Overall, the discussions reflect a balanced curiosity about how subjective perceptions can be misleading, with examples such as mentions of the study where patients felt better with fake treatments while objective measures showed no real improvement; language such as 'discrepancy' and 'demonstration' underscores analytical tone and cautious interpretation of the results, indicating a moderate level of interest and engagement.
AgreementModerate agreement
Many discussions highlight the discrepancy between subjective feelings of improvement and objective measures, indicating general agreement with the study's findings.
InterestModerate interest
Participants exhibit moderate interest, often referencing the study and its implications without intense emotional language.
EngagementModerate engagement
Many posts analyze the methodology and raise questions about the placebo effect, showing a thoughtful level of engagement.
ImpactModerate impact
There is recognition that these findings challenge assumptions about subjective symptom relief, suggesting a modest but meaningful impact on clinical understanding.
Abstract in brief
In a study with asthma patients, albuterol significantly improved lung function (FEV1) by about 20%, whereas placebo and sham treatments showed only a 7% increase.
Despite the physiological benefits of albuterol, patients' subjective feelings of improvement were similar across active, placebo, and sham treatments, and all these were perceived as better than no intervention.
The findings highlight that placebo effects can influence patients' perceived benefits in asthma, which complicates assessing treatment efficacy based solely on self-reported outcomes.
4/ Sier ikke om rapportert effekt skyldes behandling, naturlig bedring utover 10 uker eller placebo. Design tilsvarer det NICE konkluderer til lav/veldig lav vitenskapelig kvalitet. Samme oppsett ville konkludert at astma kan behandles med narremedisin https://t.co/0vDcFYENsz
Thank you for reading!
Sources:
1. https://t.co/If2H0OLNnO
2. https://t.co/SUJoqNwoe8
3. https://t.co/HJPe504QBp
4. https://t.co/4vVeTcj0dB
5. https://t.co/w9g29r4Vhr
Jun 3, 2025 · 19 likes · 1 share · 30,944 followersView post →
CA
Citron Archialcalin
@CitronAlcalin · X
C'est quelque chose qu'on a observé notamment dans cette étude où l'on a comparé le ressenti des patients et une mesure plus objective de l'évolution des symptômes.
https://t.co/ruRWOhDhfG
Oct 26, 2020 · 15 likes · 3,154 followersView post →
AP
Ana Carolina Peçanha
@AnaCarolPecanha · X
3/n O uso de um desfecho mole (tempo auto-referido para remissão dos sintomas) em um estudo aberto é bastante problemático, sobretudo porque já é descrito o potencial do efeito placebo relativo a terapia inalatória.
https://t.co/lUUEWq7Iw2
@Nina_Steinkopf Forskningssjef i FHI Signe Flottorp mener med sin logikk også at falsk akupunktur og placebo er effektivt behandling av astma, ettersom subjektive spørreskjema ville konkludert med nettopp det;
https://t.co/4HvuyerSDG
Mar 17, 2022 · 11 likes · 1 share · 252 followersView post →
PM
Pablo Malo
@pitiklinov · X
Artículo de Coyne:
https://t.co/h1rXbO8V4Q
paper original:
https://t.co/PKZhDaxkIk
Nov 3, 2020 · 9 likes · 2 shares · 75,765 followersView post →
In a study with asthma patients, albuterol significantly improved lung function (FEV1) by about 20%, whereas placebo and sham treatments showed only a 7% increase. The findings highlight that placebo effects can…
Did you know that up to 97 of reported pharmaceutical side effects might not be caused by the drug itself but by the power of negative expectations? This episode explores how our beliefs influence health and the…
Dec 12, 2025 · 6 likes · 2 shares · 897 followersView post →
CM
Caspian Kuma Folmsbee MD
@FolmsbeeMD · X
Albuterol for asthma over the last 10 years--is that considered a slow motion medical reversal? @adamcifu
https://t.co/Y1blCZIFIb
https://t.co/fGoJFhNFLg
@rieser_mathsci @trentgarrison @organichemusic @david_colquhoun Also, there was this really interesting study which had an objective endpoint (unlike, say, subjective pain scales, which is what most acupuncture studies use). https://t.co/mNncAQA2Go
Dec 13, 2022 · 1 like · 1,517 followersView post →
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Citron Archialcalin
@CitronAlcalin · X
@Sonic_urticant @MathieuMolimard @Clara_Locher Une manière de voir la différence c'est avec cet exemple sur l'asthme. Sur le paramètre subjectif influencé notamment par les effets placebos il n'y a pas forcément de supériorité du médicament.
