Publications by authors named "Yojiro Anzai"

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Enzyme engineering of cytochrome P450 RosC provides mechanistic insights into factors controlling iterative oxidation.
Yohei Iizaka, Hironori Suzuki, Nanako Sasa, Kihika Ishiuchi, Yuta Kumakiri, Yojiro Anzai

Appl Microbiol Biotechnol· December 2025

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Development of a CYP2D6-enhanced HepaRG cell model with improved CYP2D6 metabolic capacity.
Chizuka Obara, Yohei Iizaka, Akari Mine, Yojiro Anzai, Masako Tada

PLoS One· December 2025

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Inhibitory effects of reumycin produced by Streptomyces sp. TPMA0082 on virulence factors of Pseudomonas aeruginosa.
Jiahao Zeng, Yohei Iizaka, Yasuhiro Ouchi, Kouharu Otsuki, Takashi Kikuchi, Yojiro Anzai

J Nat Med· May 2025

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Unveiling dynamic hepatocyte plasticity in HepaRG cells with a dual CYP reporter system.
Riku Asano, Yohei Iizaka, Makoto Kashima, Yojiro Anzai, Shinpei Yamaguchi

PLoS One· November 2024

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Actinoplanes kirromycinicus sp. nov., isolated from soil.
Jiahao Zeng, Yohei Iizaka, Moriyuki Hamada, Aya Iwai, Riku Takeuchi, Yojiro Anzai

J Antibiot (Tokyo)· October 2024

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[Evaluation of the Stability and Antibacterial Activity of Burow's and Neo-Burow's Solutions was Prepared Using Different Methods].
Masako Kinoshita, Rina Yamagishi, Yohei Iizaka, Masaki Takigawa, Yojiro Anzai

Yakugaku Zasshi· September 2024

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Production of hybrid macrolide antibiotics by exploiting the specific substrate recognition characteristics of multifunctional cytochrome P450 enzyme MycG.
Yohei Iizaka, Mari Yamada, Suirei Koshino, Sawa Takahashi, Ryota Saito, Yojiro Anzai

FEMS Microbiol Lett· January 2024

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Isolation of Hydrazide-alkenes with Different Amino Acid Origins from an Azoxy-alkene-Producing Mutant of 7434AN4.
Yu Tanaka, Haruka Nagano, Mei Okano, Takuya Kishimoto, Ayaka Tatsukawa, Yojiro Anzai

J Nat Prod· September 2023

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Isolation, Biosynthetic Investigation, and Biological Evaluation of Maniwamycin G, an Azoxyalkene Compound from sp. TOHO-M025.
Ayaka Tatsukawa, Yu Tanaka, Haruka Nagano, Atsushi Fukumoto, Yojiro Anzai

J Nat Prod· July 2022

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Engineering sequence and selectivity of late-stage C-H oxidation in the MycG iterative cytochrome P450.
Yohei Iizaka, Ryusei Arai, Akari Takahashi, Mikino Ito, Miho Sakai, Yojiro Anzai

J Ind Microbiol Biotechnol· January 2022

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Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida.
Elinor Breiner-Goldstein, Zohar Eyal, Donna Matzov, Yehuda Halfon, Giuseppe Cimicata, Yojiro Anzai

Nucleic Acids Res· September 2021

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sp. nov., an endophytic actinomycete isolated from aerial parts of .
Natsagdorj Oyunbileg, Yohei Iizaka, Moriyuki Hamada, Bekh-Ochir Davaapurev, Atsushi Fukumoto, Yojiro Anzai

Int J Syst Evol Microbiol· July 2021

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An overview of the cytochrome P450 enzymes that catalyze the same-site multistep oxidation reactions in biotechnologically relevant selected actinomycete strains.
Yohei Iizaka, David H Sherman, Yojiro Anzai

Appl Microbiol Biotechnol· April 2021

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Quorum Sensing Inhibitors against Chromobacterium violaceum CV026 Derived from an Actinomycete Metabolite Library.
Toshiko Ohta, Atsushi Fukumoto, Yohei Iizaka, Fumio Kato, Yasumasa Koyama, Yojiro Anzai

Biol Pharm Bull· November 2020

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Computational-Based Mechanistic Study and Engineering of Cytochrome P450 MycG for Selective Oxidation of 16-Membered Macrolide Antibiotics.
Song Yang, Matthew D DeMars, Jessica M Grandner, Noelle M Olson, Yojiro Anzai

J Am Chem Soc· October 2020

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Artificial control of the multistep oxidation reactions catalyzed by the cytochrome P450 enzyme RosC.
Yohei Iizaka, Hiroshi Kanai, Tomoko Suzuki, Yuna Maruyama, Misa Kurita, Yojiro Anzai

Appl Microbiol Biotechnol· April 2020

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Monitoring the colonization and infection of legume nodules by Micromonospora in co-inoculation experiments with rhizobia.
Patricia Benito, Pablo Alonso-Vega, Carolina Aguado, Rafael Luján, Yojiro Anzai

Sci Rep· September 2017

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Cytochrome P450 enzyme RosC catalyzes a multistep oxidation reaction to form the non-active compound 20-carboxyrosamicin.
Yohei Iizaka, Rina Takeda, Yuki Senzaki, Atsushi Fukumoto, Yojiro Anzai

FEMS Microbiol Lett· July 2017

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Maniwamycins: new quorum-sensing inhibitors against Chromobacterium violaceum CV026 were isolated from Streptomyces sp. TOHO-M025.
Atsushi Fukumoto, Chikana Murakami, Yojiro Anzai, Fumio Kato

J Antibiot (Tokyo)· May 2016

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Structural basis of substrate specificity and regiochemistry in the MycF/TylF family of sugar O-methyltransferases.
Steffen M Bernard, David L Akey, Ashootosh Tripathi, Sung Ryeol Park, Jamie R Konwerski, Yojiro Anzai

ACS Chem Biol· May 2015

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A new mycinosyl rosamicin derivative produced by an engineered Micromonospora rosaria mutant with a cytochrome P450 gene disruption introducing the D-mycinose biosynthetic gene.
Yohei Iizaka, Noriko Higashi, Wei Li, Atsushi Fukumoto, Yojiro Anzai

J Ind Microbiol Biotechnol· September 2014

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New reactions and products resulting from alternative interactions between the P450 enzyme and redox partners.
Wei Zhang, Yi Liu, Jinyong Yan, Shaona Cao, Fali Bai, Yojiro Anzai

J Am Chem Soc· March 2014

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Isolation and structural elucidation of novel cholestane glycosides and spirostane saponins from Polygonatum odoratum.
Hong Bai, Wei Li, Huanxin Zhao, Yojiro Anzai, Haiming Li

Steroids· February 2014

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Function of cytochrome P450 enzymes RosC and RosD in the biosynthesis of rosamicin macrolide antibiotic produced by Micromonospora rosaria.
Yohei Iizaka, Noriko Higashi, Masanari Ishida, Reina Oiwa, Yumi Ichikawa, Yojiro Anzai

Antimicrob Agents Chemother· March 2013

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Substrate recognition by the multifunctional cytochrome P450 MycG in mycinamicin hydroxylation and epoxidation reactions.
Shengying Li, Drew R Tietz, Florentine U Rutaganira, Petrea M Kells, Yojiro Anzai

J Biol Chem· November 2012

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