliferative activities.
Fang Yang, Liang-Zhentian Yu, Peng-Cheng Diao, Xie-Er Jian, Ming-Feng Zhou, Wen-Wei You

Bioorg Chem· November 2019

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Discovery of novel pyrimidine-based benzothiazole derivatives as potent cyclin-dependent kinase 2 inhibitors with anticancer activity.
Peng-Cheng Diao, Wei-Yuan Lin, Xie-Er Jian, Yan-Hong Li, Wen-Wei You

Eur J Med Chem· October 2019

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Facile one-pot synthesis, antiproliferative evaluation and structure-activity relationships of 3-amino-1H-indoles and 3-amino-1H-7-azaindoles.
Peng-Cheng Diao, Meng-Jin Hu, Hai-Kui Yang, Wen-Wei You, Pei-Liang Zhao

Bioorg Chem· July 2019

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Synthesis, biological evaluation, and molecular docking investigation of 3-amidoindoles as potent tubulin polymerization inhibitors.
Peng Chen, Yu-Xin Zhuang, Peng-Cheng Diao, Fang Yang, Shao-Yu Wu, Wen-Wei You

Eur J Med Chem· January 2019

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Design, synthesis and antiproliferative activity of novel substituted 2-amino-7,8-dihydropteridin-6(5H)-one derivatives.
Qiu Li, Hai-Kui Yang, Qi Sun, Wen-Wei You, Pei-Liang Zhao

Bioorg Med Chem Lett· September 2017

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Synthesis and biological evaluation of novel indole-pyrimidine hybrids bearing morpholine and thiomorpholine moieties.
Peng-Cheng Diao, Qiu Li, Meng-Jin Hu, Yu-Feng Ma, Wen-Wei You

Eur J Med Chem· July 2017

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Design, synthesis, and biological evaluation of novel alkylsulfanyl-1,2,4-triazoles as cis-restricted combretastatin A-4 analogues.
Yan-Hong Li, Bei Zhang, Hai-Kui Yang, Qiu Li, Peng-Cheng Diao, Wen-Wei You

Eur J Med Chem· January 2017

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Design, synthesis and antiproliferative activity of novel 5-nitropyrimidine-2,4-diamine derivatives bearing alkyl acetate moiety.
Pei-Liang Zhao, Yan-Hong Li, Hai-Kui Yang, Peng Chen, Bei Zhang, Wen-Wei You

Eur J Med Chem· August 2016

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Design, synthesis and biological evaluation of novel 3-alkylsulfanyl-4-amino-1,2,4-triazole derivatives.
Pei-Liang Zhao, Peng Chen, Qiu Li, Meng-Jin Hu, Peng-Cheng Diao, Wen-Wei You

Bioorg Med Chem Lett· August 2016

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