PubHawk
August 2014 PMID 25068498

Cubanes in medicinal chemistry: synthesis of functionalized building blocks.

Joanna Wlochal, Robert D M Davies, Jonathan Burton

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Mentions

5
Peak: 2 in Jan 2021
across 3 sources since Feb 2016

Extended reach

208,066
potential audience

Total likes

5,181

Video views

191,076

Mentions per month

Feb 2016 – Apr 2023

Where it's discussed

  • X / Twitter2 posts
  • YouTube2 videos
  • Blogs1 articles

AI synopsis

What people are saying

The comments reflect a balanced view, with some highlighting the foundational chemistry work and its relevance for ongoing medicinal chemistry, exemplified by phrases like 'much more med chem exploration' and noting the article’s influence over the past seven years, demonstrating a sustained but cautious appreciation of its significance.

AgreementNeither agree nor disagree

The discussions show mixed opinions; some recognize the contribution but also note the ongoing exploration in the field.

InterestModerate interest

Participants display a moderate interest, especially in the availability of the research and its relevance to ongoing chemical research.

EngagementModerate engagement

Comments reference specific aspects, such as chemical synthesis and its application, indicating some depth of discussion.

ImpactModerate impact

The mention of continued research and references to the article indicate it has some influence within the community, though not universally regarded as game-changing.

Abstract in brief

  • This text discusses the development of new molecules that contain a chemical structure called cubane, which are useful for making medicines.
  • It explains that these cubane-based compounds are made from a starting material called cubane 14-dimethylester, which is commercially available.
  • The researchers have used various chemical methods to create these cubane building blocks, each with functional groups that make it easy to include them in medicinal chemistry research to develop new drugs.]
Read the full abstract

Top posts

Most liked on X and Bluesky
⌬Nessa Carson
@SuperScienceGrl · X

@PridefulMizuki @Zabbiemeister @HamiltonMorris @Explosions_Fire This is from a chemical, not pharmacological point of view, but first hit in my personal library is this https://t.co/mrYumCdbz6 - and refs therein. There's been much more med chem exploration since this was published 7 years ago; I see them in med chem papers from time to time

Jan 21, 2021 · 2 likes · 16,427 followers View post →
LibKey
@libkey_io · X

@SuperScienceGrl @PridefulMizuki @Zabbiemeister @HamiltonMorris @Explosions_Fire Access the paywalled article from your library: https://t.co/hBCJrNhS24 Promote scholarly access to content by simply adding https://t.co/SXSePSX5De in front of any DOI

Jan 21, 2021 · 554 followers View post →

All mentions

LibKey
@libkey_io · X

@SuperScienceGrl @PridefulMizuki @Zabbiemeister @HamiltonMorris @Explosions_Fire Access the paywalled article from your library: https://t.co/hBCJrNhS24 Promote scholarly access to content by simply adding https://t.co/SXSePSX5De in front of any DOI

Jan 21, 2021 · 554 followers View post →
⌬Nessa Carson
@SuperScienceGrl · X

@PridefulMizuki @Zabbiemeister @HamiltonMorris @Explosions_Fire This is from a chemical, not pharmacological point of view, but first hit in my personal library is this https://t.co/mrYumCdbz6 - and refs therein. There's been much more med chem exploration since this was published 7 years ago; I see them in med chem papers from time to time

Jan 21, 2021 · 2 likes · 16,427 followers View post →
サイコロを作ろう！ | Chem-Station (ケムステ)
Blogs

DOI: 10.1021/ol501750k. “Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere” Williams, C. M. et al. Angew. Chem. Int. Ed. 2016 ...

Feb 10, 2016 View →