Il y a en revanche un effet objectif.
https://t.co/ruRWOhUS7e
Jul 31, 2022 · 1 like · 3,154 followersView post →
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Allen 13
@YanConstantin · X
RT @CitronAlcalin: Dans d'autres cas comme pour l'asthme, on peut avoir l'impression d'aller mieux sans que les symptômes ne s'améliorent r…
4/ Sier ikke om rapportert effekt skyldes behandling, naturlig bedring utover 10 uker eller placebo. Design tilsvarer det NICE konkluderer til lav/veldig lav vitenskapelig kvalitet. Samme oppsett ville konkludert at astma kan behandles med narremedisin https://t.co/0vDcFYENsz
@dhu_de Als spezifische Arzneimitteltherapie funktioniert Homöopathie schlicht gar nicht. Ihr Placeboeffekt kann höchstens in gefährlicher Weise via "subjektivem Empfinden" über den tats. physiolog. Zustand hinwegtäuschen.
https://t.co/Dcz1I2434P
May 19, 2022 · 4 likes · 6,499 followersView post →
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Krebiozen
@krebiozen · X
@Kirk_Laughead @Pivoting51 @JenniferSey Here's a study that shows this nicely:
https://t.co/gdGdCu2Er3
Asthma patients given a fake inhaler reported that their breathing improved (subjective improvement), but objective tests showed it had not.
@Nina_Steinkopf Forskningssjef i FHI Signe Flottorp mener med sin logikk også at falsk akupunktur og placebo er effektivt behandling av astma, ettersom subjektive spørreskjema ville konkludert med nettopp det;
https://t.co/4HvuyerSDG
Mar 17, 2022 · 11 likes · 1 share · 252 followersView post →
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تئوفیلینوس
@GloktaSand · X
@niki_taa_a در ضمن خوب شدن علامتی مثل درد لزوما به معنای هیستریک بودن مریض نیست.
"Active Albuterol or Placebo, Sham Acupuncture, or No Intervention in Asthma | NEJM" https://t.co/EC2FOwXahr
@NMacFa @julierehmeyer @annamorrissart @exceedhergrasp1 @PhilM64 @domsalisbury @rcpsych @timkendall1 @TomKindlon @sjmnotes @jenbrea @b_m_hughes @brianvastag @davidtuller1 @adambeyoncelowe @doctorasadkhan Active Albuterol or Placebo, Sham Acupuncture, or No Intervention in Asthma:
The first three showed about the same improvement in their self-reports. Upon testing however, only the Active Albuterol patients showed objective improvement.
https://t.co/XnzuAyiNez
@AllenFrancesMD Below is a study discussed in the thread. Doubt can cause pulmonary patients to report that a medication isn't working when, in fact, it allows them to move much more air. The med doesn't work by placebo effect, but doubt can induce reports of inefficacy.
https://t.co/31Sz1sAuFb
Nov 10, 2021 · 2 likes · 1 share · 2,790 followersView post →
JS
John S
@JohnS888A · X
@PeterDKramer Not sure why people think changes subjective rating scale scores correspond to illness improvement.
See this study on asthmatics:
https://t.co/gZ6anxEy3R https://t.co/rwUrAC2u7j
3/n O uso de um desfecho mole (tempo auto-referido para remissão dos sintomas) em um estudo aberto é bastante problemático, sobretudo porque já é descrito o potencial do efeito placebo relativo a terapia inalatória.
https://t.co/lUUEWq7Iw2
Aug 10, 2021 · 3 likes · 15,128 followersView post →
CA
Citron Archialcalin
@CitronAlcalin · X
@schrod_erwin @BlaiseScalpa 1. Non. Il donne l'impression de les calmer mais ne les calme pas objectivement.
2. Il ne les remplace pas.
Pour la dernière fois : lisez la littérature sur le sujet.
https://t.co/ruRWOhDhfG
@DrL0cura @vbaosv @elnocturno @RuquiEs @jmmulet @roipipe @foterova @irradia_crea @vaiconDios @vix_pop @vixsalud @ElenaC_S @Infosectas @CSanzAndrea @escepticos @ej_molina_c @cescept @100cia_ @ricardocomsalud @JulioBasulto_DN @FerFrias Quizás con un ejemplo se vea más claro, por ejemplo, este estudio que compara la acupuntura, falsa acupuntura, albuterol o ningún tratamiento para tratar el asma:
https://t.co/NS7lUwG9CP
Sigue
Jan 17, 2021 · 4 likes · 13,559 followersView post →
EM
Eric Wan, MPH MBA
@ericlwan · X
Now, I've never NOT thought about carrying my inhaler, but here's why I bring placebo up. https://t.co/aAOhzlmqLy
C'est quelque chose qu'on a observé notamment dans cette étude où l'on a comparé le ressenti des patients et une mesure plus objective de l'évolution des symptômes.
