Publications by authors named "William Bonnette"

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Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction.
David Norton, William G Bonnette, James F Callahan, Maria G Carr, Charlotte M Griffiths-Jones

J Med Chem· November 2021

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Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer.
Zhuming Zhang, Avijit Ghosh, Peter J Connolly, Peter King, Thomas Wilde, William G Bonnette

J Med Chem· August 2021

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Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor.
Ryan M Wyatt, Ian Fraser, Natalie Welty, Brian Lord, Michelle Wennerholm, William Bonnette

J Pharmacol Exp Ther· March 2020

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Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors.
Dai-Shi Su, Junya Qu, Mark Schulz, Chuck W Blackledge, Hongyi Yu, William Bonnette

ACS Med Chem Lett· February 2020

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Modular Protein Ligation: A New Paradigm as a Reagent Platform for Pre-Clinical Drug Discovery.
Rosalie Matico, Lawrence M Szewczuk, Beth Pietrak, Stephanie Chen, Ed Dul, William G Bonnette

Sci Rep· September 2019

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Development of a high-content imaging assay for screening compound aggregation.
Yong Jiang, Ann Hoffman, Geoffrey Quinque, William G Bonnette, Lawrence M Szewczuk

Anal Biochem· October 2018

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A High-Throughput Dose-Response Cellular Thermal Shift Assay for Rapid Screening of Drug Target Engagement in Living Cells, Exemplified Using SMYD3 and IDO1.
Dean E McNulty, William G Bonnette, Hongwei Qi, Liping Wang, Thau F Ho

SLAS Discov· January 2018

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Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets.
Glenn S Van Aller, Alan P Graves, Patricia A Elkins, William G Bonnette, Patrick J McDevitt

Structure· May 2016

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Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity.
Nestor O Concha, Angela Smallwood, William Bonnette, Rachel Totoritis, Guofeng Zhang

Mol Pharmacol· December 2015

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A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC.
Helai P Mohammad, Kimberly N Smitheman, Chandrashekhar D Kamat, David Soong, Kelly E Federowicz, William G Bonnette

Cancer Cell· July 2015

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