Publications by authors named "Zengjun Fang"

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pH-triggered "PEG" sheddable and folic acid-targeted nanoparticles for docetaxel delivery in breast cancer treatment.
Fangqian Sui, Zengjun Fang, Lingjun Li, Xinhuan Wan, Yongqing Zhang

Int J Pharm· September 2023

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Ginsenoside Rb2: A review of pharmacokinetics and pharmacological effects.
Longxing Miao, Yijun Yang, Zhongwen Li, Zengjun Fang, Yongqing Zhang

J Ginseng Res· March 2022

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Screening, simulation, and optimization design of small molecule inhibitors of the SARS-CoV-2 spike glycoprotein.
Chuancai Sun, Jian Zhang, Jiao Wei, Xiaoli Zheng, Xianyang Zhao, Zengjun Fang

PLoS One· February 2021

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Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties.
Dongwei Kang, Da Feng, Yanying Sun, Zengjun Fang, Fenju Wei

J Med Chem· May 2020

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Stimuli-responsive charge-reversal nano drug delivery system: The promising targeted carriers for tumor therapy.
Zengjun Fang, Shaobin Pan, Peng Gao, Huagang Sheng, Lingjun Li

Int J Pharm· February 2020

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Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel.
Dongwei Kang, F Xavier Ruiz, Da Feng, Alyssa Pilch, Tong Zhao, Zengjun Fang

J Med Chem· February 2020

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Smart albumin-loaded Rose Bengal and doxorubicin nanoparticles for breast cancer therapy.
Jing Sun, Li Zhang, Ying Zhang, Chun-Wen Yue, Jia Lin, Zeng-Jun Fang

J Microencapsul· December 2019

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Discovery of novel anti-influenza agents via contemporary medicinal chemistry strategies (2014-2018 update).
Ruifang Jia, Jian Zhang, Han Ju, Dongwei Kang, Zengjun Fang

Future Med Chem· March 2019

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Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant.
Jian Zhang, Natarajan Arul Murugan, Ye Tian, Chiara Bertagnin, Zengjun Fang, Ruifang Jia, Wenfang Xu

J Med Chem· November 2018

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Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.
Jian Zhang, Vasanthanathan Poongavanam, Dongwei Kang, Chiara Bertagnin, Huamei Lu, Zengjun Fang, Ruifang Jia, Wenfang Xu

J Med Chem· July 2018

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Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants.
Dongwei Kang, Zengjun Fang, Boshi Huang, Xueyi Lu, Heng Zhang

J Med Chem· May 2017

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Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles.
Dongwei Kang, Zengjun Fang, Zhenyu Li, Boshi Huang, Heng Zhang

J Med Chem· September 2016

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A sensitive LC-MS/MS method to quantify methylergonovine in human plasma and its application to a pharmacokinetic study.
Yanhui Gao, Qichao Sun, Dongming Liu, Bowen Ma, Hengli Zhao, Zengjun Fang

J Chromatogr B Analyt Technol Biomed Life Sci· February 2016

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Synthesis and Preliminary Antiviral Activities of Piperidine-substituted Purines against HIV and Influenza A/H1N1 Infections.
Dongwei Kang, Zengjun Fang, Boshi Huang, Lingzi Zhang, Huiqing Liu

Chem Biol Drug Des· October 2015

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Synthesis and Biological Evaluation of a Series of 2-((1-substituted-1H-1,2,3-triazol-4-yl)methylthio)-6-(naphthalen-1-ylmethyl)pyrimidin-4(3H)-one As Potential HIV-1 Inhibitors.
Zengjun Fang, Dongwei Kang, Lingzi Zhang, Boshi Huang, Huiqing Liu

Chem Biol Drug Des· October 2015

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A liquid chromatography-tandem mass spectrometric assay for the antihypertensive agent azelnidipine in human plasma with application to clinical pharmacokinetics studies.
Yanhui Gao, Baoqiu Li, Baomeng Zhu, Dongming Liu, Hengli Zhao, Zengjun Fang

Biomed Chromatogr· July 2015

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Enhanced oral absorption and therapeutic effect of acetylpuerarin based on D-α-tocopheryl polyethylene glycol 1000 succinate nanoemulsions.
Deqing Sun, Xinbing Wei, Xia Xue, Zengjun Fang, Manru Ren

Int J Nanomedicine· March 2015

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Recent advances in the discovery and development of novel HIV-1 NNRTI platforms (Part II): 2009-2013 update.
Yu'ning Song, Zengjun Fang, Peng Zhan, Xinyong Liu

Curr Med Chem· July 2014

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Conformational restriction: an effective tactic in 'follow-on'-based drug discovery.
Zengjun Fang, Yu'ning Song, Peng Zhan, Qingzhu Zhang, Xinyong Liu

Future Med Chem· May 2014

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HIV-1 NNRTIs: structural diversity, pharmacophore similarity, and implications for drug design.
Peng Zhan, Xuwang Chen, Dongyue Li, Zengjun Fang, Erik De Clercq

Med Res Rev· June 2013

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1,2,3-thiadiazole thioacetanilides. Part 2: Synthesis and biological evaluation of a new series of 2-{[4-(3,4-dichlorophenyl)-1,2,3-thiadiazol-5-yl]sulfanyl}acetanilides as HIV-1 inhibitors.
Peng Zhan, Xin-Yong Liu, Zhen-Yu Li, Zeng-Jun Fang, Christophe Pannecouque

Chem Biodivers· July 2010

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Synthesis and anti-HIV activity evaluation of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)-N-acetamides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Peng Zhan, Xinyong Liu, Zengjun Fang, Zhenyu Li, Christophe Pannecouque

Eur J Med Chem· November 2009

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1,2,3-Selenadiazole thioacetanilides: synthesis and anti-HIV activity evaluation.
Peng Zhan, Xinyong Liu, Zengjun Fang, Christophe Pannecouque, Erik De Clercq

Bioorg Med Chem· September 2009

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Novel 1,2,3-thiadiazole derivatives as HIV-1 NNRTIs with improved potency: Synthesis and preliminary SAR studies.
Peng Zhan, Xinyong Liu, Zhenyu Li, Zengjun Fang, Zhong Li

Bioorg Med Chem· August 2009

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Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Peng Zhan, Xinyong Liu, Junjie Zhu, Zengjun Fang, Zhenyu Li

Bioorg Med Chem· August 2009

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