Publications by authors named "Yian Cheng"

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Development of a tumor-region-selective activation monoclonal antibody targeting the 4-1BB receptor for enhanced therapeutic efficacy and safety.
Tzu-Yi Liao, Yen-Ling Liu, Chiao-Yun Chen, Bing-Tsung Wu, En-Shuo Liu, Bo-Cheng Huang, Yi-An Cheng, Tian-Lu Cheng

Int J Biol Macromol· May 2025

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Protease-activated anti-Lewis Y antibody enhances selectivity and safety of glycan-targeting cancer therapy.
Wen-Han Lee, Ying-Rou Shen, Bo-Cheng Huang, Kai-Wen Ho, Ching-Kuei Chen, Yi-An Cheng, Tian-Lu Cheng

Int J Biol Macromol· May 2025

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Integrating molecular dynamics simulation with small- and wide-angle X-ray scattering to unravel the flexibility, antigen-blocking, and protease-restoring functions in a hindrance-based pro-antibody.
Jun Min Liao, Shih-Ting Hong, Yeng-Tseng Wang, Yi-An Cheng, Kai-Wen Ho, Tian-Lu Cheng

Protein Sci· September 2024

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A novel anti-tumor/anti-tumor-associated fibroblast/anti-mPEG tri-specific antibody to maximize the efficacy of mPEGylated nanomedicines against fibroblast-rich solid tumor.
Michael Chen, Ming-Thau Sheu, Tian-Lu Cheng, Steve R Roffler, Shyr-Yi Lin, Yi-An Cheng, Jing-Jy Cheng

Biomater Sci· December 2021

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Selective activation of pro-anti-IL-1β antibody enhances specificity for autoinflammatory disorder therapy.
Wen-Wei Lin, Yun-Chi Lu, Bo-Cheng Huang, Chih-Hung Chuang, Yi-An Cheng, Tian-Lu Cheng

Sci Rep· July 2021

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Enhancement of tumor tropism of mPEGylated nanoparticles by anti-mPEG bispecific antibody for ovarian cancer therapy.
Wen-Wei Lin, Yi-An Cheng, Chia-Ching Li, Kai-Wen Ho, Huei-Jen Chen, Bo-Cheng Huang, Chiu-Min Cheng, Tian-Lu Cheng

Sci Rep· April 2021

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Double attack strategy for leukemia using a pre-targeting bispecific antibody (CD20 Ab-mPEG scFv) and actively attracting PEGylated liposomal doxorubicin to enhance anti-tumor activity.
Kai-Wen Ho, I-J U Chen, Yi-An Cheng, Tzu-Yi Liao, En-Shuo Liu, Yu-Cheng Su, Bo-Cheng Huang, Tian-Lu Cheng

J Nanobiotechnology· January 2021

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Gut Fecal Microbiota Transplant in a Mouse Model of Orthotopic Rectal Cancer.
Yen-Cheng Chen, Zhi-Feng Miao, Kwan-Ling Yip, Yi-An Cheng, Chung-Jung Liu, Tian-Lu Cheng

Front Oncol· October 2020

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Humanized bispecific antibody (mPEG × HER2) rapidly confers PEGylated nanoparticles tumor specificity for multimodality imaging in breast cancer.
Yi-An Cheng, Tung-Ho Wu, Yun-Ming Wang, Tian-Lu Cheng, I-Ju Chen

J Nanobiotechnology· August 2020

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Bispecific antibody (HER2 × mPEG) enhances anti-cancer effects by precise targeting and accumulation of mPEGylated liposomes.
I-Ju Chen, Yi-An Cheng, Kai-Wen Ho, Wen-Wei Lin, Kai-Wen Cheng, Yu-Cheng Su, Tian-Lu Cheng

Acta Biomater· July 2020

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Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer.
Yi-An Cheng, I-Ju Chen, Yu-Cheng Su, Kai-Wen Cheng, Yun-Chi Lu, Tian-Lu Cheng

Biomater Sci· August 2019

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Use of syngeneic cells expressing membrane-bound GM-CSF as an adjuvant to induce antibodies against native multi-pass transmembrane protein.
Chien-Chiao Huang, Kai-Wen Cheng, Yuan-Chin Hsieh, Wen-Wei Lin, Chiu-Min Cheng, Yi-An Cheng, Bo-Cheng Huang, Tian-Lu Cheng

Sci Rep· July 2019

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Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy.
Yun-Chi Lu, Chih-Hung Chuang, Kuo-Hsiang Chuang, I-Ju Chen, Bo-Cheng Huang, Yi-An Cheng, Kai-Wen Cheng, Tian-Lu Cheng

PLoS Biol· June 2019

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Ten hub genes associated with progression and prognosis of pancreatic carcinoma identified by co-expression analysis.
Zhou Zhou, Yian Cheng, Yinan Jiang, Shi Liu, Meng Zhang

Int J Biol Sci· April 2019

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Pharmacological inhibition of bacterial β-glucuronidase prevents irinotecan-induced diarrhea without impairing its antitumor efficacy in vivo.
Kai-Wen Cheng, Chih-Hua Tseng, Cherng-Chyi Tzeng, Yu-Lin Leu, Ta-Chun Cheng, Chiu-Min Cheng, Yi-An Cheng, Tian-Lu Cheng

Pharmacol Res· January 2019

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Selective antibody activation through protease-activated pro-antibodies that mask binding sites with inhibitory domains.
I-Ju Chen, Chih-Hung Chuang, Yuan-Chin Hsieh, Yun-Chi Lu, Wen-Wei Lin, Ta-Chun Cheng, Yi-An Cheng, Kai-Wen Cheng, Tian-Lu Cheng

Sci Rep· September 2017

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Enhancement Effect of a Variable Topology of a Membrane-Tethered Anti-Poly(ethylene glycol) Antibody on the Sensitivity for Quantifying PEG and PEGylated Molecules.
Wen-Wei Lin, Yi-An Cheng, Chien-Han Kao, Steve R Roffler, Yu-Chi Lee, Bo-Cheng Huang, Tian-Lu Cheng

Anal Chem· June 2017

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Optimization of an Anti-poly(ethylene glycol) (anti-PEG) Cell-Based Capture System To Quantify PEG and PEGylated Molecules.
Wen-Wei Lin, Yuan-Chin Hsieh, Yi-An Cheng, Kuo-Hsiang Chuang, Chien-Chiao Huang, Kai-Wen Cheng, Ta-Chun Cheng, Tian-Lu Cheng

Anal Chem· December 2016

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Possible sources of neuroprotection following subretinal silicon chip implantation in RCS rats.
Machelle T Pardue, Michael J Phillips, Hang Yin, Alcides Fernandes, Yian Cheng

J Neural Eng· March 2005

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