Publications by authors named "Yusuke Marikawa"

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Embryotoxicity analysis of anti-arrhythmia drugs amiodarone, dronedarone, and their metabolites using 3D gastruloid models.
Courtney Kehaulani Kurashima, Yusuke Marikawa

Reprod Toxicol· December 2025

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Detection of developmental toxicity of the anti-COVID-19 drug molnupiravir using gastruloid-based in vitro assays.
Margaret Carrell Huntsman, Yusuke Marikawa

Toxicol Sci· September 2025

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Regulation of trophectoderm morphogenesis by small GTPase RHOA through HIPPO signaling-dependent and -independent mechanisms in mouse preimplantation development.
Yusuke Marikawa, Vernadeth B Alarcon

Differentiation· May 2025

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Validation of a mouse 3D gastruloid-based embryotoxicity assay in reference to the ICH S5(R3) guideline chemical exposure list.
Margaret Carrell Huntsman, Courtney Kehaulani Kurashima, Yusuke Marikawa

Reprod Toxicol· April 2024

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An active metabolite of the anti-COVID-19 drug molnupiravir impairs mouse preimplantation embryos at clinically relevant concentrations.
Yusuke Marikawa, Vernadeth B Alarcon

Reprod Toxicol· October 2023

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Developmental toxicity of remdesivir, an anti-COVID-19 drug, is implicated by in vitro assays using morphogenetic embryoid bodies of mouse and human pluripotent stem cells.
Lauren Kirkwood-Johnson, Yusuke Marikawa

Birth Defects Res· January 2023

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Toward better assessments of developmental toxicity using stem cell-based in vitro embryogenesis models.
Yusuke Marikawa

Birth Defects Res· October 2022

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Trophectoderm formation: regulation of morphogenesis and gene expressions by RHO, ROCK, cell polarity, and HIPPO signaling.
Vernadeth B Alarcon, Yusuke Marikawa

Reproduction· October 2022

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Gastruloids: Pluripotent stem cell models of mammalian gastrulation and embryo engineering.
Alfonso Martinez Arias, Yusuke Marikawa, Naomi Moris

Dev Biol· August 2022

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Remdesivir impairs mouse preimplantation embryo development at therapeutic concentrations.
Yusuke Marikawa, Vernadeth B Alarcon

Reprod Toxicol· August 2022

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Ancestral Stem Cell Reprogramming Genes Active in Hemichordate Regeneration.
Tom Humphreys, Keith Weiser, Asuka Arimoto, Akane Sasaki, Gene Uenishi, Yusuke Marikawa

Front Ecol Evol· February 2022

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Dolutegravir Impairs Stem Cell-Based 3D Morphogenesis Models in a Manner Dependent on Dose and Timing of Exposure: An Implication for Its Developmental Toxicity.
Lauren Kirkwood-Johnson, Nana Katayama, Yusuke Marikawa

Toxicol Sci· November 2021

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Regulation of endoplasmic reticulum stress and trophectoderm lineage specification by the mevalonate pathway in the mouse preimplantation embryo.
Yusuke Marikawa, Mark Menor, Youping Deng, Vernadeth B Alarcon

Mol Hum Reprod· March 2021

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Methoxyacetic acid inhibits histone deacetylase and impairs axial elongation morphogenesis of mouse gastruloids in a retinoic acid signaling-dependent manner.
Aileen S W Li, Yusuke Marikawa

Birth Defects Res· August 2020

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ROCK and RHO Playlist for Preimplantation Development: Streaming to HIPPO Pathway and Apicobasal Polarity in the First Cell Differentiation.
Vernadeth B Alarcon, Yusuke Marikawa

Adv Anat Embryol Cell Biol· February 2020

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Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells.
Yusuke Marikawa, Hong-Ru Chen, Mark Menor, Youping Deng, Vernadeth B Alarcon

Reprod Toxicol· January 2020

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RHOA activity in expanding blastocysts is essential to regulate HIPPO-YAP signaling and to maintain the trophectoderm-specific gene expression program in a ROCK/actin filament-independent manner.
Yusuke Marikawa, Vernadeth B Alarcon

Mol Hum Reprod· February 2019

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Fluoxetine Inhibits Canonical Wnt Signaling to Impair Embryoid Body Morphogenesis: Potential Teratogenic Mechanisms of a Commonly Used Antidepressant.
Erica L L Warkus, Yusuke Marikawa

Toxicol Sci· October 2018

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Embryoid body test with morphological and molecular endpoints implicates potential developmental toxicity of trans-resveratrol.
Iris Q Kim, Yusuke Marikawa

Toxicol Appl Pharmacol· September 2018

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Developmental toxicity assessment of common excipients using a stem cell-based in vitro morphogenesis model.
Chloe J Yuan, Yusuke Marikawa

Food Chem Toxicol· November 2017

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Exposure-Based Validation of an In Vitro Gastrulation Model for Developmental Toxicity Assays.
Erica L L Warkus, Yusuke Marikawa

Toxicol Sci· May 2017

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Adverse effect of valproic acid on an in vitro gastrulation model entails activation of retinoic acid signaling.
Aileen S W Li, Yusuke Marikawa

Reprod Toxicol· December 2016

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Statins inhibit blastocyst formation by preventing geranylgeranylation.
Vernadeth B Alarcon, Yusuke Marikawa

Mol Hum Reprod· May 2016

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Use of In Vitro Morphogenesis of Mouse Embryoid Bodies to Assess Developmental Toxicity of Therapeutic Drugs Contraindicated in Pregnancy.
Erica L L Warkus, Angela A Y Q Yuen, Caroline G Y Lau, Yusuke Marikawa

Toxicol Sci· January 2016

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An in vitro gastrulation model recapitulates the morphogenetic impact of pharmacological inhibitors of developmental signaling pathways.
Aileen S W Li, Yusuke Marikawa

Mol Reprod Dev· December 2015

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