Publications by authors named "Zhengdong D Zhang"

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Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates.
Zhengdong D Zhang, Adam Frankish, Toby Hunt, Jennifer Harrow, Mark Gerstein

September 2010

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Prevalence and Spectrum of Congenital Heart Disease in Individuals With Distal Chromosome 22q11.22-23 Deletions.
Tanner J Nelson, Daniel E McGinn, T Blaine Crowley, Lydia Rockart, Audrey Green, Zhengdong D Zhang

Clin Genet· December 2025

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Genetic links between multimorbidity and human aging.
Phuong-Anh Dinh, HyeRim Han, Seungsoo Kim, Qinghua Guo, Zhengdong D Zhang

Geroscience· December 2025

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Ultrarare Variants in DNA Damage Repair Genes in Pediatric Acute-Onset Neuropsychiatric Syndrome or Acute Behavioral Regression in Neurodevelopmental Disorders.
Janet L Cunningham, Jennifer Frankovich, Robert A Dubin, Erika Pedrosa, Refia Nur Baykara, Zhengdong D Zhang

Dev Neurosci· September 2025

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Identification of functional rare coding variants in IGF-1 gene in humans with exceptional longevity.
Amanat Ali, Zhengdong D Zhang, Tina Gao, Sandra Aleksic, Evripidis Gavathiotis

Sci Rep· March 2025

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Genetic variants associated with age-related episodic memory decline implicate distinct memory pathologies.
Amanat Ali, Sofiya Milman, Erica F Weiss, Tina Gao, Valerio Napolioni, Zhengdong D Zhang

Alzheimers Dement· January 2025

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Depletion of loss-of-function germline mutations in centenarians reveals longevity genes.
Kejun Ying, José P Castro, Anastasia V Shindyapina, Alexander Tyshkovskiy, Mahdi Moqri, Zhengdong D Zhang

Nat Commun· October 2024

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Author Correction: Rare genetic coding variants associated with human longevity and protection against age-related diseases.
Jhih-Rong Lin, Patrick Sin-Chan, Valerio Napolioni, Guillermo G Torres, Joydeep Mitra, Quanwei Zhang, Zhengdong D Zhang

Nat Aging· September 2024

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Polygenic prediction of human longevity on the supposition of pervasive pleiotropy.
M Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang, Joydeep Mitra, Zhengdong D Zhang

Sci Rep· August 2024

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Rare genetic coding variants associated with age-related episodic memory decline implicate distinct memory pathologies in the hippocampus.
Amanat Ali, Sofiya Milman, Erica F Weiss, Tina Gao, Valerio Napolioni, Zhengdong D Zhang

medRxiv· May 2024

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Polygenic prediction of human longevity on the supposition of pervasive pleiotropy.
M Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang, Joydeep Mitra, Zhengdong D Zhang

medRxiv· December 2023

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Chromatin regulators in the TBX1 network confer risk for conotruncal heart defects in 22q11.2DS.
Yingjie Zhao, Yujue Wang, Lijie Shi, Donna M McDonald-McGinn, T Blaine Crowley, Zhengdong D Zhang

NPJ Genom Med· July 2023

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Rare coding variants as risk modifiers of the 22q11.2 deletion implicate postnatal cortical development in syndromic schizophrenia.
Jhih-Rong Lin, Yingjie Zhao, M Reza Jabalameli, Nha Nguyen, Joydeep Mitra, Zhengdong D Zhang

Mol Psychiatry· May 2023

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Protocol for gene annotation, prediction, and validation of genomic gene expansion.
Quanwei Zhang, Zhengdong D Zhang

STAR Protoc· December 2022

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Substance abuse and the risk of severe COVID-19: Mendelian randomization confirms the causal role of opioids but hints a negative causal effect for cannabinoids.
M Reza Jabalameli, Zhengdong D Zhang

Front Genet· December 2022

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Unravelling genetic components of longevity.
M Reza Jabalameli, Zhengdong D Zhang

Nat Aging· January 2022

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Genomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation.
Quanwei Zhang, Gregory Tombline, Julia Ablaeva, Lei Zhang, Xuming Zhou, Zhengdong D Zhang

Cell Rep· November 2021

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Deep post-GWAS analysis identifies potential risk genes and risk variants for Alzheimer's disease, providing new insights into its disease mechanisms.
Zhen Wang, Quanwei Zhang, Jhih-Rong Lin, M Reza Jabalameli, Joydeep Mitra, Zhengdong D Zhang

Sci Rep· October 2021

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Rare genetic coding variants associated with human longevity and protection against age-related diseases.
Jhih-Rong Lin, Patrick Sin-Chan, Valerio Napolioni, Guillermo G Torres, Joydeep Mitra, Quanwei Zhang, Zhengdong D Zhang

Nat Aging· September 2021

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Enhancer release and retargeting activates disease-susceptibility genes.
Soohwan Oh, Jiaofang Shao, Joydeep Mitra, Feng Xiong, Matteo D'Antonio, Zhengdong D Zhang

Nature· July 2021

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Genetics of extreme human longevity to guide drug discovery for healthy ageing.
Zhengdong D Zhang, Sofiya Milman, Jhih-Rong Lin, Shayne Wierbowski, Haiyuan Yu

Nat Metab· August 2020

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Beaver and Naked Mole Rat Genomes Reveal Common Paths to Longevity.
Xuming Zhou, Qianhui Dou, Guangyi Fan, Quanwei Zhang, Maxwell Sanderford, Zhengdong D Zhang

Cell Rep· July 2020

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PGA: post-GWAS analysis for disease gene identification.
Jhih-Rong Lin, Daniel Jaroslawicz, Ying Cai, Quanwei Zhang, Zhen Wang, Zhengdong D Zhang

Bioinformatics· May 2018

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Epigenetic alterations to Polycomb targets precede malignant transition in a mouse model of breast cancer.
Ying Cai, Jhih-Rong Lin, Quanwei Zhang, Kelly O'Brien, Cristina Montagna, Zhengdong D Zhang

Sci Rep· April 2018

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HEDD: Human Enhancer Disease Database.
Zhen Wang, Quanwei Zhang, Wen Zhang, Jhih-Rong Lin, Ying Cai, Zhengdong D Zhang

Nucleic Acids Res· January 2018

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Integrated rare variant-based risk gene prioritization in disease case-control sequencing studies.
Jhih-Rong Lin, Quanwei Zhang, Ying Cai, Bernice E Morrow, Zhengdong D Zhang

PLoS Genet· December 2017

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