Publications by authors named "Zhenning He"

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IDO1-mediated AhR activation up-regulates pentose phosphate pathway via NRF2 to inhibit ferroptosis in lung cancer.
Jiani Zhan, Yijia Chen, Yuying Liu, Yunqiu Chen, Zhiyao Li, Zhenning He

Biochem Pharmacol· June 2025

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Integrated vector genomes may contribute to long-term expression in primate liver after AAV administration.
Jenny A Greig, Kelly M Martins, Camilo Breton, R Jason Lamontagne, Yanqing Zhu, Zhenning He, Jessica A Chichester, Qi Zheng, Zhe Zhang

Nat Biotechnol· August 2024

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Prednisolone reduces the interferon response to AAV in cynomolgus macaques and may increase liver gene expression.
Lili Wang, Claude C Warzecha, Alexander Kistner, Jessica A Chichester, Peter Bell, Zhenning He

Mol Ther Methods Clin Dev· March 2022

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Developing a second-generation clinical candidate AAV vector for gene therapy of familial hypercholesterolemia.
Lili Wang, Ilayaraja Muthuramu, Suryanarayan Somanathan, Hong Zhang, Peter Bell, Zhenning He

Mol Ther Methods Clin Dev· September 2021

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Long-term stable reduction of low-density lipoprotein in nonhuman primates following in vivo genome editing of PCSK9.
Lili Wang, Camilo Breton, Claude C Warzecha, Peter Bell, Hanying Yan, Zhenning He

Mol Ther· June 2021

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A mutation-independent CRISPR-Cas9-mediated gene targeting approach to treat a murine model of ornithine transcarbamylase deficiency.
Lili Wang, Yang Yang, Camilo Breton, Peter Bell, Mingyao Li, Yan Che, Zhenning He, Chenyu Xu

Sci Adv· February 2020

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CRISPR/Cas9-mediated in vivo gene targeting corrects hemostasis in newborn and adult factor IX-knockout mice.
Lili Wang, Yang Yang, Camilo Ayala Breton, John White, Jia Zhang, Yan Che, Zhenning He

Blood· June 2019

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Meganuclease targeting of PCSK9 in macaque liver leads to stable reduction in serum cholesterol.
Lili Wang, Jeff Smith, Camilo Breton, Peter Clark, Jia Zhang, Yan Che, Zhenning He

Nat Biotechnol· September 2018

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AAV gene therapy corrects OTC deficiency and prevents liver fibrosis in aged OTC-knock out heterozygous mice.
Lili Wang, Peter Bell, Hiroki Morizono, Zhenning He, Elena Pumbo

Mol Genet Metab· April 2017

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Effects of Self-Complementarity, Codon Optimization, Transgene, and Dose on Liver Transduction with AAV8.
Peter Bell, Lili Wang, Shu-Jen Chen, Hongwei Yu, Yanqing Zhu, Zhenning He

Hum Gene Ther Methods· December 2016

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A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice.
Yang Yang, Lili Wang, Peter Bell, Deirdre McMenamin, Zhenning He, Chenyu Xu

Nat Biotechnol· March 2016

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Comparative Study of Liver Gene Transfer With AAV Vectors Based on Natural and Engineered AAV Capsids.
Lili Wang, Peter Bell, Suryanarayan Somanathan, Qiang Wang, Zhenning He

Mol Ther· December 2015

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Structural determinants of human ζ-globin mRNA stability.
Zhenning He, Decheng Song, Sebastiaan van Zalen, J Eric Russell

J Hematol Oncol· April 2014

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Structure of fully liganded Hb ζ2β2s trapped in a tense conformation.
Martin K Safo, Tzu-Ping Ko, Osheiza Abdulmalik, Zhenning He, Andrew H-J Wang

Acta Crystallogr D Biol Crystallogr· October 2013

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Dynamic posttranscriptional regulation of epsilon-globin gene expression in vivo.
Zhenning He, J Eric Russell

Blood· January 2007

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Effect of zeta-globin substitution on the O2-transport properties of Hb S in vitro and in vivo.
Zhenning He, J Eric Russell

Biochem Biophys Res Commun· December 2004

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Antisickling effects of an endogenous human alpha-like globin.
Zhenning He, J Eric Russell

Nat Med· April 2004

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A human embryonic hemoglobin inhibits Hb S polymerization in vitro and restores a normal phenotype to mouse models of sickle cell disease.
Zhenning He, J Eric Russell

Proc Natl Acad Sci U S A· August 2002

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A high-throughput microplate method for assessing aggregation of deoxygenated hemoglobin s heterotetramers in vitro.
Zhenning He, J Eric Russell

Anal Biochem· July 2002

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