Publications by authors named "Yusuke Moritoh"

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Oral SSTR5 Antagonist SCO-240 for Growth Hormone Stimulation: A Phase I Single-Dose Study in Healthy Individuals.
Harunobu Nishizaki, Tomoya Kagawa, Jun Sugama, Akihiro Kobayashi, Yusuke Moritoh

Clin Pharmacol Ther· June 2024

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An Exploratory Randomized Trial of SCO-792, an Enteropeptidase Inhibitor, in Patients With Type 2 Diabetes and Albuminuria.
Tomoya Kagawa, Jun Sugama, Harunobu Nishizaki, Yusuke Moritoh, Masanori Watanabe

Kidney Int Rep· January 2023

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Liquid chromatography-mass spectrometry measurements of blood diphosphoinositol pentakisphosphate levels.
Akihiro Kobayashi, Shin-Ichi Abe, Masanori Watanabe, Yusuke Moritoh

J Chromatogr A· October 2022

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Dichloroacetate, a pyruvate dehydrogenase kinase inhibitor, ameliorates type 2 diabetes via reduced gluconeogenesis.
Yuko Katayama, Yayoi Kawata, Yusuke Moritoh, Masanori Watanabe

Heliyon· February 2022

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SCO-267, a GPR40 Full Agonist, Stimulates Islet and Gut Hormone Secretion and Improves Glycemic Control in Humans.
Harunobu Nishizaki, Osamu Matsuoka, Tomoya Kagawa, Akihiro Kobayashi, Masanori Watanabe, Yusuke Moritoh

Diabetes· October 2021

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Erratum. SCO-267, a GPR40 Full Agonist, Stimulates Islet and Gut Hormone Secretion and Improves Glycemic Control in Humans. Diabetes 2021;70:2364-2376.
Harunobu Nishizaki, Osamu Matsuoka, Tomoya Kagawa, Akihiro Kobayashi, Masanori Watanabe, Yusuke Moritoh

Diabetes· October 2021

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Erratum. SCO-267, a GPR40 Full Agonist, Stimulates Islet and Gut Hormone Secretion and Improves Glycemic Control in Humans. Diabetes 2021;70:2364-2376.
Harunobu Nishizaki, Osamu Matsuoka, Tomoya Kagawa, Akihiro Kobayashi, Masanori Watanabe, Yusuke Moritoh

Diabetes· October 2021

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The enzymatic activity of inositol hexakisphosphate kinase controls circulating phosphate in mammals.
Yusuke Moritoh, Shin-Ichi Abe, Hiroki Akiyama, Akihiro Kobayashi, Ryokichi Koyama

Nat Commun· August 2021

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Chronic Exposure to SCO-267, an Allosteric GPR40 Full Agonist, Is Effective in Improving Glycemic Control in Rats.
Ryokichi Koyama, Mitsugi Ookawara, Masanori Watanabe, Yusuke Moritoh

Mol Pharmacol· April 2021

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Enteropeptidase inhibitor SCO-792 effectively prevents kidney function decline and fibrosis in a rat model of chronic kidney disease.
Yuko Katayama, Jun Sugama, Tomohisa Suzuki, Yoshimasa Ishimura, Akihiro Kobayashi, Yusuke Moritoh

Nephrol Dial Transplant· March 2021

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Enteropeptidase inhibition improves kidney function in a rat model of diabetic kidney disease.
Jun Sugama, Yuko Katayama, Yusuke Moritoh, Masanori Watanabe

Diabetes Obes Metab· January 2021

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Enteropeptidase inhibition improves obesity by modulating gut microbiota composition and enterobacterial metabolites in diet-induced obese mice.
Jun Sugama, Yusuke Moritoh, Hiroaki Yashiro, Kazue Tsuchimori, Masanori Watanabe

Pharmacol Res· January 2021

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The GPR40 Full Agonist SCO-267 Improves Liver Parameters in a Mouse Model of Nonalcoholic Fatty Liver Disease without Affecting Glucose or Body Weight.
Mitsugi Ookawara, Keisuke Matsuda, Masanori Watanabe, Yusuke Moritoh

J Pharmacol Exp Ther· October 2020

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Design and Identification of a GPR40 Full Agonist () Possessing a 2-Carbamoylphenyl Piperidine Moiety.
Hideki Furukawa, Yasufumi Miyamoto, Yasuhiro Hirata, Koji Watanabe, Yuko Hitomi, Yusuke Moritoh

J Med Chem· September 2020

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GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve.
Hikaru Ueno, Ryo Ito, Shin-Ichi Abe, Hitomi Ogino, Minoru Maruyama, Yusuke Moritoh

PLoS One· March 2020

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SCO-792, an enteropeptidase inhibitor, improves disease status of diabetes and obesity in mice.
Hiroaki Yashiro, Kenichi Hamagami, Hideyuki Hiyoshi, Jun Sugama, Kazue Tsuchimori, Yusuke Moritoh

Diabetes Obes Metab· October 2019

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Discovery and characterization of a small-molecule enteropeptidase inhibitor, SCO-792.
Masako Sasaki, Ikuo Miyahisa, Sachiko Itono, Hiroaki Yashiro, Hideyuki Hiyoshi, Yusuke Moritoh

Pharmacol Res Perspect· October 2019

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SCO-267, a GPR40 Full Agonist, Improves Glycemic and Body Weight Control in Rat Models of Diabetes and Obesity.
Hikaru Ueno, Ryo Ito, Shin-Ichi Abe, Mitsugi Ookawara, Hirohisa Miyashita, Yusuke Moritoh

J Pharmacol Exp Ther· August 2019

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GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca channels.
Reshma Ramracheya, Caroline Chapman, Margarita Chibalina, Haiqiang Dou, Caroline Miranda, Yusuke Moritoh

Physiol Rep· September 2018

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Inositol Hexakisphosphate Kinase 3 Regulates Metabolism and Lifespan in Mice.
Yusuke Moritoh, Masahiro Oka, Yoshitaka Yasuhara, Hiroyuki Hozumi, Kimihiko Iwachidow

Sci Rep· August 2016

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Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554.
Hironobu Maezaki, Yoshihiro Banno, Yasufumi Miyamoto, Yusuke Moritoh, Tomoko Asakawa

Bioorg Med Chem· August 2011

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Discovery of a 3-pyridylacetic acid derivative (TAK-100) as a potent, selective and orally active dipeptidyl peptidase IV (DPP-4) inhibitor.
Yasufumi Miyamoto, Yoshihiro Banno, Tohru Yamashita, Tatsuhiko Fujimoto, Satoru Oi, Yusuke Moritoh

J Med Chem· February 2011

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Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125.
Yasufumi Miyamoto, Yoshihiro Banno, Tohru Yamashita, Tatsuhiko Fujimoto, Satoru Oi, Yusuke Moritoh

Bioorg Med Chem· January 2011

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Nuclear hormone retinoid X receptor (RXR) negatively regulates the glucose-stimulated insulin secretion of pancreatic ß-cells.
Satsuki Miyazaki, Hidenori Taniguchi, Yusuke Moritoh, Fumi Tashiro, Tsunehiko Yamamoto

Diabetes· November 2010

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GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.
Yang Z De Marinis, Albert Salehi, Caroline E Ward, Quan Zhang, Fernando Abdulkader, Yusuke Moritoh

Cell Metab· June 2010

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