https://t.co/ruRWOhDhfG
Oct 26, 2020 · 15 likes · 3,154 followersView post →
K
Krebiozen
@krebiozen · X
@VileThePro @SeanMac777333 @mcfunny @100Dianne @jkellyca @angela_bower @StopVaxxedLies @bamajc7 @ianfmusgrave @ilzheven @Death_is_final @RCPrentice @Monstercoyliar @Sambacon25 @peterre76976220 @KatLaRue7 @Shared_facts @RisetteMD @chaoticsx2 @SVaxhole @BoastIra @HupperichWerner @PaulVCooper1 @BeckyJohnson222 @HPVSideEffects @KayVonPaul @rainmc @barryjohnreid21 @MacBaird13 @ChrisJohnsonMD @Gardeniagal4 @SMcwoof @CiteretV @FrankDElia7 @MaggieC_95 @organicdot @HaircutSpock @ThatBackwoodsB @LG28640297 @JaneEOpie @doritmi @carlsmythe @MonstaTofu @Kathmarval @Jojofool1 @PJMoore1958 @MikePeterson_TH @_mamadeb @GeoffSchuler @HatgiNeal Altmed is great at fooling you into thinking you are better when objectively you are not. Which is potentially very dangerous.
https://t.co/gdGdCukfiB https://t.co/yBXSjjcU0B
@Mariaj0se79 @danzando_mp @lovenursingmery @c_jodar @MiguelDlaCamara @drmiguelmarcos @carloscomsalud tanto si se aplicaba el placebo, como una pseudoterapia como un medicamento real. Y los pacientes realmente se sentían mejor pero cuando se hicieron medidas objetivas se dieron cuenta que solo los que habían tomado el medicamento habían realmente mejorado.
https://t.co/8quU9GtTvs
RT @CoyneoftheRealm: Here is a classic demonstration of discrepancies obtained with objective vs subjective outcomes for placebo vs active…
Jan 28, 2020 · 1 share · 4,912 followersView post →
JC
James C.Coyne
@CoyneoftheRealm · X
Here is a classic demonstration of discrepancies obtained with objective vs subjective outcomes for placebo vs active treatment in asthma https://t.co/uYegLW5sMh https://t.co/oz6Pxrlp8Z
Jan 28, 2020 · 2 likes · 1 share · 9,528 followersView post →
MJ
Matthew Jacob
@mattindctweets · X
How susceptible are patients to the "placebo effect"? Studies like this suggest they are very susceptible: https://t.co/YXy56JMiIR #ScienceIsCool when it reveals insights like this. (Courtesy of @CrackedScience.) https://t.co/InSuLqlwGD
@Awithonelison @jkellyca @_mamadeb @TakeThatCDC @AlumiLynn @AndrewLazarus4 @JaneEOpie @kfunk937 @TioChango_ @BlueLionBlog @ChrisJohnsonMD @immunotoxPhD @BGLTHMND @_CWN @nicriopeele @fiski70 @mcfunny @MAhealthforkids @Sheldon_Walker_ @WendyOrent @ObamaNoMessiah @DanaElizabeth69 @BeckyJohnson222 @NeedyEedy @ianfmusgrave @badzoot7 @doritmi @Charbrevolution @LiveVaxFree @davidwells223 @2013Boodicca @felixbloodaxe @JohnSibson @QuatloosX @jp_miner @TThoughtmonger @LithiumMano @PedsID4Life @Monstercoyliar @Boxmenot @Rosewind2007 @saluce65 @StopVaxxedLies @kuriousmind93 @downeyballs @asiamoonbloom @VeritasEver @thereal_truther @rugbyrhino16 @ghoppe This study where they used fake asthma inhalers and sham acupuncture, and patients reported relief, but actual measurements of lung function found no effects compared to no treatment, makes me concerned that placebos could be actively dangerous.
https
@bmj_latest @jonathanasterne Would the risk of bias tool consider this clinical trial as having low risk of bias, assuming the trial did not include objective measurement of lung function (that reveals the total unreliability of self-rated improvement)? doi: 10.1056/NEJMoa1103319 https://t.co/PVabmSEWRJ
@DocPepperFR @Thomas_EELV @LehmannDrC @franceinfoplus @franceinfo C'est en effet ce qu'il se passe au mieux, au pire c'est uniquement du ressenti, les effets contextuels ne fonctionnent pas réellement sur l'asthme.
https://t.co/LE1cznwdTm
@wilcallef @a_berut @Matricule01 D'autant plus que l'effet placebo sur l'asthme est très limité et fonctionne en fait plutôt sur le ressenti des patients.
https://t.co/LE1cznwdTm
RT @CoyneoftheRealm: Nice demonstration of lack of correpondence of subjective support with validated objective measures of functioning in…
Jan 15, 2019 · 1 share · 8,237 followersView post →
PR
Pablo Richly
@PabloRichly · X
Buen día para recordar que a la hora de evaluar eficacia en salud sentirse mejor (subjetivo) no es igual a estar mejor (objetivo). https://t.co/tjh50v8410 https://t.co/39CJqARBHD
Jan 15, 2019 · 1 like · 6,713 followersView post →
JC
James C.Coyne
@CoyneoftheRealm · X
Nice demonstration of lack of correpondence of subjective support with validated objective measures of functioning in presence of placebo effects https://t.co/QEm6MTorm1 https://t.co/pd2Dr1C5Qq
Jan 15, 2019 · 3 likes · 1 share · 9,528 followersView post →
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