Publications by authors named "Wing-Yu Fu"

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An missense variant decreases cholesterol efflux and confers Alzheimer's disease risk in the Chinese population.
Sze Kei Liu, Han Cao, Xin Yang, Xiaopu Zhou, Yu Chen, Wing-Yu Fu, Amy Ky Fu

J Alzheimers Dis· August 2025

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Astrocytic EphA4 signaling is important for the elimination of excitatory synapses in Alzheimer's disease.
Xin Yang, Ye Wang, Yi Qiao, Jingwen Lin, Jackie K Y Lau, Wing-Yu Fu, Amy K Y Fu

Proc Natl Acad Sci U S A· February 2025

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Transethnic analysis identifies SORL1 variants and haplotypes protective against Alzheimer's disease.
Xiaopu Zhou, Han Cao, Yuanbing Jiang, Yuewen Chen, Huan Zhong, Wing Yu Fu, Amy K Y Fu

Alzheimers Dement· January 2025

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Neuronal γ-secretase regulates synaptic functions via cholesterol homeostasis.
Wing-Yu Fu, Amy K Y Fu, Nancy Y Ip

Neuron· October 2023

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The role of genetic risk factors of Alzheimer's disease in synaptic dysfunction.
Wing-Yu Fu, Nancy Y Ip

Semin Cell Dev Biol· April 2023

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An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer's disease.
Yuanbing Jiang, Xiaopu Zhou, Hiu Yi Wong, Li Ouyang, Fanny C F Ip, Wing-Yu Fu, Amy K Y Fu

Nat Aging· July 2022

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Rhynchophylline Administration Ameliorates Amyloid-β Pathology and Inflammation in an Alzheimer's Disease Transgenic Mouse Model.
Wing-Yu Fu, Kwok-Wang Hung, Shun-Fat Lau, Busma Butt, Vincent Wai-Hin Yuen, Guangmiao Fu, Amy K Y Fu

ACS Chem Neurosci· November 2021

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Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer's disease transgenic mouse model.
Jackie K Y Lau, Min Tian, Yang Shen, Shun-Fat Lau, Wing-Yu Fu, Amy K Y Fu

Sci Rep· February 2021

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Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus.
Ye Wang, Wing-Yu Fu, Kit Cheung, Kwok-Wang Hung, Congping Chen, Amy K Y Fu

Proc Natl Acad Sci U S A· January 2021

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p39-associated Cdk5 activity regulates dendritic morphogenesis.
Li Ouyang, Yu Chen, Ye Wang, Yuewen Chen, Amy K Y Fu, Wing-Yu Fu

Sci Rep· October 2020

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IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer's Disease.
Shun-Fat Lau, Congping Chen, Wing-Yu Fu, Jianan Y Qu, Tom H Cheung, Amy K Y Fu

Cell Rep· April 2020

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Targeting Neuroinflammation as a Therapeutic Strategy for Alzheimer's Disease: Mechanisms, Drug Candidates, and New Opportunities.
Wing-Yu Fu, Xiujiao Wang, Nancy Y Ip

ACS Chem Neurosci· February 2019

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Increased Axin expression enhances adult hippocampal neurogenesis and exerts an antidepressant effect.
Wei-Wei Chen, Wing-Yu Fu, Yi-Ting Su, Wei-Qun Fang, Amy K Y Fu

Sci Rep· February 2019

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Identification of new EphA4 inhibitors by virtual screening of FDA-approved drugs.
Shuo Gu, Wing-Yu Fu, Amy K Y Fu, Estella Pui Sze Tong, Fanny C F Ip

Sci Rep· May 2018

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Axin Regulates Dendritic Spine Morphogenesis through Cdc42-Dependent Signaling.
Yu Chen, Zhuoyi Liang, Erkang Fei, Yuewen Chen, Xiaopu Zhou, Wing-Yu Fu, Amy K Y Fu

PLoS One· May 2016

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IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline.
Amy K Y Fu, Kwok-Wang Hung, Michael Y F Yuen, Xiaopu Zhou, Deejay S Y Mak, Wing-Yu Fu

Proc Natl Acad Sci U S A· May 2016

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p35 regulates the CRM1-dependent nucleocytoplasmic shuttling of nuclear hormone receptor coregulator-interacting factor 1 (NIF-1).
Xiao-Su Zhao, Wing-Yu Fu, Winnie W Y Chien, Zhen Li, Amy K Y Fu

PLoS One· December 2015

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S-nitrosylation-dependent proteasomal degradation restrains Cdk5 activity to regulate hippocampal synaptic strength.
Peng Zhang, Wing-Yu Fu, Amy K Y Fu, Nancy Y Ip

Nat Commun· October 2015

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Anemoside A3 Enhances Cognition through the Regulation of Synaptic Function and Neuroprotection.
Fanny C F Ip, Wing-Yu Fu, Elaine Y L Cheng, Estella P S Tong, Ka-Chun Lok

Neuropsychopharmacology· July 2015

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Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease.
Amy K Y Fu, Kwok-Wang Hung, Huiqian Huang, Shuo Gu, Yang Shen, Wing-Yu Fu

Proc Natl Acad Sci U S A· July 2014

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Cdk5 phosphorylates a component of the HDAC complex and regulates histone acetylation during neuronal cell death.
Amy K Y Fu, Kwok-Wang Hung, Hovy Ho-Wai Wong, Wing-Yu Fu, Nancy Y Ip

Neurosignals· January 2014

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Melanocortin-4 receptor regulates hippocampal synaptic plasticity through a protein kinase A-dependent mechanism.
Yang Shen, Wing-Yu Fu, Elaine Y L Cheng, Amy K Y Fu, Nancy Y Ip

J Neurosci· January 2013

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Ankyrin repeat-rich membrane spanning protein (kidins220) is required for neurotrophin and ephrin receptor-dependent dendrite development.
Yu Chen, Wing-Yu Fu, Jacque P K Ip, Tao Ye, Amy K Y Fu

J Neurosci· June 2012

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α2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2.
Jacque P K Ip, Lei Shi, Yu Chen, Yasuhiro Itoh, Wing-Yu Fu, Amy K Y Fu

Nat Neurosci· December 2011

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APC(Cdh1) mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity.
Amy K Y Fu, Kwok-Wang Hung, Wing-Yu Fu, Chong Shen, Yu Chen

Nat Neurosci· February 2011

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