Am J Physiol Endocrinol Metab December 2011 PMID 21917636

Leucine or carbohydrate supplementation reduces AMPK and eEF2 phosphorylation and extends postprandial muscle protein synthesis in rats.

Gabriel J Wilson, Donald K Layman, Christopher J Moulton, Layne E Norton, Tracy G Anthony, Christopher G Proud, S Indu Rupassara, Peter J Garlick

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Mentions

18
Peak: 4 in Dec 2023
across 4 sources since Oct 2020

Extended reach

17,625
potential audience

Total likes

129

Video views

954

Mentions per month

Oct 2020 – Dec 2023

Where it's discussed

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AI synopsis

What people are saying

Posts reflect strong engagement with the article's core ideas, such as the role of energy depletion in muscle synthesis and how leucine or carbohydrates can maintain it, showing keen interest in translating animal research to human applications. The tone balances scientific reference with implications for enhancing muscle growth, utilizing words like 'maintains' and 'extends' to underline the significance of the findings.

AgreementModerate agreement

Most discussions support the article's findings, emphasizing energy depletion as a key factor in muscle protein synthesis decline.

InterestHigh interest

The posts show high interest, with mentions of specific mechanisms like energy levels and translation elongation, indicating engagement with the scientific details.

EngagementModerate engagement

Participants reference the study's implications for both animal and human research, engaging with the methodology and potential applications.

ImpactModerate impact

The discussions recognize the potential impact of these findings on dietary supplement strategies and muscle health, though some note the need for further human studies.

Abstract in brief

  • The study found that after a meal, muscle protein synthesis (MPS) peaks at around 90 minutes and then goes back to normal by 180 minutes, even though some signaling pathways like mTORC1 stay active.
  • Giving rats leucine (Leu) or carbohydrates (CHO) two hours after the meal helps keep MPS elevated longer, up to 180 minutes, by improving cellular energy levels.
  • The results suggest that the decline in MPS despite active mTORC1 signaling is due to a block in translation elongation caused by reduced energy in the muscle cells, which can be mitigated by Leu or CHO supplements.]

Top posts

Most liked on X and Bluesky
Don Layman
@donlayman · X

Why does MPS end 2-3 hrs after a meal? It's not lack of AAs or decrease in initiation factors (mTOR, eIF4, rpS6). Our best guess is energy https://t.co/LbwR07tWtb Our paper suggests depletion of energy (ATP) inhibits elongation (eEF2) which is the expensive phase of MPS. https://t.co/1UlPOx5IjD

Dec 10, 2023 · 31 likes · 7 shares · 13,648 followers View post →
Shaun Ward
@MyNutritionSci · X

@TheBhupiThakur @ImJosefRakich @JeffNippard @BioLayne @MennoHenselmans @team3dmj @misraetel @EricTrexler Human research needed, but in animal models, administering leucine or carbs ∼2 h after a meal maintains cellular energy status and extends MPS duration. https://t.co/lI9yTDF24c

Apr 6, 2021 · 3 likes · 2,384 followers View post →
keto3000
@keto3000 · X

RT @donlayman: Why does MPS end 2-3 hrs after a meal? It's not lack of AAs or decrease in initiation factors (mTOR, eIF4, rpS6). Our best g…

Dec 10, 2023 · 7 shares · 436 followers View post →
Terrell Performance
@thegrayout · X

RT @donlayman: Why does MPS end 2-3 hrs after a meal? It's not lack of AAs or decrease in initiation factors (mTOR, eIF4, rpS6). Our best g…

Dec 10, 2023 · 7 shares · 123 followers View post →

All mentions

Terrell Performance
@thegrayout · X

RT @donlayman: Why does MPS end 2-3 hrs after a meal? It's not lack of AAs or decrease in initiation factors (mTOR, eIF4, rpS6). Our best g…

Dec 10, 2023 · 7 shares · 123 followers View post →
keto3000
@keto3000 · X

RT @donlayman: Why does MPS end 2-3 hrs after a meal? It's not lack of AAs or decrease in initiation factors (mTOR, eIF4, rpS6). Our best g…

Dec 10, 2023 · 7 shares · 436 followers View post →
brian liu
@brian3114611581 · X

RT @donlayman: Why does MPS end 2-3 hrs after a meal? It's not lack of AAs or decrease in initiation factors (mTOR, eIF4, rpS6). Our best g…

Dec 10, 2023 · 7 shares · 24 followers View post →
Don Layman
@donlayman · X

Why does MPS end 2-3 hrs after a meal? It's not lack of AAs or decrease in initiation factors (mTOR, eIF4, rpS6). Our best guess is energy https://t.co/LbwR07tWtb Our paper suggests depletion of energy (ATP) inhibits elongation (eEF2) which is the expensive phase of MPS. https://t.co/1UlPOx5IjD

Dec 10, 2023 · 31 likes · 7 shares · 13,648 followers View post →
Shaun Ward
@MyNutritionSci · X

@TheBhupiThakur @ImJosefRakich @JeffNippard @BioLayne @MennoHenselmans @team3dmj @misraetel @EricTrexler Human research needed, but in animal models, administering leucine or carbs ∼2 h after a meal maintains cellular energy status and extends MPS duration. https://t.co/lI9yTDF24c

Apr 6, 2021 · 3 likes · 2,384 followers View post →