Why does MPS end 2-3 hrs after a meal? It's not lack of AAs or decrease in initiation factors (mTOR, eIF4, rpS6). Our best guess is energy https://t.co/LbwR07tWtb Our paper suggests depletion of energy (ATP) inhibits elongation (eEF2) which is the expensive phase of MPS. https://t.co/1UlPOx5IjD
Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats.
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Oct 2020 – Dec 2023Where it's discussed
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Facebook9 posts
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What people are saying
Posts reflect strong engagement with the article's core ideas, such as the role of energy depletion in muscle synthesis and how leucine or carbohydrates can maintain it, showing keen interest in translating animal research to human applications. The tone balances scientific reference with implications for enhancing muscle growth, utilizing words like 'maintains' and 'extends' to underline the significance of the findings.
Most discussions support the article's findings, emphasizing energy depletion as a key factor in muscle protein synthesis decline.
The posts show high interest, with mentions of specific mechanisms like energy levels and translation elongation, indicating engagement with the scientific details.
Participants reference the study's implications for both animal and human research, engaging with the methodology and potential applications.
The discussions recognize the potential impact of these findings on dietary supplement strategies and muscle health, though some note the need for further human studies.
Abstract in brief
- The study found that after a meal, muscle protein synthesis (MPS) peaks at around 90 minutes and then goes back to normal by 180 minutes, even though some signaling pathways like mTORC1 stay active.
- Giving rats leucine (Leu) or carbohydrates (CHO) two hours after the meal helps keep MPS elevated longer, up to 180 minutes, by improving cellular energy levels.
- The results suggest that the decline in MPS despite active mTORC1 signaling is due to a block in translation elongation caused by reduced energy in the muscle cells, which can be mitigated by Leu or CHO supplements.]
Top posts
Most liked on X and Bluesky@TheBhupiThakur @ImJosefRakich @JeffNippard @BioLayne @MennoHenselmans @team3dmj @misraetel @EricTrexler Human research needed, but in animal models, administering leucine or carbs ∼2 h after a meal maintains cellular energy status and extends MPS duration. https://t.co/lI9yTDF24c
RT @donlayman: Why does MPS end 2-3 hrs after a meal? It's not lack of AAs or decrease in initiation factors (mTOR, eIF4, rpS6). Our best g…
RT @donlayman: Why does MPS end 2-3 hrs after a meal? It's not lack of AAs or decrease in initiation factors (mTOR, eIF4, rpS6). Our best g…
All mentions
Enhancing Muscle Protein Synthesis with Leucine and Carbohydrates after Meals
The study shows that muscle protein synthesis peaks around 90 minutes after a meal and decreases by 180 minutes, even with active mTORC1 signaling. Supplementing with leucine or carbohydrates two hours post-meal…
BCAAs and Muscle Protein Synthesis: Key Facts and Benefits
Branched Chain Amino Acids are essential for muscle growth. This video explores their impact on muscle protein synthesis, emphasizing how leucine supplementation can extend post-meal muscle building and improve body…
RT @donlayman: Why does MPS end 2-3 hrs after a meal? It's not lack of AAs or decrease in initiation factors (mTOR, eIF4, rpS6). Our best g…
RT @donlayman: Why does MPS end 2-3 hrs after a meal? It's not lack of AAs or decrease in initiation factors (mTOR, eIF4, rpS6). Our best g…
RT @donlayman: Why does MPS end 2-3 hrs after a meal? It's not lack of AAs or decrease in initiation factors (mTOR, eIF4, rpS6). Our best g…
Why does MPS end 2-3 hrs after a meal? It's not lack of AAs or decrease in initiation factors (mTOR, eIF4, rpS6). Our best guess is energy https://t.co/LbwR07tWtb Our paper suggests depletion of energy (ATP) inhibits elongation (eEF2) which is the expensive phase of MPS. https://t.co/1UlPOx5IjD
@TheBhupiThakur @ImJosefRakich @JeffNippard @BioLayne @MennoHenselmans @team3dmj @misraetel @EricTrexler Human research needed, but in animal models, administering leucine or carbs ∼2 h after a meal maintains cellular energy status and extends MPS duration. https://t.co/lI9yTDF24c
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