Publications by authors named "Xiwen Gu"

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Genetic complexity underlies clinical heterogeneity: YWTD β-propeller mutations and second-hit modifier mutations in LRP6-related tooth agenesis and ectodermal dysplasia in human.
Xinxin Dong, Miao Yu, Zhaoyang Jia, Jinye Bai, Jing Zhang, Limin Guan, Xiwen Gu

Genes Dis· November 2025

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[Corrigendum] Propranolol induces hemangioma endothelial cell apoptosis via a p53‑BAX mediated pathway.
Tian-Hua Yao, Arekejiang Pataer, Krishna Prasad Regmi, Xi-Wen Gu, Quan-Yan Li

Mol Med Rep· October 2025

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Unraveling bidirectional evolution of unstable mitochondrial DNA mutations in hepatocellular carcinoma at single-cell resolution.
Kaixiang Zhou, Zhenni Wang, Wenjie Guo, Fanfan Xie, Qing Yuan, Shanshan Guo, Xiwen Gu, Xu Guo

Hepatology· July 2025

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IDH1 mutation inhibits differentiation of astrocytes and glioma cells with low oxoglutarate dehydrogenase expression by disturbing α-ketoglutarate-related metabolism and epigenetic modification.
Yuanlin Zhao, Ying Yang, Risheng Yang, Chao Sun, Xing Gao, Xiwen Gu, Yu Gu

Life Metab· April 2024

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Mutational profiling of mitochondrial DNA reveals an epithelial ovarian cancer-specific evolutionary pattern contributing to high oxidative metabolism.
Fanfan Xie, Wenjie Guo, Xingguo Wang, Kaixiang Zhou, Shanshan Guo, Xiwen Gu

Clin Transl Med· January 2024

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Metastatic pattern of ovarian cancer delineated by tracing the evolution of mitochondrial DNA mutations.
Zhiyang Xu, Kaixiang Zhou, Zhenni Wang, Yang Liu, Xingguo Wang, Xiwen Gu

Exp Mol Med· July 2023

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mitoSomatic: a tool for accurate identification of mitochondrial DNA somatic mutations without paired controls.
Wenjie Guo, Yang Liu, Liping Su, Shanshan Guo, Fanfan Xie, Xu Guo, Xiwen Gu

Mol Oncol· May 2023

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A Sound and Vibration Fusion Method for Fault Diagnosis of Rolling Bearings under Speed-Varying Conditions.
Haibo Wan, Xiwen Gu, Shixi Yang, Yanni Fu

Sensors (Basel)· March 2023

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Mutational signature of mtDNA confers mechanistic insight into oxidative metabolism remodeling in colorectal cancer.
Wenjie Guo, Yang Liu, Xiaoying Ji, Shanshan Guo, Fanfan Xie, Xu Guo, Xiwen Gu

Theranostics· January 2023

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Mutational profiling of mtDNA control region reveals tumor-specific evolutionary selection involved in mitochondrial dysfunction.
Xiaoying Ji, Wenjie Guo, Xiwen Gu, Shanshan Guo, Kaixiang Zhou, Xu Guo

EBioMedicine· June 2022

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mitoDataclean: A machine learning approach for the accurate identification of cross-contamination-derived tumor mitochondrial DNA mutations.
Liping Su, Shanshan Guo, Wenjie Guo, Xiaoying Ji, Yang Liu, Xu Guo, Xiwen Gu

Int J Cancer· May 2022

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Next-Generation Sequencing-Based Analysis of Urine Cell-Free mtDNA Reveals Aberrant Fragmentation and Mutation Profile in Cancer Patients.
Kaixiang Zhou, Yang Liu, Qing Yuan, Dong Lai, Shanshan Guo, Wenjie Guo, Xiwen Gu, Xu Guo

Clin Chem· March 2022

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Multiple-level copy number variations in cell-free DNA for prognostic prediction of HCC with radical treatments.
Yang Wang, Kaixiang Zhou, Xiangxu Wang, Yang Liu, Dongnan Guo, Xiwen Gu, Xu Guo

Cancer Sci· November 2021

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Mitochondrial DNA haplogroup M7 confers a reduced risk of colorectal cancer in a Han population from northern China.
Qing Yuan, Liping Su, Tian Wang, Yang Liu, Zhenxing Lu, Shanshan Guo, Xiwen Gu, Xu Guo

J Cell Mol Med· August 2021

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An innovative data analysis strategy for accurate next-generation sequencing detection of tumor mitochondrial DNA mutations.
Shanshan Guo, Kaixiang Zhou, Qing Yuan, Liping Su, Yang Liu, Xiwen Gu, Xu Guo

Mol Ther Nucleic Acids· March 2021

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NGS-based accurate and efficient detection of circulating cell-free mitochondrial DNA in cancer patients.
Yang Liu, Kaixiang Zhou, Shanshan Guo, Yang Wang, Xiaoying Ji, Xu Guo, Xiwen Gu

Mol Ther Nucleic Acids· March 2021

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Optimized high-fidelity 3DPCR to assess potential mitochondrial targeting by activation-induced cytidine deaminase.
Haiyan Wu, Kaili Zhang, Yue Chen, Jinfeng Li, Matthew P Strout, Xiwen Gu

FEBS Open Bio· September 2020

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Mutation signatures in germline mitochondrial genome provide insights into human mitochondrial evolution and disease.
Xiwen Gu, Xinyun Kang, Jiankang Liu

Hum Genet· June 2019

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Propranolol induces hemangioma endothelial cell apoptosis via a p53‑BAX mediated pathway.
Tian-Hua Yao, Parekejiang Pataer, Krishna Prasad Regmi, Xi-Wen Gu, Quan-Yan Li

Mol Med Rep· July 2018

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AID-associated DNA repair pathways regulate malignant transformation in a murine model of BCL6-driven diffuse large B-cell lymphoma.
Xiwen Gu, Carmen J Booth, Zongzhi Liu, Matthew P Strout

Blood· January 2016

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A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination.
Bao Q Vuong, Kayleigh Herrick-Reynolds, Bharat Vaidyanathan, Joseph N Pucella, Anna J Ucher, Xiwen Gu

Nat Immunol· November 2013

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The role of activation-induced cytidine deaminase in lymphomagenesis.
Xiwen Gu, Velizar Shivarov, Matthew P Strout

Curr Opin Hematol· July 2012

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The circadian clock influences heart performance.
Xi Wu, Zhiwei Liu, Guangsen Shi, Lijuan Xing, Xiaohan Wang, Xiwen Gu

J Biol Rhythms· October 2011

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Interaction of MAGED1 with nuclear receptors affects circadian clock function.
Xiaohan Wang, Jing Tang, Lijuan Xing, Guangsen Shi, Haibin Ruan, Xiwen Gu

EMBO J· April 2010

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