Publications by authors named "Wouter N Leonhard"

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Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease.
Anish A Kanhai, Elena Sánchez-López, Thomas B Kuipers, Jan B van Klinken, Kyra L Dijkstra, Wouter N Leonhard

iScience· November 2023

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Preclinical evaluation of tolvaptan and salsalate combination therapy in a -mouse model.
Xuewen Song, Wouter N Leonhard, Anish A Kanhai, Gregory R Steinberg, York Pei

Front Mol Biosci· January 2023

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Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial.
Bart J Kramers, Iris W Koorevaar, Maatje D A van Gastel, Harry van Goor, Kenneth R Hallows, Wouter N Leonhard

Clin J Am Soc Nephrol· April 2022

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In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycystic kidney disease.
Tijmen H Booij, Wouter N Leonhard, Hester Bange, Kuan Yan, Michiel Fokkelman

J Mol Cell Biol· August 2020

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Renal cyst growth is attenuated by a combination treatment of tolvaptan and pioglitazone, while pioglitazone treatment alone is not effective.
Anish A Kanhai, Hester Bange, Lotte Verburg, Kyra L Dijkstra, Leo S Price, Wouter N Leonhard

Sci Rep· February 2020

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Prioritization of novel ADPKD drug candidates from disease-stage specific gene expression profiles.
Tareq B Malas, Wouter N Leonhard, Hester Bange, Zoraide Granchi, Kristina M Hettne

EBioMedicine· January 2020

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Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease.
Wouter N Leonhard, Xuewen Song, Anish A Kanhai, Ioan-Andrei Iliuta, Andrea Bozovic

EBioMedicine· September 2019

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Folate-dactolisib conjugates for targeting tubular cells in polycystic kidneys.
Haili Shi, Wouter N Leonhard, Niels J Sijbrandi, Mies J van Steenbergen, Marcel H A M Fens

J Control Release· January 2019

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Comparative transcriptomics of shear stress treated Pkd1 cells and pre-cystic kidneys reveals pathways involved in early polycystic kidney disease.
Steven J Kunnen, Tareq B Malas, Chiara Formica, Wouter N Leonhard, Peter A C 't Hoen

Biomed Pharmacother· December 2018

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Polycystin-1 dysfunction impairs electrolyte and water handling in a renal precystic mouse model for ADPKD.
Eric H J Verschuren, Sami G Mohammed, Wouter N Leonhard, Caro Overmars-Bos, Kimberly Veraar

Am J Physiol Renal Physiol· September 2018

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High-Throughput Phenotypic Screening of Kinase Inhibitors to Identify Drug Targets for Polycystic Kidney Disease.
Tijmen H Booij, Hester Bange, Wouter N Leonhard, Kuan Yan, Michiel Fokkelman

SLAS Discov· September 2017

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Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2.
Steven J Kunnen, Wouter N Leonhard, Cor Semeins, Lukas J A C Hawinkels, Christian Poelma

Cell Mol Life Sci· June 2017

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Meta-analysis of polycystic kidney disease expression profiles defines strong involvement of injury repair processes.
Tareq B Malas, Chiara Formica, Wouter N Leonhard, Pooja Rao, Zoraide Granchi

Am J Physiol Renal Physiol· April 2017

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STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease.
Maria Fragiadaki, Morgane Lannoy, Madeleine Themanns, Barbara Maurer, Wouter N Leonhard

Kidney Int· March 2017

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Inhibition of Activin Signaling Slows Progression of Polycystic Kidney Disease.
Wouter N Leonhard, Steven J Kunnen, Anna J Plugge, Arja Pasternack, Sebastian B T Jianu

J Am Soc Nephrol· December 2016

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Variable Cyst Development in Autosomal Dominant Polycystic Kidney Disease: The Biologic Context.
Wouter N Leonhard, Hester Happe, Dorien J M Peters

J Am Soc Nephrol· December 2016

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Proteomics of Urinary Vesicles Links Plakins and Complement to Polycystic Kidney Disease.
Mahdi Salih, Jeroen A Demmers, Karel Bezstarosti, Wouter N Leonhard, Monique Losekoot

J Am Soc Nephrol· October 2016

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Scattered Deletion of PKD1 in Kidneys Causes a Cystic Snowball Effect and Recapitulates Polycystic Kidney Disease.
Wouter N Leonhard, Malu Zandbergen, Kimberley Veraar, Susan van den Berg, Louise van der Weerd

J Am Soc Nephrol· June 2015

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Urine Fetuin-A is a biomarker of autosomal dominant polycystic kidney disease progression.
Nathalie Piazzon, Florian Bernet, Linda Guihard, Wouter N Leonhard, Séverine Urfer

J Transl Med· March 2015

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Cyst expansion and regression in a mouse model of polycystic kidney disease.
Hester Happé, Annemieke M van der Wal, Daniela C F Salvatori, Wouter N Leonhard, Martijn H Breuning

Kidney Int· June 2013

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Dose-dependent effects of sirolimus on mTOR signaling and polycystic kidney disease.
Zlata Novalic, Annemieke M van der Wal, Wouter N Leonhard, Gudrun Koehl, Martijn H Breuning

J Am Soc Nephrol· May 2012

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Curcumin inhibits cystogenesis by simultaneous interference of multiple signaling pathways: in vivo evidence from a Pkd1-deletion model.
Wouter N Leonhard, Annemieke van der Wal, Zlata Novalic, Steven J Kunnen, Ron T Gansevoort

Am J Physiol Renal Physiol· May 2011

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Altered Hippo signalling in polycystic kidney disease.
Hester Happé, Annemieke M van der Wal, Wouter N Leonhard, Steven J Kunnen, Martijn H Breuning

J Pathol· May 2011

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Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease.
Sabrine Hassane, Wouter N Leonhard, Annemieke van der Wal, Lukas Jac Hawinkels, Irma S Lantinga-van Leeuwen

J Pathol· September 2010

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Rapid high-throughput analysis of DNaseI hypersensitive sites using a modified Multiplex Ligation-dependent Probe Amplification approach.
Thomas Ohnesorg, Stefanie Eggers, Wouter N Leonhard, Andrew H Sinclair, Stefan J White

BMC Genomics· September 2009

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